Places and chemistry: Strasbourg—a chemical crucible seen through historical personalities

Stadler, Adrian‐Mihail; Harrowfield, Jack

doi:10.1039/c0cs00197j

Cited by 9 publications

(3 citation statements)

References 636 publications

(131 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The original reaction was discovered by Friedel and Crafts in the late 19th century, as the historical account has been documented in previous literature. 19,20 These reactions are often considered one of the basic organic chemistry reactions, as the reactions represent quintessential examples of electrophilic aromatic substitution covered in most of the undergraduate-level textbooks, 21 and, therefore, have been an important subject in the chemical education community. [22][23][24] Beyond their educational significance, the chemical industry has been relying on these reactions for the production of numerous carbon-based molecules for over a century.…”

Section: Jun Ohatamentioning

confidence: 99%

Friedel–Crafts reactions for biomolecular chemistry

Ohata

2024

Org. Biomol. Chem.

View full text Add to dashboard Cite

show abstract

Section: Jun Ohatamentioning

confidence: 99%

Friedel–Crafts reactions for biomolecular chemistry

Ohata

2024

Org. Biomol. Chem.

View full text Add to dashboard Cite

show abstract

“…The original reaction was discovered by Friedel and Crafts in the late 19 th century, as the historical account has been documented in previous literature. 19,20 The reactions are often considered one of the basic organic chemistry reactions, as the reactions represent quintessential examples of electrophilic-aromatic substitution covered in most of undergraduate-level textbooks, 21 and, therefore, have been an important subject in the chemical education community. [22][23][24] Beyond the educational significance, chemical industry relies on the reactions for production of numerous carbon-based molecules over a century too.…”

Section: Introductionmentioning

confidence: 99%

Friedel-Crafts Reactions for Biomolecular Chemistry

Ohata

2024

Preprint

View full text Add to dashboard Cite

Chemical tools and principles have become central to biological and medical research/applications by leveraging a range of classical organic chemistry reactions. Friedel-Crafts alkylation and acylation are arguably one of the most well-known and used synthetic methods for preparation of small molecules but its use in biological and medical fields are relatively less frequent than the other reactions, possibly owing to the notion about its plausible incompatibility with biological systems. This Review demonstrates advances of Friedel-Crafts alkylation and acylation reactions in a variety of biomolecular chemistry fields. With the discoveries and applications of numerous biomolecule-catalyzed or –assisted processes, the reactions have garnered considerable interests in biochemistry, enzymology, and biocatalysis. Despite the challenges of reactivity and selectivity of biomolecular reactions, the alkylation and acylation reactions demonstrated its utility for construction and functionalization of all the four major biomolecules (i.e., nucleosides, carbohydrates/saccharides, lipids/fatty acids, and amino acids/peptides/proteins), and their diverse applications in biological, medical, and material fields are discussed. As the alkylation and acylation reactions are often fundamental educational components of organic chemistry courses, the Review is intended for both experts and nonexperts by discussing their basic reaction patterns (with the depiction of each reaction mechanism in the Electronic Supplementary Information) and relevant real-world impacts in order to enrich chemical research and education. The significant growth of biomolecular Friedel-Crafts reactions described here is a testament to its broad importance and utility, and the further development and investigation of the reactions will surely be the focus in the organic biomolecular chemistry fields.

show abstract

“…He studied the double sodium and ammonium tartrate salts and concluded that both crystals, grown from optically active and inactive tartrates, † were identical although they did not interact similarly with linearly polarized light in solution. 13 It is said that Pasteur did not believe this paradox and, being offered this racemic acid by Kestner, 14 , 15 he started the detailed analysis of the crystals. Why do two apparently identical chemicals (double sodium‐ammonium tartrate and paratartrate) have a different effect on polarized light?…”

mentioning

confidence: 99%

Pasteur and chirality: A story of how serendipity favors the prepared minds

Vantomme

Crassous

2021

Chirality

View full text Add to dashboard Cite

During the XIXth century, France has been the theater of many discoveries in stereochemistry thanks to prestigious physicists, chemists, and crystallographers. Among them, Louis Pasteur is certainly the father of molecular chirality (the so-called molecular dissymmetry), and because of the exceptionally favored conditions of his famous discovery on the resolution of tartrates, his findings have often been attributed to serendipity. But let us not forget that "in the fields of observation, chance only favors the prepared minds."

show abstract

Places and chemistry: Strasbourg—a chemical crucible seen through historical personalities

Cited by 9 publications

References 636 publications

Friedel–Crafts reactions for biomolecular chemistry

Friedel–Crafts reactions for biomolecular chemistry

Friedel-Crafts Reactions for Biomolecular Chemistry

Pasteur and chirality: A story of how serendipity favors the prepared minds

Contact Info

Product

Resources

About