Placentrex gel used as a surgical wound healing agent: A case report

Abstract

Gingival enlargement is an inflammatory response to plaque present on tooth surfaces or due to factors like drugs and several systemic conditions. In cases where the local factors are responsible and subgingival scaling and root planing do not help, gingivectomy/gingivoplasty is performed which creates a raw wound which heals slowly. Since surgical practice primarily depends upon the healing of these wounds without serious complication and infection occurring, to increase the rate of healing of a postoperative surgical wound, placental extract gel has been used as a therapeutic agent because it has unique pharmacological effects like enhancement of wound-healing, anti-inflammatory action, analgesic effect etc. A variety of substances with biological and therapeutic activity present in human placenta have been isolated and identified as hormones, proteins, glycosaminoglycans, nucleic acids, polydeoxyribonucleotides (PDRNs) etc. which therefore play a major role in the faster healing of a surgical wound.

The Use of Human Placental Extract to Arrest and Restrict the Established Carious Lesions with the Aid of Nano Fibered Local Drug Delivery Systems: A Two Years' Evidence Based Study

“…Stimulation of the circumpulpal odontoblasts with the release of cytokines and recruitment of immunological cells, occur in the early stages of dental caries (10)(11)(12)(13) . The placenta has, recently, been described as a therapeutic agent that caused a strong revolution in medicine (14)(15)(16) . The placental extract has been reported to possess strong immunomodulatory properties, thus playing an important role in immune reactions (22,23) .…”

“…Thus the placental mesenchymal stem cells serve to attenuate T cell activity. Moreover, the placental extract possesses various physiologically powerful growth factors that promote the growth of various body cells such as; liver parenchymalcells; nerve cells; lungs, skin, cornea and tracheal epithelial cells; smooth muscle cells; cartilage cells; vascular endothelial cells and, most importantly, stem cells (14)(15)(16)(17)(18)(19)(20)(21)(22)(23) . Postnatal stem cells are found in almost all body tissues including dental tissues (11,20,21) .…”

“…The unrestricted disease progression results in activation of Th -17 response mediated by M-1 macrophages (11) . This shared immunological pattern induces synergistic pro-inflammatory effects among dental and systemic diseases (11) .The placenta is now described as a substance that will revolutionize modern medicine (14)(15)(16) . Currently, the human placental extract is approved for clinical use (17)(18)(19)(20) .…”