Placental mesenchymal dysplasia and hepatic cyst

Rosner-Tenerowicz, Anna; Pomorski, Michał; Fuchs, Tomasz; Śliwa, Jakub; Zimmer-Stelmach, Aleksandra; Bek, Wiktor; Zimmer, Mariusz

doi:10.5603/gp.a2020.0129

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…Two patients each had placenta previa and polyhydroamnios 8. In addition, six cases were associated with hepatic cysts, with five requiring postdelivery surgical resection and one resulting in stillbirth 9–14. Although PMD is generally considered benign, Sun et al reported a case of PMD in a 26-year-old woman who converted to choriocarcinoma postpregnancy.…”

Section: Discussionmentioning

confidence: 99%

Placental mesenchymal disease masquerading as molar pregnancy with a favourable maternal and fetal outcome

Sharma,

Gupta,

Rathore

et al. 2024

BMJ Case Rep

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Placental mesenchymal dysplasia (PMD) is an exceptionally rare placental anomaly characterised by placentomegaly and grape-like vesicles resembling partial mole on ultrasonography, yet it can coexist with a viable fetus. We present the case of a primigravida who presented at 22 weeks gestation with a suspected partial mole but with a normally growing fetus. The differential diagnoses considered included placental mesenchymal disease, partial mole and twin pregnancy with molar pregnancy. With normal beta HCG levels and prenatal invasive testing reports, a probable diagnosis of PMD was made, and after thorough counselling, the decision was made to continue the pregnancy. The pregnancy progressed until 37 weeks, culminating in the uneventful delivery of a 2.4 kg healthy male infant. Histopathology confirmed PMD. Early recognition and management of PMD pose significant challenges, given its rarity. Prenatal identification of PMD during both early and late gestation could avert unnecessary termination of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Placental mesenchymal disease masquerading as molar pregnancy with a favourable maternal and fetal outcome

Sharma,

Gupta,

Rathore

et al. 2024

BMJ Case Rep

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show abstract

“…The prognosis of pregnancy in PMD may be poor, however it may be associated with good pregnancy outcomes and lead to the birth of a healthy baby (16). In January 2021, Kodera et al published the largest study on PMD cases with their clinical data.…”

Section: Discussionmentioning

confidence: 99%

Placental Mesenchymal Dysplasia Associated with Severe Intrauterine Growth Restriction: A Case Report

et al. 2023

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Placental mesenchymal dysplasia (PMD) is an uncommon placental lesion, which may mimic molar pregnancy at gross and microscopic examination. PMD can be associated with fetal growth restriction, Beckwith-Wiedemann syndrome, intrauterine fetal death, and preterm delivery. Nonetheless, it may also be associated with a normal appearing fetus. We aimed to emphasize that clinicians, radiologists, and pathologists should be aware of PMD as one of the etiologies of intrauterine growth restriction (IUGR). We presented the case of a 27-year-old gravida 1, para 1 woman who was admitted to Ayatollah Rouhani hospital, in Babol, Iran, at 30 weeks of gestation due to severe IUGR and fetal tachycardia. Ultrasound examination showed uteroplacental insufficiency and increased resistive index (RI) of umbilical artery. At last, a normal female fetus (1320 g) with no definitive anomalies was delivered by cesarean section. Pathological examination revealed cystically dilated stem villi with peripherally located thick-walled muscular stem vessels, and also stromal fibroblasts overgrowth in some stem villi. None of the examined sections revealed trophoblastic proliferation or stromal trophoblastic inclusion. The findings confirmed the diagnosis of PMD. Careful radiological and pathological examination should be performed in the case of IUGR for ruling out the rare placental abnormalities, including PMD.

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“…Although the reported PMD incidence is around 0.02% of all pregnancies, with a female-to-male sex ratio of 3.6–4.0: 1 [ 3 , 4 , 5 ], the exact incidence is, unfortunately, unknown, as this rare clinical entity is often mistaken for molar pregnancy due to their similar ultrasound features [ 6 ]. Most of the PMD cases correlate with intrauterine fetal death (IUFD), intrauterine growth restriction (IUGR), Beckwith–Wiedemann syndrome (BWS), or preeclampsia, but in rare cases, it can associate a normal fetus pregnancy [ 3 , 7 , 8 ]. Fetal karyotyping is mandatory and is usually euploid, although patients with aneuploidy have been reported [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Fetal karyotyping is mandatory and is usually euploid, although patients with aneuploidy have been reported [ 1 ]. Pathologically, PMD is characterized by mesenchymal hyperplasia, aneurysmal dilatation of chorionic vessels, edema of the stem-cell villi, and the absence of trophoblastic proliferation [ 1 , 2 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report

et al. 2022

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We describe a 22-year-old woman (2-gravid) case who was referred to our clinic at 18 weeks of gestation for a placenta with vesicular lesions discovered on prenatal examination routine. An ultrasound exam at 31 weeks of gestation showed numerous vesicular lesions, which gradually augmented as the pregnancy advanced. A live normal-appearing fetus was confirmed by intrauterine growth restriction (IUGR). The maternal serum β-human chorionic gonadotropin level remained in normal ranges. At some point, a multidisciplinary medical consensus considered the termination of the pregnancy, but the patient refused to comply. At 33 weeks of gestation, preterm premature rupture of membranes (pPROM) occurred, and she spontaneously delivered a 1600 g healthy female baby with a good long-term outcome. Placental mesenchymal dysplasia (PMD) was retrospectively diagnosed after confronting the data from ultrasound, chorionic villus sampling (CVS), amniocentesis, pathological examination, and immunohistochemical stain. The lack of sufficient reports of PMD determines doctors to be cautious and reserved, approaching these cases more radically than necessary. We reviewed this disease and searched for all cases of PMD associated with healthy, live newborns.

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Placental mesenchymal dysplasia and hepatic cyst

Cited by 3 publications

References 3 publications

Placental mesenchymal disease masquerading as molar pregnancy with a favourable maternal and fetal outcome

Placental mesenchymal disease masquerading as molar pregnancy with a favourable maternal and fetal outcome

Placental Mesenchymal Dysplasia Associated with Severe Intrauterine Growth Restriction: A Case Report

A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report

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