Placental Syncytiotrophoblast-Derived Extracellular Vesicles Carry Active NEP (Neprilysin) and Are Increased in Preeclampsia

Gill, Manjot K.; Motta-Mejia, Carolina; Kandžija, Neva; Cooke, William R.; Zhang, Wei; Cerdeira, Ana Sofia; Bastie, Claire C.; Redman, Christopher W.G.; Vatish, Manu

doi:10.1161/hypertensionaha.119.12707

Cited by 101 publications

(80 citation statements)

References 27 publications

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“…Relevant for hypertension, EVs released by placental syncytiotrophoblasts carry neprilysin, an enzyme from the family of membrane-bound metalloproteases. Neprilysin cleaves vasopeptides, thus contributing to the establishment of hypertension, a hallmark of PE [80]. Interestingly, the rate of early onset of PE in high risk women could be significantly reduced by aspirin and this effect was mediated by down-regulation of miR-155 transported by EVs [81,82].…”

Section: Preeclampsiamentioning

confidence: 99%

Exosomes as Messengers between Mother and Fetus in Pregnancy

Czernek

Duechler

2020

IJMS

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The ability of exosomes to transport different molecular cargoes and their ability to influence various physiological factors is already well known. An exciting area of research explores the functions of exosomes in healthy and pathological pregnancies. Placenta-derived exosomes were identified in the maternal circulation during pregnancy and their contribution in the crosstalk between mother and fetus are now starting to become defined. In this review, we will try to summarize actual knowledge about this topic and to answer the question of how important exosomes are for a healthy pregnancy.

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Section: Preeclampsiamentioning

confidence: 99%

Exosomes as Messengers between Mother and Fetus in Pregnancy

Czernek

Duechler

2020

IJMS

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“…Neprilysin (NEP) is a membrane‐bound metalloprotease that could reduce the activation of peptides such as vasodilators, natriuretics and diuretics. A recent study suggests that active NEP is highly expressed in STBEVs of PE patients, which are likely to be associated with the pathogenesis of PE …”

Section: Evs In Complicated Pregnancymentioning

confidence: 99%

“…Neprilysin (NEP), a membrane‐bound metalloprotease, is highly expressed in STBEVs from the plasma of PE patients as detected by flow cytometry. Thus, the higher level of PLAP + NEP + EVs is suggested as a promising biomarker of PE . Son et al demonstrate that the expression level of podocyte‐specific protein nephrin is elevated in the urine of PE women and is correlated with proteinuria and diastolic blood pressure.…”

Section: Evs As Biomarkers For Pregnancy‐related Diseasesmentioning

confidence: 99%

Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

Zhang

Fan

et al. 2020

J Cellular Molecular Medi

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Extracellular vesicles (EVs) are nanosized, membranous vesicles released by almost all types of cells. Extracellular vesicles can be classified into distinct subtypes according to their sizes, origins and functions. Extracellular vesicles play important roles in intercellular communication through the transfer of a wide spectrum of bioactive molecules, contributing to the regulation of diverse physiological and pathological processes. Recently, it has been established that EVs mediate foetal-maternal communication across gestation. Abnormal changes in EVs have been reported to be critically involved in pregnancy-related diseases. Moreover, EVs have shown great potential to serve as biomarkers for the diagnosis of pregnancy-related diseases.In this review, we discussed about the roles of EVs in normal pregnancy and how changes in EVs led to complicated pregnancy with an emphasis on their values in predicting and monitoring of pregnancy-related diseases.

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“…Interestingly, miR-210, a hypoxia-induced miRNA, recruiting Hypoxia Inducible Factor 1 Subunit Alpha (HIF-1α) and participating to angiogenesis and cell migration processes, is carried by EVs derived from extravillous and villous trophoblasts. It has been demonstrated that miR-210 is one of the most highly expressed miRNAs in the placenta as well as in the maternal blood [52,59,60]. Syncytiotrophoblast-derived EVs, staining positive for PLAP, were analyzed for several tRNA species in normal pregnancies.…”

Section: Extracellular Vesicles As Biomarkersmentioning

confidence: 99%

Extracellular Vesicles in Feto–Maternal Crosstalk and Pregnancy Disorders

Buca

Bologna

D’Amico

et al. 2020

IJMS

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Extracellular vesicles (EVs) actively participate in inter-cellular crosstalk and have progressively emerged as key players of organized communities of cells within multicellular organisms in health and disease. For these reasons, EVs are attracting the attention of many investigators across different biomedical fields. In this scenario, the possibility to study specific placental-derived EVs in the maternal peripheral blood may open novel perspectives in the development of new early biomarkers for major obstetric pathological conditions. Here we reviewed the involvement of EVs in feto–maternal crosstalk mechanisms, both in physiological and pathological conditions (preeclampsia, fetal growth restriction, preterm labor, gestational diabetes mellitus), also underlining the usefulness of EV characterization in maternal–fetal medicine.

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Placental Syncytiotrophoblast-Derived Extracellular Vesicles Carry Active NEP (Neprilysin) and Are Increased in Preeclampsia

Abstract: Please refer to published version for the most recent bibliographic citation information. If a published version is known of, the repository item page linked to above, will contain details on accessing it.

Cited by 101 publications

References 27 publications

Exosomes as Messengers between Mother and Fetus in Pregnancy

Exosomes as Messengers between Mother and Fetus in Pregnancy

Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

Extracellular Vesicles in Feto–Maternal Crosstalk and Pregnancy Disorders

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