Placental pathology in live births conceived with in vitro fertilization after fresh and frozen embryo transfer

Sacha, Caitlin R.; Harris, Amy L.; James, Kaitlyn; Basnet, Kristen M; Freret, Thomas; Yeh, John; Kaimal, Anjali J; Souter, Irene; Roberts, Drucilla J.

doi:10.1016/j.ajog.2019.09.047

Cited by 66 publications

(54 citation statements)

References 53 publications

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“…Embryonic growth and pregnancy outcomes are dependent on trophoblast and placental functioning, where placental dysfunction is strongly associated with vascular related pregnancy complications, such as PTB and preeclampsia. Pregnancies resulting after frozenthawed ET are associated with more anatomic and vascular placental pathology (Kaser et al, 2015;Sacha et al, 2020). Furthermore, epigenetic differences in placentae are described, with different microRNA expression profiles in term placentae after frozen-thawed ET and fresh ET (Hiura et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Prenatal growth trajectories and birth outcomes after frozen–thawed extended culture embryo transfer and fresh embryo transfer: the Rotterdam Periconception Cohort

Duijn

Hoek

Rousian

et al. 2021

Reproductive BioMedicine Online

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Van Duijn & Hoek et al. 2020 3 Research question: Are there differences in prenatal growth trajectories and birth outcomes between singleton pregnancies conceived after in vitro fertilization (IVF) treatment with either frozen-thawed extended culture embryo transfer (ET) at day 5, fresh ET at day 3 or naturally conceived pregnancies? Design: From a prospective hospital-based cohort, a total of 859 singleton pregnancies were selected, including 133 conceived after IVF with frozen-thawed ET, 276 after fresh ET, and 450 naturally conceived pregnancies. Longitudinal three-dimensional (3D) ultrasound scans were performed at 7, 9 and 11 weeks of gestation for offline crown-rump length (CRL) and embryonic volume (EV) measurements. Second trimester estimated fetal weight was based on growth parameters obtained during the routine fetal anomaly scan at 20 weeks of gestation. Birth outcome data were collected from medical records.Results: No differences regarding embryonic growth trajectories were observed between frozenthawed ET and fresh ET. Birthweight percentiles after fresh ET were lower than after frozen-thawed ET (38.0 and 48.0 (p=0.046) respectively). The prevalence of non-iatrogenic preterm birth was significantly lower in pregnancies resulting from fresh ET as compared to frozen-thawed ET (4.7% and 10.9% (p=0.026) respectively). Compared to naturally conceived pregnancies, birthweight percentiles and percentage of non-iatrogenic PTB were significantly lower in pregnancies after fresh ET and gestational age at birth was significantly higher. Conclusion:Here we show that embryonic growth is comparable between singleton pregnancies conceived after fresh and frozen-thawed ET. The lower relative birthweight and PTB rate in pregnancies after fresh ET than after frozen-thawed ET and naturally conceived pregnancies warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Prenatal growth trajectories and birth outcomes after frozen–thawed extended culture embryo transfer and fresh embryo transfer: the Rotterdam Periconception Cohort

Duijn

Hoek

Rousian

et al. 2021

Reproductive BioMedicine Online

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“…Patients then underwent controlled ovarian hyperstimulation by luteal-phase gonadotropin-releasing hormone (GnRH) agonist, GnRH antagonist downregulation, or GnRH agonist flare protocol, with follicular synchronization and pituitary downregulation as clinically indicated and previously described [17,[19][20][21]. During treatment with recombinant gonadotropins (follitropin beta, Follistim, Merck, Kenilworth, NJ, or follitropin alpha, Gonal-F, EMD-Serono; and m e n o t r o p i n s , M e n o p u r o r R e p r o n e x , F e r r i n g Pharmaceuticals, Parsippany, NJ), patients were serially monitored with transvaginal ultrasound and serum estradiol (E 2 ) to assess follicular measurements and endometrial thickness.…”

Section: Ovarian Stimulation Protocolsmentioning

confidence: 99%

Follicular fluid anti-Müllerian hormone (AMH) concentrations and outcomes of in vitro fertilization cycles with fresh embryo transfer among women at a fertility center

