1998
DOI: 10.1002/(sici)1097-0169(1998)40:1<87::aid-cm8>3.0.co;2-c
|View full text |Cite
|
Sign up to set email alerts
|

Plakoglobin induces desmosome formation and epidermoid phenotype in N-cadherin-expressing squamous carcinoma cells deficient in plakoglobin and E-cadherin

Abstract: Pg is a homologue of β‐catenin and Armadillo, the product of the Drosophila segment polarity gene and has been shown to have both adhesive and signaling functions. It interacts with both classic and desmosomal cadherins. Pg interaction with the desmosomal cadherins is essential for desmosome assembly. Its precise role in the classic cadherin complexes is unclear, although Pg‐E–cadherin interaction appears to be necessary for the formation of desmosomes. In addition to cadherins in adhesion complexes, Pg intera… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
31
0

Year Published

1999
1999
2010
2010

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 35 publications
(33 citation statements)
references
References 66 publications
2
31
0
Order By: Relevance
“…Increased Nm23 levels and its membrane localization in SCC9-P cells Plakoglobin expression in SCC9 cells (SCC9-P) induces a mesenchymal-to-epidermoid phenotypic transition (Parker et al, 1998). To identify the underlying molecular mechanism for this phenotypic conversion, we examined the protein and RNA profiles of SCC9 and SCC9-P cells.…”
Section: Resultsmentioning
confidence: 99%
See 4 more Smart Citations
“…Increased Nm23 levels and its membrane localization in SCC9-P cells Plakoglobin expression in SCC9 cells (SCC9-P) induces a mesenchymal-to-epidermoid phenotypic transition (Parker et al, 1998). To identify the underlying molecular mechanism for this phenotypic conversion, we examined the protein and RNA profiles of SCC9 and SCC9-P cells.…”
Section: Resultsmentioning
confidence: 99%
“…Plakoglobin has often been associated with tumorsuppressor activity, although the mechanisms behind this activity remain unclear (Simcha et al, 1996;Pantel et al, 1998;Parker et al, 1998;Winn et al, 2002;Reiger-Christ et al, 2005). More recently, downregulation of plakoglobin was also shown to increase the risk of pulmonary metastasis in soft tissue sarcomas (Kanazawa et al, 2008) and was associated with poor differentiation of oral squamous cell carcinoma and with lymph node metastases (Narkio-Makela et al, 2009), further supporting the idea that plakoglobin functions to suppress metastasis in addition to tumor formation.…”
Section: Plakoglobin Interacts With and Regulates Nm23mentioning
confidence: 95%
See 3 more Smart Citations