Placental Transfer of Non-Esterified Fatty Acids in Normal and Diabetic Pregnancy

Thomas, Chantal

doi:10.1159/000242638

Cited by 30 publications

(12 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased concentration of NEFA in fetal blood of the type I DM pregnancies is probably caused by increased delivery from the maternal circulation, because an increased maternofetal gradient has been reported in diabetes (28). An abundant supply of NEFA to the fetus may be an important factor stimulating synthesis of other lipid moieties, and in this study the NEFA concentration in the fetoplacental circulation of type I DM correlated significantly with other lipids and apolipoproteins.…”

Section: Discussionsupporting

confidence: 61%

Fetal and Maternal Lipoprotein Metabolism in Human Pregnancy Complicated by Type I Diabetes Mellitus1

Kilby

Neary

Mackness

et al. 1998

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Serum lipid, apolipoprotein concentration, and lipoprotein composition were determined in maternal and umbilical venous cord blood at delivery by elective Cesarean section (CS) in 10 singleton, full-term pregnancies with maternal insulin-dependent diabetes mellitus (type I DM), which predated pregnancy, and in 22 nondiabetic pregnancies. The objectives of the study were to determine the influence of maternal type I DM, and hence potential fetal overnutrition on fetal lipid metabolism. There were no significant differences in gestational age, fetal weight, or fetal serum insulin concentration between the type I DM group and those with nondiabetic pregnancies, although fetal venous cord blood glucose was 3.4 mmol/L (3.0 -4.5 mmol/L) (median and 25th-75th percentiles) and 2.9 mmol/L (2.0 -3.4 mmol/L), respectively, and maternal Hemoglobin A1c [9.6% (8.2-10.7%) and 6.8% (6.3-7.8%), respectively], was significantly greater in the type I DM subjects (P Ͻ 0.02 and 0.002 respectively). Plasma nonesterified fatty acid ( These results indicate that maternal type I DM may lead to a fetal serum lipoprotein composition more closely resembling that seen in the adult. In type I DM, maternal TG and PL and fetal TC, TG, PL CE, and FC were correlated to NEFA levels (P Ͻ 0.05), but not to glucose, insulin secretion, or maternal control of type I DM. These data suggest that the enhanced supply of NEFA to the fetus in type I DM pregnancies may drive the synthesis of cholesterol as well as

show abstract

Section: Discussionsupporting

confidence: 61%

Fetal and Maternal Lipoprotein Metabolism in Human Pregnancy Complicated by Type I Diabetes Mellitus1

Kilby

Neary

Mackness

et al. 1998

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

“…Triglycerides are energy rich and placental lipases can cleave triglyceride and transfer free fatty acids to the foetus. 21 The combination of an increased energy flux to the foetus and foetal hyperinsulinaemia may explain the increased frequency of large for gestational age infants seen in the obese non-diabetic women in this study.…”

Section: Discussionmentioning

confidence: 67%

Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London

et al. 2001

View full text Add to dashboard Cite

OBJECTIVE:To examine the maternal and foetal risks of adverse pregnancy outcome in relation to maternal obesity, expressed as body mass index (BMI, kg=m 2 ) in a large unselected geographical population. DESIGN: Retrospective analysis of data from a validated maternity database system which includes all but one of the maternity units in the North West Thames Region. A comparison of pregnancy outcomes was made on the basis of maternal BMI at booking. SUBJECTS: A total of 287 213 completed singleton pregnancies were studied including 176 923 (61.6%) normal weight (BMI 20 -24.9), 79 014 (27.5%) moderately obese ) and 31 276 (10.9%) very obese (BMI ! 30) women. MEASUREMENTS: Ante-natal complications, intervention in labour, maternal morbidity and neonatal outcome were examined and data presented as raw frequencies and adjusted odds ratios with 99% confidence intervals following logistic regression analysis to account for confounding variables. RESULTS: Compared to women with normal BMI, the following outcomes were significantly more common in obese pregnant women (odds ratio (99% confidence interval) for BMI 25 -30 and BMI ! 30 respectively): gestational diabetes mellitus (1.68 (1.53 -1.84), 3.6 (3.25 -3.98)); proteinuric pre-eclampsia (1.44 (1.28 -1.62), 2.14 (1.85 -2.47)); induction of labour (2.14 (1.85 -2.47), 1.70 (1.64 -1.76)); delivery by emergency caesarian section (1.30 (1.25 -1.34), 1.83 (1.74 -1.93)); postpartum haemorrhage (1.16 (1.12 -1.21), 1.39 (1.32 -1.46)); genital tract infection (1.24 (1.09 -1.41), 1.30 (1.07 -1.56)); urinary tract infection (1.17 (1.04 -1.33), 1.39 (1.18 -1.63)); wound infection (1.27 (1.09 -1.48), 2.24 (1.91 -2.64)); birthweight above the 90th centile (1.57 (1.50 -1.64), 2.36 (2.23 -2.50)), and intrauterine death (1.10 (0.94 -1.28), 1.40 (1.14 -1.71)). However, delivery before 32 weeks' gestation (0.73 (0.65 -0.82), 0.81 (0.69 -0.95)) and breastfeeding at discharge (0.86 (0.84 -0.88), 0.58 (0.56 -0.60)) were significantly less likely in the overweight groups. In all cases, increasing maternal BMI was associated with increased magnitude of risk. CONCLUSION: Maternal obesity carries significant risks for the mother and foetus. The risk increases with the degree of obesity and persists after accounting for other confounding demographic factors. The basis of many of the complications is likely to be related to the altered metabolic state associated with morbid obesity.

show abstract

“…Fatty acids are released from maternal triglycerides (TG) by lipoprotein lipase on the maternal surface of the placenta (6)(7)(8) and the liberated fatty acids, as well as nonesterified fatty acids (NEFA) from the circulation, can be utilized by the placenta. The placental transfer of fatty acids is considered a complex process that involves their binding to membrane proteins and cytoplasmatic transport proteins (8).…”

mentioning

confidence: 99%

In vivo investigation of the placental transfer of 13C-labeled fatty acids in humans

Larqué¹,

Demmelmair²,

Berger

et al. 2003

Journal of Lipid Research

114

View full text Add to dashboard Cite

show abstract

Placental Transfer of Non-Esterified Fatty Acids in Normal and Diabetic Pregnancy

Cited by 30 publications

References 56 publications

Fetal and Maternal Lipoprotein Metabolism in Human Pregnancy Complicated by Type I Diabetes Mellitus1

Fetal and Maternal Lipoprotein Metabolism in Human Pregnancy Complicated by Type I Diabetes Mellitus1

Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London

In vivo investigation of the placental transfer of 13C-labeled fatty acids in humans

Contact Info

Product

Resources

About