Plakophilin3 loss leads to an increase in autophagy and radio-resistance

Chaudhary, Nazia; Joshi, Neha; Doloi, Rinki; Shivashankar, Anusha; Thorat, Rahul; Dalal, Sorab N.

doi:10.1016/j.bbrc.2022.06.060

Cited by 3 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among them, the ROS level was the lowest in the cells immobilized by the PDA-CF/PUF due to the high biocompatibility and ROS clearance ability with the PDA [52]. The enhancement of immobilization capacity was accompanied by an increase in the ability to remove the ROS and an increase in biocompatibility [53]. Excessive ROS levels can lead to oxidative stress and membrane damage of microbial cells, thereby promoting cell apoptosis [30].…”

Section: Effect Of Pda-cf/puf Composite Carrier On Biocompatibility O...mentioning

confidence: 99%

Preparation and Immobilization Mechanism on a Novel Composite Carrier PDA-CF/PUF to Improve Cells Immobilization and Xylitol Production

Wang,

Liu,

Shen

et al. 2024

Foods

View full text Add to dashboard Cite

The preparation of a novel composite carrier of polydopamine-modified carbon fiber/polyurethane foam (PDA-CF/PUF) was proposed to improve cell immobilization and the fermentation of xylitol, which is an important food sweetener and multifunctional food additive. Candida tropicalis was immobilized on the composite carrier by adsorption and covalent binding. The properties and immobilization mechanism of the composite carrier and its effect on immobilized cells were investigated. It showed that the modification of PDA enhanced the loading of CF on the PUF surface and the adhesion of cells on the composite carrier surface. Also, the biocompatibility of carriers to cells was improved. In addition, the introduction of PDA increased the active groups on the surface of the carrier, enhanced the hydrophilicity, promoted the cells immobilization, and increased the xylitol yield. It was also found that expression of the related gene XYL1 in cells was significantly increased after the immobilization of the PDA-CF/PUF composite carrier during the fermentation. The PDA-CF/PUF was an immobilized carrier with the excellent biocompatibility and immobilization performance, which has great development potential in the industrial production of xylitol.

show abstract

Section: Effect Of Pda-cf/puf Composite Carrier On Biocompatibility O...mentioning

confidence: 99%

Preparation and Immobilization Mechanism on a Novel Composite Carrier PDA-CF/PUF to Improve Cells Immobilization and Xylitol Production

Wang,

Liu,

Shen

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…Radiotherapy is commonly used for the treatment of numerous types of cancer. However, the occurrence of radio-resistance diminishes the anti-tumor efficacy of X-ray therapy, further restricting its utilization in clinical practice (184). A comprehensive single-cell analysis was performed to explore the mechanisms underlying the development of radio-resistance.…”

Section: Combination With Radiotherapymentioning

confidence: 99%

Targeting tumor-associated macrophage: an adjuvant strategy for lung cancer therapy

Liu,

Chen,

Gong

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

The emergence of immunotherapy has revolutionized the treatment landscape for various types of cancer. Nevertheless, lung cancer remains one of the leading causes of cancer-related mortality worldwide due to the development of resistance in most patients. As one of the most abundant groups of immune cells in the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play crucial and complex roles in the development of lung cancer, including the regulation of immunosuppressive TME remodeling, metabolic reprogramming, neoangiogenesis, metastasis, and promotion of tumoral neurogenesis. Hence, relevant strategies for lung cancer therapy, such as inhibition of macrophage recruitment, TAM reprograming, depletion of TAMs, and engineering of TAMs for drug delivery, have been developed. Based on the satisfactory treatment effect of TAM-targeted therapy, recent studies also investigated its synergistic effect with current therapies for lung cancer, including immunotherapy, radiotherapy, chemotherapy, anti-epidermal growth factor receptor (anti-EGFR) treatment, or photodynamic therapy. Thus, in this article, we summarized the key mechanisms of TAMs contributing to lung cancer progression and elaborated on the novel therapeutic strategies against TAMs. We also discussed the therapeutic potential of TAM targeting as adjuvant therapy in the current treatment of lung cancer, particularly highlighting the TAM-centered strategies for improving the efficacy of anti-programmed cell death-1/programmed cell death-ligand 1 (anti-PD-1/PD-L1) treatment.

show abstract

“…Additionally, PKP3 directly interacts with p38MAPK to block its translocation to the nucleus, while PKP3 loss promotes its phosphorylated activation and nuclear localization, which finally leads to metastasis and growth of HCT116 colon cancer cells through increasing expression of lipocalin 2 (LCN2) 26,27 . Loss of PKP3 induces autophagy and reactive oxygen species clearance by activating p38MAPK, then increases radioresistance and promotes survival of HCT116 colon cancer cells 28 . In addition, several proteins have been identified to regulate PKP3 expression during tumor metastasis in a variety of cancers.…”

Section: Plakophilin 3 Plays Important Role In Cancer Progressionmentioning

confidence: 99%

“… 26 , 27 Loss of PKP3 induces autophagy and reactive oxygen species clearance by activating p38MAPK, then increases radioresistance and promotes survival of HCT116 colon cancer cells. 28 In addition, several proteins have been identified to regulate PKP3 expression during tumor metastasis in a variety of cancers. N , N ′‐dinitrosopiperazine (DNP), as a carcinogenic factor, increases miR‐149 expression and inhibits the transcriptional activity of the PKP3 gene by promoting the binding of miR‐149 to the 3′‐UTRs of PKP3 to induce invasion and metastasis of 6‐10B nasopharyngeal carcinoma cells.…”

Section: Plakophilin 3 Plays Important Role In Cancer Progressionmentioning

confidence: 99%

Role and function of plakophilin 3 in cancer progression and skin disease

Zhang,

Chen,

Tian

et al. 2023

Cancer Science

View full text Add to dashboard Cite

Plakophilin 3 (PKP3), a component of desmosome, is aberrantly expressed in many kinds of human diseases, especially in cancers. Through direct interaction, PKP3 binds with a series of desmosomal proteins, such as desmoglein, desmocollin, plakoglobin, and desmoplakin, to initiate desmosome aggregation, then promotes its stability. As PKP3 is mostly expressed in the skin, loss of PKP3 promotes the development of several skin diseases, such as paraneoplastic pemphigus, pemphigus vulgaris, and hypertrophic scar. Moreover, accumulated clinical data indicate that PKP3 dysregulates in diverse cancers, including breast, ovarian, colon, and lung cancers. Numerous lines of evidence have shown that PKP3 plays important roles in multiple cellular processes during cancer progression, including metastasis, invasion, tumor formation, autophagy, and proliferation. This review examines the diverse functions of PKP3 in regulating tumor formation and development in various types of cancers and summarizes its detailed mechanisms in the occurrence of skin diseases.

show abstract

Plakophilin3 loss leads to an increase in autophagy and radio-resistance

Cited by 3 publications

References 37 publications

Preparation and Immobilization Mechanism on a Novel Composite Carrier PDA-CF/PUF to Improve Cells Immobilization and Xylitol Production

Preparation and Immobilization Mechanism on a Novel Composite Carrier PDA-CF/PUF to Improve Cells Immobilization and Xylitol Production

Targeting tumor-associated macrophage: an adjuvant strategy for lung cancer therapy

Role and function of plakophilin 3 in cancer progression and skin disease

Contact Info

Product

Resources

About