Placental size and the prediction of severe early‐onset intrauterine growth restriction in women with low pregnancy‐associated plasma protein‐A

Proctor, Leslie; Toal, Meghana; Keating, Sarah; Chitayat, David; Okun, Nan; Windrim, Rory; Smith, Gordon C. S.; Kingdom, John

doi:10.1002/uog.7308

Cited by 139 publications

(104 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[56][57][58] ultrasound assessment, using uterine artery doppler and placental morphology, is of value to distinguish a subset of pregnancies at high risk of early severe FGR. [59][60][61] In women with risk factors for intrauterine growth restriction, uterine artery doppler screening at 19 to 23 weeks may identify pregnancies at risk of antepartum stillbirth and preterm delivery due to intrauterine growth restriction and placental disease. 62 In pregnancies in which intrauterine growth restriction due to uteroplacental vascular insufficiency is diagnosed, maternal surveillance for the development of severe preeclampsia with adverse features is warranted.…”

Section: Screening and Diagnosismentioning

confidence: 99%

Fetal growth restriction: aetiology, screening, diagnosis and management

Augusthy

2015

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Foetal growth restriction (FGR) is a pathological condition that refers to a foetus that fails to reach his/her genetically predetermined growth potential. FGR remains a leading contributor to perinatal mortality and morbidity and metabolic syndrome in later life. The purpose of this review is to provide the summary statements of the aetiology of FGR and to establish a framework for screening, diagnosis, and management of pregnancies affected with foetal growth restriction. For this study, published literature was retrieved through searches of PubMed (Medline), Highwire, Google Scholar, Scopus, Cochrane Database of Systematic Reviews. Conference/Seminar proceedings, textbooks, previously published systematic reviews, controlled clinical trials, high quality prospective and retrospective observational studies, research articles and unpublished studies were also used for this study. The identification of FGR begins with assessment of maternal, foetal, placental and environmental risk factors and the diagnosis is made by Ultrasound biometry examination. Functional assessment of placental and foetal circulation by Doppler velocimetry and blood flow volume, together with computerized assessment of foetal heart rate variability, are key examinations in early and late FGR to assess severity of the disease and monitor foetal wellbeing. Appropriate timing of delivery in early FGR might change the outcome, and appropriate monitoring in late and term FGR might avoid unnecessary interventions.

show abstract

Section: Screening and Diagnosismentioning

confidence: 99%

Fetal growth restriction: aetiology, screening, diagnosis and management

Augusthy

2015

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…A combined Doppler and hormonal profile of placental function may be of value to screen for pregnancies that are at increased risk of pre-eclampsia, fetal death, and IUGR even as early as the first trimester 11,12 .…”

Section: Uterine Circulationmentioning

confidence: 99%

Colour Doppler in IUGR- Where are we and where do we go?

Lulla

Garg

2010

J Obstet Gynecol India

View full text Add to dashboard Cite

Intra-uterine growth restriction (IUGR) is an important perinatal problem giving rise to increased morbidity and mortality in the growth restricted fetus. The aim of fetal medicine today, is to prevent the mere occurrence of IUGR in high risk pregnancies and to deliver the fetuses already afflicted with growth restriction, before they have suffered from the effects of hypoxia. The use of Doppler provides this information, which is not readily obtained from the other conventional tests of fetal well being. The Doppler patterns follow a longitudinal trend in the arterial and venous circulation of the fetus as well as the placental vasculature guiding management decisions regarding the appropriate time of delivery. Progressive knowledge of the fetal circulation and its adaptation when the fetus is subjected to hypoxia, has helped us recognize the early signs of IUGR thereby improving the prognosis of these complicated pregnancies. It has therefore become the gold standard in the management of the growth-restricted fetus.

show abstract

“…In particular, low maternal serum pregnancy-associated plasma protein-A(PAPP-A), at 11-13 weeks of gestation, is associated with stillbirth, infant death, intrauterine growth restriction, preterm birth,, pre echlampsia in chromosomally normal features, while a raised nuchal translucency is associated with specific structural abnormalities and genetic syndromes. [1][2] A low PAPP-A is defined as maternal serum PAPP-A value < 0.4 MoM, with increased frequency of adverse obstetrical outcomes noted below this level.…”

Section: Introductionmentioning

confidence: 99%