Placental mesenchymal dysplasia

Lokan, Julie; Chan, Yuen; Agnesta, Franca

doi:10.1080/003130202760120571

Cited by 17 publications

(17 citation statements)

References 11 publications

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“…In the present case, ultrasound appeared to reveal a single pregnancy. Unlike partial moles, the majority of PMD are diploid [8]. In 70 - 80% of cases, the partial moles are triploid, often with 2 sets of paternal genes and 1 set of maternal genes as a result of dispermy fertilization [9].…”

Section: Discussionmentioning

confidence: 99%

“…However, in cases terminated before 20 weeks of gestation, the chorionic plate vessels are not dilated, and the normal and abnormal areas are not clearly delineated, suggesting that the vascular malformations develop progressively [12]. As the pregnancy advances, tangled congested vessels grossly resembling gray-white or dark-red wormlike structures may be identified within the parenchyma and are often most prominent in the subchorionic plate region near the fetal surface [8]. An ultrasound performed at 33 weeks' gestation seemingly detected this finding (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

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Placental mesenchymal dysplasia, a case of intrauterine sudden death of fetus with rupture of cirsoid periumbilical chorionic vessels

et al. 2011

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We report a 32-year-old woman (1-gravid, 1-para) with a vesicular lesion in her uterus that was pointed out on ultrasound at 8 weeks' gestation. Amniocentesis at 15 weeks' gestation showed a normal female karyotype, 46XX. As the pregnancy advanced, the mole-like lesion became relatively reduced. Throughout gestation, the maternal human chorionic gonadotropin level was normal, but the serum alpha fetoprotein level rose as her pregnancy progressed. Her fetus did not exhibit any remarkable anomalies. The patient visited our hospital complaining of a diminished feeling of fetal movements at 36 weeks 5 days' gestation, and intrauterine fetal death (IUFD) was confirmed. She delivered a 2336-g female without any definite anomalies. A pathological examination led to a diagnosis of placental mesenchymal dysplasia, and androgenetic/biparental mosaicism in the placenta was identified using p57kip2 immunohistochemical staining. And it also revealed that the rupture of the cirsoid chorionic vessels had led to IUFD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Placental mesenchymal dysplasia, a case of intrauterine sudden death of fetus with rupture of cirsoid periumbilical chorionic vessels

et al. 2011

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“…3 There has been only one probable PMD case with BWS features in a neonate with hematologic changes at birth. 13 In conclusion, fetuses who have PMD associated with the development of aberrant vasculature may present with hematologic complications. Prenatal recognition of PMD and its extent of vascularity might facilitate the prediction of fetal complications, such as BWS and hematologic disorder, as well as prevent the unnecessary termination of pregnancy due to misdiagnoses such as partial hydatidiform mole.…”

Section: Discussionmentioning

confidence: 98%

Placental Mesenchymal Dysplasia and Fetal Hematologic Disorder

Koga

Makimura²,

Tanaka³

et al. 2014

Journal of Pediatric Hematology/Oncology

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“…L'examen anatomopathologique placentaire viendra confirmer le diagnostic de dysplasie mésenchymateuse selon les critères définis par Lokan et al [16] avec macroscopiquement : placentomégalie supérieure au 95 e percentile, Fig. 12 Placenta macrovésiculaire à 28 semaines d'aménorrhée, cliché du docteur Boquet [2] vaisseaux chorioallantoïdiens tortueux, dilatés, anévrysmaux, vésicules parenchymateuses et microscopiquement : villosités hydropiques, modification chorioangiomatoïde, absence de prolifération trophoblastique et d'inclusion trophoblastique.…”

Section: Dysplasie Mésenchymateuse Placentaireunclassified