Sacha

Chavarro

Williams

et al. 2020

J Assist Reprod Genet

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Purpose To enhance the understanding of the clinical significance of anti-Müllerian hormone (AMH) in follicular fluid, we aimed to determine the variability of AMH concentrations in follicular fluid within and across IVF cycles and whether high follicular fluid AMH concentrations are associated with improved clinical IVF outcomes. Methods This was a retrospective cohort study of companion follicular fluid and serum samples from 162 women enrolled in the Environment and Reproductive Health (EARTH) Study between 2010 and 2016. AMH concentrations were quantified using a sandwich enzyme-linked immunosorbent assay. Spearman correlation and intra-class correlation (ICC) were calculated to assess variability of follicular fluid AMH, and generalized linear mixed models were used to evaluate the associations of FF AMH with IVF outcomes. ResultsThe median (interquartile range, IQR) age of the 162 women was 34.0 years (32.0, 37.0). Follicular fluid AMH concentrations were highly correlated between follicles within each IVF cycle (Spearman r = 0.78 to 0.86) and across cycles for each woman (ICC 0.87 (95% CI 0.81 to 0.92)). Compared with women in the highest tertile of FF AMH (mean AMH = 2.3 ng/ml), women in the lowest tertile (mean AMH = 0.2 ng/ml) had lower serum AMH (T1 = 0.1 ng/ml vs. T3 = 0.6 ng/ml, p < 0.0001). In adjusted models, higher tertiles of follicular fluid AMH concentrations were associated with lower mean endometrial thickness and higher probability of clinical pregnancy. Conclusions Follicular fluid AMH concentrations show little variability between pre-ovulatory follicles, and higher preovulatory follicular fluid AMH may predict a higher probability of clinical pregnancy.

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“…It has long been clear that the maternal age has been associated with pathology of gestation such as diabetes, preeclampsia, infections, hormonal disorder, placental and myometrial vascular lesions, but also with burdened pathological situations during pregnancy ( 17 , 41 ). Our results show that women who had conceived with IVF procedures are of a higher mean age than the women who conceived naturally (p<0.001).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, complications during pregnancy are more common in women after IVF conception than women who conceived naturally ( 15 ). It is already known that placenta abnormalities ( 16 , 17 ), and especially placenta accreta, which has a catastrophic effect on obstetrics, are associated with IVF pregnancies ( 18 ). Placenta abnormalities are usually associated with massive postpartum hemorrhages and have become the major indicator for emergent peripartum hysterectomy ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

The Kind of Conception Affects the Kind of Cesarean Delivery in Primiparous Women

Antoniou¹,

Orovou²,

Iliadou³

et al. 2021

Mater Sociomed

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Background: So far, multiple factors have been found to be related to the IVF procedure, the most prevalent being extremes of maternal age, infections, previous gynecological history, infertility and others. Although women achieve the coveted pregnancy with the development of IVF technology, the rapid increase contributes to the increase of primary cesarean sections rates. Objective: The aim of the study was to identify if the kind of conception affects the kind of cesarean delivery among primiparous women in Greece. Methods: This cross-sectional observational study took place from September 2019 to February 2020 at the University Hospital of Larisa in Greece. One hundred and sixty-two primiparous women who underwent a cesarean section (c-section) after IVF (n=27) and natural conception (n=135) participated in the study. Results: The mean age of the IVF and natural conception groups were 36.22 and 31.08 years, respectively. Nineteen (70.4%) women of the IVF group had a previous medical or gynecological history in contrast to 48 (35.6%) women of the natural conception group. Only 55.6% of the IVF group had a full-term pregnancy unlike 88.1% of women in the natural conception group. An elective c-section was performed in 18 (66.7%) of the women who conceived after IVF, as opposed to 45 (33.3%) of the women who conceived naturally. Conclusion: This cross-sectional study showed that IVF conception was associated with high rates of elective cesarean section as opposed to women with natural conception. The causes of c-sections must be evidence based because the primary cesarean delivery is a major factor contributing to increased c-section rates.

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Placental pathology in live births conceived with in vitro fertilization after fresh and frozen embryo transfer

Cited by 66 publications

References 53 publications

Prenatal growth trajectories and birth outcomes after frozen–thawed extended culture embryo transfer and fresh embryo transfer: the Rotterdam Periconception Cohort

Prenatal growth trajectories and birth outcomes after frozen–thawed extended culture embryo transfer and fresh embryo transfer: the Rotterdam Periconception Cohort

Follicular fluid anti-Müllerian hormone (AMH) concentrations and outcomes of in vitro fertilization cycles with fresh embryo transfer among women at a fertility center

The Kind of Conception Affects the Kind of Cesarean Delivery in Primiparous Women

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