Placental Transfer of Perchlorate and Triiodothyronine in the Guinea Pig

Postel, Sholem

doi:10.1210/endo-60-1-53

Cited by 30 publications

(7 citation statements)

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“…Greater antigoitrogenic effects of T4 than T3 was interpreted as increased placental T4 permeability. Postal [39], on the other hand, concluded that T3 did not cross the placenta because its administration to pregnant guinea pigs failed to prevent percholorateinduced fetal goitrogenesis.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Thyroxine Exchange in Pregnant Sheep

Robin¹,

Selenkow²,

Fang³

et al. 1972

Horm Res Paediatr

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Radioisotopic exchange studies in pregnant sheep support the concept of a small but significant bidirectional transplacental thyroxine flux between mother and fetus in the last bimester. The direction and extent of this transfer is not known. There appears to be a rapid and appreciable deiodination of the administered radioactive thyroxine, but no indication that this iodide appeared to any measurable amount as radiothyroxine. The relatively small quantities of radioactive thyroxine transferred become quite significant when compared to the extremely small concentrations of free thyroxine presented to each placental interface.

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Section: Discussionmentioning

confidence: 99%

Bidirectional Thyroxine Exchange in Pregnant Sheep

Robin¹,

Selenkow²,

Fang³

et al. 1972

Horm Res Paediatr

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“…Most investigations of placental permeability to thyroxine have been confined to the passage from maternal to foetal circulation as shown by morphological changes produced in the foetal thyroid (Petersen & Young, 1952;Postel, 1957). In the present experiments a fine polythene catheter was threaded through a superficial hind limb vein into the foetal inferior vena cava under pentobarbitone anaesthesia in six ewes.…”

Section: Laboratory Cambridgementioning

confidence: 91%

Proceedings of the Physiological Society, 12–13 December 1969, Royal College of Surgeons' Meeting: Demonstrations

1970

The Journal of Physiology

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“…Hormone synthesis in the fetal thyroid is dependent on maternally supplied iodide [30]. It has been demonstrated that perchlorate will cross the placenta of gravid guinea pigs to the fetus [31]. Perchlorate crossing the placenta from mother to fetus also could reduce fetal thyroid hormone concentrations.…”

Section: Tissue Residuesmentioning

confidence: 99%

Thyroid function and reproductive success in rodents exposed to perchlorate via food and water

Smith

Severt

Jackson

et al. 2006

Environmental Toxicology and Chemistry

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The purpose of the present study was to determine if exposure to perchlorate via food items would have effects on mammals similar to those caused by exposure through drinking water at approximately equivalent doses. Prairie voles (Microtus ochrogaster) and deer mice (Peromyscus maniculatus) were used to assess the potential toxicity of perchlorate-contaminated food items. Voles and mice were divided randomly into three treatment groups--perchlorate-contaminated food (PCF), perchlorate-contaminated water (PCW), and control groups--such that each treatment group contained equal numbers of males and females. Rodents in PCF treatment groups were fed chow formulated with soybean plant matter that had been grown with perchlorate-contaminated irrigation water. Individuals in the control and PCF groups were provided distilled/deionized drinking water, whereas the PCW group received drinking water containing sodium perchlorate. Only slight differences among treatment groups were observed in a variety of endpoints, including reproductive success, tissue perchlorate concentrations, thyroid hormone concentrations, and thyroid histology. However, trends observed in the present study suggest that perchlorate exposure via water may result in slightly greater effects than exposure to perchlorate via food. These data and recent reports of perchlorate in a wide variety of food items indicate that exposure via food intake is an important consideration when examining cumulative risk among humans, livestock, and wildlife.

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Placental Transfer of Perchlorate and Triiodothyronine in the Guinea Pig

Cited by 30 publications

References 0 publications

Bidirectional Thyroxine Exchange in Pregnant Sheep

Bidirectional Thyroxine Exchange in Pregnant Sheep

Proceedings of the Physiological Society, 12–13 December 1969, Royal College of Surgeons' Meeting: Demonstrations

Thyroid function and reproductive success in rodents exposed to perchlorate via food and water

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