Placental Transport of Maternal Immunoglobulin G

Palfi, Miodrag; Selbing, Anders

doi:10.1111/j.1600-0897.1998.tb00329.x

Cited by 61 publications

(48 citation statements)

References 11 publications

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“…HERZ et al [9] proposed several mechanisms of prenatal regulation of foetal immunity including: transfer of antibodies, transfer of immune complexes, and transfer of cytokines or other soluble molecules via the placental membrane. Although allergenspecific maternal IgG might be a candidate for a foetal-maternal interface [20,21], transplacental transfer of allergen-specific IgG was not considered to be a major mechanism for maternal regulation of allergen-specific immunity in infancy [7]. WARNER et al [8] reported that the concentration of IL-10 in the amniotic fluid differed according to the atopy status of the mother.…”

Section: Discussionmentioning

confidence: 99%

Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates

Heinrich¹,

Bolte²,

Hölscher³

et al. 2002

Eur Respir J

179

123

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on behalf of the LISA study group Allergens and endotoxin on mothers9 mattresses and total immunoglobulin E in cord blood of neonates. J. Heinrich, G. Bolte, B.Hölscher, J. Douwes, I. Lehmann, B. Fahlbusch, W. Bischof, M. Weiss, M. Borte, H-E. Wichmann, on behalf of the LISA study group. #ERS Journals Ltd 2002. ABSTRACT: The current authors examined whether mite and cat allergen and bacterial endotoxin levels in dust of the mothers9 mattresses were associated with cord blood immunoglobulin (Ig)E (CB-IgE) levels in newborns.Data from 1,332 term and normal weight neonates, from an ongoing birth cohort study, Influences of life-style related factors on the immune system and the development of allergies in childhood (LISA), with complete information on exposure to biocontaminants in mattress dust and CB-IgE were analysed. (4th quartile) were chosen as cut-offs. Nonparametric smoothing (generalised additive models) showed statistically significant confounder-adjusted associations between elevated CB-IgE levels (o0.45 kU?L -1 ) and log-transformed exposures to cat (linear), mite (inverse u-shaped), and endotoxin (u-shaped).After adjustment for covariables, elevated CB-IgE levels (logistic regression using the 1st-4th quartiles of exposure) were positively associated with high cat-allergen exposure and medium exposure to mite allergen, but were inversely associated with exposure to endotoxin. The associations were similar, but somewhat weaker, when 0.35 kU?L -1 was used as cut-off. These results, showing an association between prenatal allergen and endotoxin exposures and immunoglobulin E production, suggest that the development of foetal immune responses may be affected.

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Section: Discussionmentioning

confidence: 99%

Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates

Heinrich¹,

Bolte²,

Hölscher³

et al. 2002

Eur Respir J

179

123

View full text Add to dashboard Cite

show abstract

“…Since antibody transfer occurs mainly during the third trimester of pregnancy, preterm infants have low levels of maternal antibodies (5,21,26,28,31,41,46). Placental transfer has also been found to be less efficient in infants in developing countries than in industrialized countries (22).…”

Section: Discussionmentioning

confidence: 99%

“…Newborns are protected against measles by maternal antibodies actively transferred via the placenta during the last trimester of pregnancy (41,46). These maternal antibodies disappear during the first months of life as the newborn's own immune system develops.…”

Section: Discussionmentioning

confidence: 99%

Kinetics of Decline of Maternal Measles Virus-Neutralizing Antibodies in Sera of Infants in France in 2006

Gagneur

Pinquier

Aubert

et al. 2008

Clin Vaccine Immunol

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The optimal age for measles vaccination is an important health issue, since maternal antibodies may neutralize the vaccine antigen before a specific immune response develops, while delaying vaccination may increase the risk of complicated diseases in infants. However, measles vaccination impacts the duration of protection afforded by transplacental transfer of maternal antibodies: vaccination-induced maternal antibodies disappear faster than disease-induced antibodies. In order to maintain protection against measles in infants, it is important to monitor the dynamics of this phenomenon in vaccinated populations. To assess the current situation in France, a multicenter, prospective seroepidemiological study was conducted in seven French hospitals between October 2005 and January 2007. Maternal measles antibody concentrations from 348 infants 0 to 15 months old were measured using the plaque reduction neutralization assay. Geometric mean concentrations and the percentage of infants with maternal measles antibody concentrations above the protection threshold (>120 mIU/ml) were assessed according to age. Results show that after more than 20 years of routine measles vaccination in France, maternal measles-neutralizing antibodies decrease dramatically in French infants by 6 months of age, from 1,740 mIU/ml for infants 0 to 1 month old to 223 mIU/ml for infants 5 to 6 months old, and that 90% of infants are not protected against measles after 6 months of age. Infant protection against measles could be optimized both by increasing herd immunity through an increased vaccine coverage and by lowering the age of routine vaccination from 12 to 9 months.

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“…The electron spin resonance spectra of the isatin anion radical was also recorded and revealed that the monoanion radical exists in equilibrium with the dianion radical in the solvents employed 560 . DSC thermograms of some alkylisatins were also recorded 558 .…”

Section: Further Spectroscopic Datamentioning

confidence: 99%

“…This property has been exploited for the determination of the level of this aminoacid in pollens [560][561][562][563] and other vegetal materials 564 Scheme 136. The Chemistry of Isatins Vol.…”

Section: Organic Analytical Chemistrymentioning

confidence: 99%

The chemistry of isatins: a review from 1975 to 1999

Silva¹,

Garden²,

Pinto³

2001

J. Braz. Chem. Soc.

860

447

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Isatinas (1H-indol-2,3-diona) são compostos de grande versatilidade sintética, podendo ser utilizados na obtenção de diversos sistemas heterociclos, como derivados indólicos e quinolínicos, o que as tornam importantes matérias-primas na síntese de fármacos. Isatinas também têm sido detectadas em tecidos de mamíferos, o que tem despertado o interesse em seu estudo como moduladores em diversos processos bioquímicos. Os avanços na aplicação de isatinas em síntese orgânica, bem como na compreensão de seus efeitos biológicos e farmacológicos nos últimos vinte e cinco anos encontram-se relatados nesta revisão e seus respectivos materiais suplementares.Isatins (1H-indole-2,3-dione) are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds, such as indoles and quinolines, and as raw material for drug synthesis. Isatins have also been found in mammalian tissue and their function as a modulator of biochemical processes has been the subject of several discussions. The advances in the use of isatins for organic synthesis during the last twenty-five years, as well as a survey of its biological and pharmacological properties are reported in this review and in the accompanying supplementary information.

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Placental Transport of Maternal Immunoglobulin G

Abstract: The fetal IgG concentrations exceed maternal IgG concentrations after the 35th week of pregnancy. The fetal IgG concentrations are extremely low in the beginning of pregnancy, they exceed 2.5 g/L at > 25 pregnancy weeks, and they reach 5 g/L at pregnancy week 30.

Cited by 61 publications

References 11 publications

Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates

Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates

Kinetics of Decline of Maternal Measles Virus-Neutralizing Antibodies in Sera of Infants in France in 2006

The chemistry of isatins: a review from 1975 to 1999

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