2021
DOI: 10.1038/s41526-021-00144-w
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Planetary extravehicular activity (EVA) risk mitigation strategies for long-duration space missions

Abstract: Extravehicular activity (EVA) is one of the most dangerous activities of human space exploration. To ensure astronaut safety and mission success, it is imperative to identify and mitigate the inherent risks and challenges associated with EVAs. As we continue to explore beyond low earth orbit and embark on missions back to the Moon and onward to Mars, it becomes critical to reassess EVA risks in the context of a planetary surface, rather than in microgravity. This review addresses the primary risks associated w… Show more

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Cited by 36 publications
(26 citation statements)
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“…Additionally, astronauts within the studied cohort embarked on EVAs during their Shuttle mission which also modifies degree of stressor exposure. While most EVAs are scheduled around solar activity, most galactic cosmic rays (GCRs) are unpredictable, and spacesuit radiation shielding alone may not be enough to mitigate radiation exposure and its associated risks 32 . Considering cancer patients receiving external beam radiation therapy exhibit pronounced CH mutations in DDR genes ( TP53, CHEK2, PPM1D ) along with faster clone growth following cumulative exposure 33 , it can be postulated that exposure to space IR may alter the fitness landscape of observed CH mutations and warrants further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, astronauts within the studied cohort embarked on EVAs during their Shuttle mission which also modifies degree of stressor exposure. While most EVAs are scheduled around solar activity, most galactic cosmic rays (GCRs) are unpredictable, and spacesuit radiation shielding alone may not be enough to mitigate radiation exposure and its associated risks 32 . Considering cancer patients receiving external beam radiation therapy exhibit pronounced CH mutations in DDR genes ( TP53, CHEK2, PPM1D ) along with faster clone growth following cumulative exposure 33 , it can be postulated that exposure to space IR may alter the fitness landscape of observed CH mutations and warrants further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…Space environments expose astronauts to a high level of oxidative stress due to extravehicular and intravehicular activities (EVA/IVA) and depend on reduced gravity, ionizing radiation, and variable atmospheric conditions, such as hyper- and hypoxia and psychophysical stress [ 166 , 167 , 168 , 169 ]. In addition, several studies show how astronauts experience immunodeficiency with impairment of NK cells, redox imbalance, elevated inflammation, elevated granulocytes, inhibited lymphocyte proliferation, and reduced lymphocyte functions, as well as elevated inflammation during low-Earth orbit missions [ 170 , 171 , 172 , 173 , 174 ].…”
Section: Spirulina For Astronauts’ Healthcarementioning
confidence: 99%
“…Planetary EVAs expose astronauts to extreme risks to health, including high-doses of solar radiation, limitations on fluid and nutritional intake, and reliance on life-support systems (Chappell et al, 2017). Analogue missions enable the testing of spacesuits and the rehearsal of space mission designs and protocols to mitigate risks to astronaut health during EVAs (Belobrajdic et al, 2021). Such research makes valuable contributions to health risk reduction for astronauts, including those travelling to Mars (Payler et al, 2019).…”
Section: Accepted Articlementioning
confidence: 99%