Planar cell polarity in kidney development and disease

Carroll, Thomas J.; Das, Aditi

doi:10.4161/org.7.3.18320

Cited by 26 publications

(19 citation statements)

References 137 publications

(160 reference statements)

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“…Drosophila imaginal discs elongate and evaginate by a combination of several mechanisms, including cell intercalation, cell shape change, and cell division (Condic et al, 1991; Fristrom, 1976; Taylor and Adler, 2008). Epithelial tubules in the mouse postnatal kidney elongate by polarized cell divisions (Carroll and Das, 2011; Fischer et al, 2006), while embryonic kidney tubules elongate by cell intercalations around the circumference of the tube (Karner et al, 2009), driven (at least in part) by polarized formation and resolution of epithelial rosettes (Lienkamp et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

Distinct Apical and Basolateral Mechanisms Drive Planar Cell Polarity-Dependent Convergent Extension of the Mouse Neural Plate

et al. 2014

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Summary The mechanisms of tissue convergence and extension (CE) driving axial elongation in mammalian embryos, and in particular, the cellular behaviors underlying CE in the epithelial neural tissue, have not been identified. Here we show that mouse neural cells undergo mediolaterally biased cell intercalation and exhibit both apical boundary rearrangement and polarized basolateral protrusive activity. Planar polarization and coordination of these two cell behaviors is essential for neural CE, as shown by failure of mediolateral intercalation in embryos mutant for two proteins associated with planar cell polarity signaling: Vangl2 and Ptk7. Embryos with mutations in Ptk7 fail to polarize cell behaviors within the plane of the tissue, while Vangl2 mutant embryos maintain tissue polarity and basal protrusive activity, but are deficient in apical neighbor exchange. Neuroepithelial cells in both mutants fail to apically constrict, leading to craniorachischisis. These results reveal a cooperative mechanism for cell rearrangement during epithelial morphogenesis.

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Section: Introductionmentioning

confidence: 99%

Distinct Apical and Basolateral Mechanisms Drive Planar Cell Polarity-Dependent Convergent Extension of the Mouse Neural Plate

et al. 2014

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“…52 Primary cilia control the switch from canonical to noncanonical Wnt signaling. Convergent extension (process of cell intercalation by which cells elongate along an axis perpendicular to the proximal-distal axis of the tubule by actively crawling between one another to produce a narrower, longer tubule) and oriented cell division (alignment of the mitotic spindle axis and cell division with the proximal-distal axis of the tubule) establish and maintain the normal tubular diameter under the control of PCP signaling.…”

Section: Epithelial Tubulogenesis and Regulation Of Tubular Diametermentioning

confidence: 99%

Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease

Torres

Harris

2014

Journal of the American Society of Nephrology

244

218

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Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with an abnormal extracellular matrix and alternatively activated interstitial macrophages, and the disruption of mechanisms controlling tubular diameter contribute to cyst formation. Studies with animal models suggest that several diverse pathophysiologic mechanisms, including dysregulation of intracellular calcium levels and cAMP signaling, mediate these cystogenic mechanisms. This article reviews the evidence implicating calcium and cAMP as central players in a network of signaling pathways underlying the pathogenesis of PKD and considers the therapeutic relevance of treatment strategies targeting cAMP signaling.

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“…is not conserved in mouse kidneys. Consistent with this last possibility, unlike Drosophila, in the mouse kidney, Fjx1 does not appear to be expressed in the same cells as Fat4 or Dchs1 (Carroll & Das, 2011; Mao et al, 2011). Further analysis will need to be performed to determine which, if any, of these scenarios is correct.…”

Section: Pcp In Kidney Developmentmentioning

confidence: 72%

The Kidney and Planar Cell Polarity

Carroll

2012

Planar Cell Polarity During Development

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Planar cell polarity (PCP) or tissue polarity describes a coordinated polarity at the plane of the tissue where most or all cells within a tissue are polarized in one direction. It is perpendicular to the apical–basal polarity of the cell. PCP is manifested readily in the Drosophila wing and cuticle bristles, Drosophila eye ommatidia, and mammalian hair and inner ear hair bundles, and less evidently, in cellular processes such as in the coordinated, directional cell movements, and oriented cell divisions that are important for tissue morphogenesis. Several distinct molecular and cellular processes have been implicated in the regulation of PCP. Here, we review potential roles for PCP during mouse kidney development and maintenance, including ureteric bud branching morphogenesis, renal medulla elongation, tubule diameter establishment/maintenance, glomerulogenesis, and response to injury. The potential mechanisms underlying these processes, including oriented cell division and coordinated cell migration/cell intercalation, are discussed. In addition, we discuss some unaddressed research topics related to PCP in the kidney that we hope will spur further discussion and investigation.

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Planar cell polarity in kidney development and disease

Cited by 26 publications

References 137 publications

Distinct Apical and Basolateral Mechanisms Drive Planar Cell Polarity-Dependent Convergent Extension of the Mouse Neural Plate

Distinct Apical and Basolateral Mechanisms Drive Planar Cell Polarity-Dependent Convergent Extension of the Mouse Neural Plate

Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease

The Kidney and Planar Cell Polarity

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