Plaidoyer pour un renforcement du système de pharmacovigilance au Burkina Faso

Abstract

Large-scale deployment of new medicines has been observed over the last two decades in many Sub-Saharan Africa countries faced with major public health issues such as malaria and HIV/AIDS. However, some of these medicines may be responsible for varying degrees of toxicity, with adverse drug reactions leading to decreased compliance or even discontinuation of treatment. Pharmacovigilance systems therefore had to be set up in these countries, such as in Burkina Faso, West Africa, which initiated the organization of pharmacovigilance activities in 2008. Despite this progress, the systems in place have not yet achieved a sufficient level of performance to deal with drug-related health issues, highlighting the need for further actions. Pharmacovigilance in Burkina Faso can be strengthened at multiple levels: pre-service and in-service training of health workers; the establishment of active surveillance based on sentinel sites; informing the public and raising awareness; and strengthening national coordination.

Serious adverse reactions associated with ivermectin: A systematic pharmacovigilance study in sub-Saharan Africa and in the rest of the World

“…Pharmacovigilance systems are not yet well established in SSA countries. In 2017, only 30% of these countries had specific procedures for the monitoring of ADRs and only 28% had a platform for coordinating pharmacovigilance activities at the national level [38]. Cases of serious adverse events occurring during the ivermectin mass drug administration organized by the onchocerciasis and LF control programs have to be reported by the countries to the Mectizan Donation Program, but the extent to which all relevant observations are recorded in the rural areas where onchocerciasis and LF are endemic and then passed on to the central level is unknown as is the extent to which they are reported into the WHO VigiBase.…”

Adverse reactions with levamisole vary according to its indications and misuse: A systematic pharmacovigilance study

“…Additionally, pharmacovigilance systems are not yet well established in African countries. In 2017, only 30% of these countries had specific procedures for the monitoring of ADRs and only 28% had a national platform for coordinating pharmacovigilance activities 76 . Despite the widespread usage of levamisole in some African, Latin American or Asian countries, there remains little information about its use or potential ADRs arising from this use.…”

“…In 2017, only 30% of these countries had specific procedures for the monitoring of ADRs and only 28% had a national platform for coordinating pharmacovigilance activities. 76 Despite the widespread usage of levamisole in some African, Latin American or Asian countries, there remains little information about its use or potential ADRs arising from this use. However, our analyses suggest a good safety profile of single‐dose levamisole for anthelmintic treatment and its use could be considered in some focal areas where emergence of benzimidazole resistance may occur, due to the high drug pressure caused by mass administration of albendazole or mebendazole.…”

<p>Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso</p>

“…However, with the low rate (7.5%) of patients who voluntarily returned to report AEs (probably due to the lack of interest of the population in the study area), such a notification system may be accompanied by regular community sensitization, training of health workers and implementation of PV focal points with personnel to promote ADR reporting. 10,13,50 Moreover, to build a functional and sustainable PV system based on routine spontaneous reporting, the National Pharmacovigilance Monitoring Committee needs to liaise with the nursing/medical schools to introduce training on PV, especially spontaneous reporting, for students prior to graduation. 10,50 The active surveillance seems to be relevant in term of numbers of AEs reported, but it requires resources that are difficult to mobilize and sustain in resource-limited settings.…”

“…10,13,50 Moreover, to build a functional and sustainable PV system based on routine spontaneous reporting, the National Pharmacovigilance Monitoring Committee needs to liaise with the nursing/medical schools to introduce training on PV, especially spontaneous reporting, for students prior to graduation. 10,50 The active surveillance seems to be relevant in term of numbers of AEs reported, but it requires resources that are difficult to mobilize and sustain in resource-limited settings. In such contexts, the use of the HDSS platform combined with existing resources (such as personnel and an established database which is constantly updated) could be an alternative to reduce the cost of this surveillance.…”