Plague

Roussos, Dikea

doi:10.1016/s1068-607x(02)00102-6

Cited by 3 publications

(8 citation statements)

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“…The resulting infection quickly spreads to the draining lymph nodes, and the involved lymph nodes show polymorphonuclear leukocyte infiltration [2,13,14]. There is a sudden onset of fever, chills, weakness, and headache, followed by intensely tender enlargement of regional lymph nodes (socalled buboes), usually in the groin, axilla or neck.…”

Section: Plague As a Dangerous Diseasementioning

confidence: 99%

“…The infection will further spill out into the bloodstream and ultimately to other organs such as spleen and liver [2,13,14]. Following extensive bacterial replication in visceral organs, the systemic disease, called septicemic plague, occurs within 2-6 days.…”

Section: Plague As a Dangerous Diseasementioning

confidence: 99%

“…Secondary pneumonic plague resulting from hematogenous spread from the buboes to lung is a dreaded complication with a high mortality rate, manifesting in patients as severe bronchopneumonia, cavitation, or consolidation with production of bloody or purulent sputum [2,13,14]. This form of plague is highly contagious by the airborne route for close contacts, which are at risk for developing primary pneumonic plague within 1-3 days.…”

Section: Plague As a Dangerous Diseasementioning

confidence: 99%

“…The mortality is around 60% for untreated bubonic plague, and approaches 100% for untreated pneumonic and septicemic forms [13,15]. With effective antibiotic therapy, the case fatality rate may be as low as 5% for bubonic plague, while for septicemic plague it may be 33% or higher [13,15,16].…”

Section: Plague As a Dangerous Diseasementioning

confidence: 99%

“…With effective antibiotic therapy, the case fatality rate may be as low as 5% for bubonic plague, while for septicemic plague it may be 33% or higher [13,15,16]. The prognosis is worse in patients with pulmonary involvement.…”

Section: Plague As a Dangerous Diseasementioning

confidence: 99%

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Molecular and physiological insights into plague transmission, virulence and etiology

Zhou

Han

Yang

2006

Microbes and Infection

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Section: Plague As a Dangerous Diseasementioning

confidence: 99%

Section: Plague As a Dangerous Diseasementioning

confidence: 99%

Section: Plague As a Dangerous Diseasementioning

confidence: 99%

Section: Plague As a Dangerous Diseasementioning

confidence: 99%

Section: Plague As a Dangerous Diseasementioning

confidence: 99%

See 3 more Smart Citations

Molecular and physiological insights into plague transmission, virulence and etiology

Zhou

Han

Yang

2006

Microbes and Infection

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Global gene expression profile of Yersinia pestis induced by streptomycin

Qiu

Zhou

Han

et al. 2005

FEMS Microbiology Letters

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Plague, caused by Yersinia pestis, is one of the most dangerous diseases that impressed a horror onto human consciousness that persists to this day. Cases of plague can be normally controlled by timely antibiotic administration. Streptomycin is the first-line antibiotic for plague treatment. In this study, a DNA microarray was used to investigate the changes in the gene expression profile of Y. pestis upon exposure to streptomycin. A total of 345 genes were identified to be differentially regulated, 144 of which were up-regulated, and 201 down-regulated. Streptomycin-induced transcriptional changes occurred in genes responsible for heat shock response, drug/analogue sensitivity, biosynthesis of the branched-chain amino acids, chemotaxis and mobility and broad regulatory functions. A wide set of genes involved in energy metabolism, biosynthesis of small macromolecules, synthesis and modification of macromolecules and degradation of small and macro molecules were among those down-regulated. The results reveal general changes in gene expression that are consistent with known mechanisms of action of streptomycin and many new genes that are likely to play important roles in the response to streptomycin treatment, providing useful candidates for investigating the specific mechanisms of streptomycin action.

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Differential pathogenicity and lethality of bubonic plague (1720–1945) by sex, age and place

Mongillo,

Zedda,

Rinaldo

et al. 2024

Proc. R. Soc. B.

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COVID-19 brought back to the attention of the scientific community that males are more susceptible to infectious diseases. What is clear for other infections—that sex and gender differences influence both risk of infection and mortality—is not yet fully elucidated for plague, particularly bubonic plague, although this knowledge can help find specific defences against a disease for which a vaccine is not yet available. To address this question, we analysed data on plague from hospitals in different parts of the world since the early eighteenth century, which provide demographic information on individual patients, diagnosis and course of the disease in the pre-antibiotic era. Assuming that the two sexes were equally represented, we observe a worldwide prevalence of male cases hospitalized at any age, a result which seems better explained by gender-biased (thus cultural) behaviours than biological sex-related factors. Conversely, case fatality rates differ among countries and geographic macro-areas, while globally, lethality appears slightly prevalent in young females and older adults (regardless of sex). Logistic regression models confirm that the main risk factor for bubonic plague death was the geographical location of the cases and being older than 50 years, whereas sex only showcased a slight trend.

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Plague

Abstract: Primary Care Update for Ob/Gyns 9 (2002) 125-128. doi:10.1016/S1068-607X(02)00102-6Received by publisher: 0000-01-01Harvest Date: 2016-01-04 12:23:24DOI: 10.1016/S1068-607X(02)00102-6Page Range: 125-12

Cited by 3 publications

References 10 publications

Molecular and physiological insights into plague transmission, virulence and etiology

Molecular and physiological insights into plague transmission, virulence and etiology

Global gene expression profile of Yersinia pestis induced by streptomycin

Differential pathogenicity and lethality of bubonic plague (1720–1945) by sex, age and place

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