Placental pathology in cancer during pregnancy and after cancer treatment exposure

Wolters, Vera; Lok, Car; Gordijn, Sanne J.; Wilthagen, Erica A.; Sebire, Neil J.; Khong, T. Y.; Voorn, J. Patrick van der; Amant, Frédéric

doi:10.1016/j.placenta.2021.06.003

Cited by 12 publications

(4 citation statements)

References 108 publications

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“…Although it has been suggested that irradiation can cause maternal vascular malperfusion (MVM), no signs of MVM were observed. Whether irradiation causes direct damage to the villous vasculature is yet unclear [21] . In vitro and animal studies need to be conducted to investigate the plausible pathophysiological mechanisms of fetal radiation on FVM.…”

Section: Discussionmentioning

confidence: 99%

Proton therapy of a pregnant patient with nasopharyngeal carcinoma

Heimovaara

Blommaert

Free

et al. 2022

Clinical and Translational Radiation Oncology

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Section: Discussionmentioning

confidence: 99%

Proton therapy of a pregnant patient with nasopharyngeal carcinoma

Heimovaara

Blommaert

Free

et al. 2022

Clinical and Translational Radiation Oncology

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“…At the same time, chemotherapeutic compounds have been shown to affect placental biology, perturbing trophoblast differentiation and placental angiogenesis [17][18][19]. In particular, placentas exposed to chemotherapy regimens containing cyclophosphamide and epirubicin exhibited elevated levels of apoptosis and increased oxidative damage [20]. The extent to which this placental toxicity contributes to potential adverse fetal outcomes is largely underexplored.…”

Section: Introductionmentioning

confidence: 99%

Additive genotoxic effects in cord blood cells upon indirect exposure to chemotherapeutic compounds crossing an in vitro placental barrier

Velazquez,

Loier,

Struys

et al. 2023

Preprint

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Prenatal exposure to toxins can adversely affect long-term health outcomes of the offspring. Though chemotherapeutics are now standard of care for treating cancer patients during pregnancy, certain compounds are known to cross the placenta and harm placental tissue. The consequences for the fetus are largely unexplored.Here we examined the responses of newborn cord blood mononuclear cells in tissue culture to two chemotherapeutic drugs, cyclophosphamide and epirubicin, when either directly exposed to these drugs, or indirectly after crossing a placenta trophoblast bilayer barrier. Cord blood mononuclear cells exposed to the conditioned media obtained from cyclophosphamide-exposed trophoblast barriers showed a significant 2.4-fold increase of nuclear ROS levels compared to direct exposure to cyclophosphamide. Indirect exposure to epirubicine-exposed trophoblast barriers not only enhanced nuclear ROS levels but also significantly increased the fraction of cord blood cells with double strand breaks, relative to directly exposed cells. Neither apoptosis nor proliferation markers were affected in cord mononuclear blood cells upon direct or indirect exposure to cyclophosphamide or epirubicin.Our data suggests that trophoblast cells exposed to cyclophosphamide or epirubicine may induce an indirect ‘bystander’ effect and can aggravate genotoxicity in the fetal compartment.

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“…Oxaliplatin, in a particulate, is frequently applied for many malignancies that commonly occur during pregnancy [6] . Correspondingly, utero exposure has been correlated with pathologically growth restriction for offspring during chemotherapy [7] . Hepatotoxicity correlated with chemotherapy administration distinguished by elevation in liver enzymes, venoocclusive disease, steatohepatitis, and also with possible hepatic fibrosis and chronic liver failure [8] .…”

Section: Introductionmentioning

confidence: 99%

Histological Studies on Livers of Rats’ Mothers and Their Offspring Following Oxaliplatin Treatment, and the Possible Protective Role of Propolis

Kamal,

Ahmed,

Zaghloul

et al. 2023

Egyptian Journal of Zoology

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Knowledge about the possibility of chemotherapy during pregnancy is increasing. Oxaliplatin, a third-generation of platinum drug, is the main agent for treatment of many cancers. It causes abnormal changes in the cells of the vital organs, especially those responsible for detoxification such as the liver. The present study focused on the evaluation of the possible alleviative role of propolis against the hepatotoxicity induced by oxaliplatin in the rats' mothers before and during the period of pregnancy, and their offspring. A total of 35 adult female albino Sprague-Dawley rats were randomly divided into seven groups (n=5). Group "1" (the control group) received distilled water during the experimental period. Group "2" received a daily oral dose of propolis 200 mg/kg body weight (bw), group "3" received an intravenous dose of 3 mg/kg bw of oxaliplatin three times per week, and group "4" received oxaliplatin with propolis in a combination for 21 days before pregnancy. Similarly, groups 5-7 received the same treatment and doses as groups 2-4, respectively, during the period of pregnancy. The results of the current study demonstrated that the oxaliplatin treatment before and after pregnancy induced degeneration and fibrosis in the maternal and fetal liver tissues. Nevertheless, the results demonstrated that the combined administration of oxaliplatin with propolis alleviated the hepatotoxicity associated with oxaliplatin treatment either before or during pregnancy, indicating the promising potential role of propolis as anti-toxic of natural origin.

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Placental pathology in cancer during pregnancy and after cancer treatment exposure

Cited by 12 publications

References 108 publications

Proton therapy of a pregnant patient with nasopharyngeal carcinoma

Proton therapy of a pregnant patient with nasopharyngeal carcinoma

Additive genotoxic effects in cord blood cells upon indirect exposure to chemotherapeutic compounds crossing an in vitro placental barrier

Histological Studies on Livers of Rats’ Mothers and Their Offspring Following Oxaliplatin Treatment, and the Possible Protective Role of Propolis

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