Planar-chiral arene ruthenium complexes: synthesis, separation of enantiomers, and application for catalytic C–H activation

Abstract

Heating tert-butyl-tetraline with [(p-cymene)RuCl2]2 produces the racemic complex [(arene)RuCl2]2, which can be separated into enantiomers by chromatography of its diastereomeric adducts with chiral phosphine ligand. The resolved chiral complex catalyzes...

H8‐BINOL‐Derived Chiral η6‐Benzene Ligands: New Opportunities for the Ruthenium‐Catalyzed Asymmetric C−H Activation

“…[14] During the submission of our manuscript, they reported the synthesis of a planar chiral arene ruthenium complex which could catalyzed the asymmetric CÀ H activation of N-methoxy-benzamides with Nvinyl-amides to afford 3-amino-dihydroisoquinolones in 50-90 % yield with 40-80 % ee. [15] Despite excellent performance of chiral [2.2]paracyclophane ruthenium catalysts in our previous work, they exhibited poor enantioselectivity in many other reactions that we have tried. It is most likely due to their shallow chiral pockets.…”