Placental transport of metoclopramide: Assessment of maternal and neonatal effects

Intraoperative nausea and vomiting during cesarean section under regional anesthesia

“…No adverse neonatal effects were found as evaluated by Apgar scores, heart rate, systolic blood pressure and neurologic and adaptive capacity scores in the first 24 h of life. 84 Metoclopramide is excreted in human milk. The American Association of Pediatrics has classified metoclopramide as a drug for which the effect on nursing infants is unknown but may be of concern.…”

Effects of omeprazole, with and without metoclopramide, in elective obstetric anaesthesia

“…Nevertheless it is noteworthy that when combined with the two doses of omeprazole 40 mg (group 3), all gastric contents at both aspiration times met our criteria for successful treatment. Metoclopramide does reach the infant [22] and has the potential to cause neurological side effects but none was evident in this study.…”

Comparison of the effects of general and epidural anaesthesia for caesarean section on the neurobehavioural responses of newborn infants

“…In order to eliminate the effects of other medication not related to the anaesthesia, the mothers did not receive any sedatives during the 24 h before the caesarean section. Metoclopramide, which has a beneficial effect on the lower oesophageal sphincter (13) and on gastric volume (14) was used as a preventive measure to reduce the risk of aspiration with GA. Even though metoclopramide crosses the placenta after therapeutic doses, no adverse effects on neonates have been noted (14,15).…”

“…Metoclopramide, which has a beneficial effect on the lower oesophageal sphincter (13) and on gastric volume (14) was used as a preventive measure to reduce the risk of aspiration with GA. Even though metoclopramide crosses the placenta after therapeutic doses, no adverse effects on neonates have been noted (14,15). Thus its use in the GA group does not bias the neurobehavioural results.…”