Planetary respiratory health for asthma, rhinoconjunctivitis and eczema

Soriano, Joan B.

doi:10.1183/13993003.00440-2022

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…It is reported that bronchial asthma remains the most common noncommunicable lung disease, the prevalence of which is the highest in middle-and low-income countries [75][76][77][78][79]. The danger of this disease is increased during an asthma attack, which, due to the narrowing of the bronchial lumen, significantly impairs lung ventilation and therefore causes the development of hypoxia [80,82].…”

Section: Resultsmentioning

confidence: 99%

“…It has been reported that in those countries in which patients are provided with the necessary amount of ICSs and where asthma is treated with standard course doses of IСSs, asthma mortality is lower than in countries in which patients are not fully provided with ICSs [77,[88][89][90][91]. It has been shown that the current standard treatment of asthma with ICSs is not available in countries in which basic inhaled medications containing ICSs are not available to many patients because of their high cost [75,88]. At the same time, the cost of basic inhaled medications containing corticosteroids is still not decreasing [92][93][94][95].…”

Section: Resultsmentioning

confidence: 99%

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Suffocation in asthma and COVID-19: Supplementation of inhaled corticosteroids with alkaline hydrogen peroxide as an alternative to ECMO

Urakov,

Urakova,

Shabanov

et al. 2023

Preprint

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Suffocation syndrome is the leading cause of hypoxia and mortality in the most common lung diseases, asthma and COVID-19. Inhaled corticosteroids (ICSs) have been shown to be the main-stay of critical care in these diseases. Meanwhile, mortality from strangulated hypoxia is highest in low-income countries because ICSs are not currently available to many patients. Warm alkaline hydrogen peroxide solutions (WAHPSs) have reportedly been invented in recent years to urgently turn thick sputum, mucus, pus, serous fluid, blood clots and many other biological masses con-taining the enzyme catalase into a fluffy oxygenated foam. It has been shown that the mechanism of action of WAHPSs consists in alkaline saponification of lipid and protein-lipid complexes of bi-ological masses and their transformation into oxygen foam, because hydrogen peroxide is urgently decomposed into water and oxygen gas under the action of the biological masses catalase enzyme At that excess oxygen is absorbed into blood through lungs and increases blood oxygen saturation. Based on the described mechanism of action of WAHPSs and the high availability of their ingre-dients, it is suggested that mortality from choking and hypoxia in asthma and COVID-19 can be reduced by combining ICSs with inhaled WAHPSs, especially in poor countries. The essence of the inventions underlying the formation of WAHPSs is given.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Suffocation in asthma and COVID-19: Supplementation of inhaled corticosteroids with alkaline hydrogen peroxide as an alternative to ECMO

Urakov,

Urakova,

Shabanov

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…However, none of these associations were sufficient to fully elucidate the relationship between the identified proteins and asthma. The results showed the associations between SNP and multiple allergic diseases and the co-occurrence of asthma and allergic rhinitis ( 35 ), eczema ( 36 ), and atopic dermatitis ( 37 ). This suggests that the aforementioned diseases may share a common etiology.…”

Section: Discussionmentioning

confidence: 99%

Potential drug targets for asthma identified in the plasma and brain through Mendelian randomization analysis

Wang,

Yan

et al. 2023

Front. Immunol.

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BackgroundAsthma is a heterogeneous disease, and the involvement of neurogenic inflammation is crucial in its development. The standardized treatments focus on alleviating symptoms. Despite the availability of medications for asthma, they have proven to be inadequate in controlling relapses and halting the progression of the disease. Therefore, there is a need for novel drug targets to prevent asthma.MethodsWe utilized Mendelian randomization to investigate potential drug targets for asthma. We analyzed summary statistics from the UK Biobank and then replicated our findings in GWAS data by Demenais et al. and the FinnGen cohort. We obtained genetic instruments for 734 plasma and 73 brain proteins from recently reported GWAS. Next, we utilized reverse causal relationship analysis, Bayesian co-localization, and phenotype scanning as part of our sensitivity analysis. Furthermore, we performed a comparison and protein–protein interaction analysis to identify causal proteins. We also analyzed the possible consequences of our discoveries by the given existing asthma drugs and their targets.ResultsUsing Mendelian randomization analysis, we identified five protein–asthma pairs that were significant at the Bonferroni level (P < 6.35 × 10−5). Specifically, in plasma, we found that an increase of one standard deviation in IL1R1 and ECM1 was associated with an increased risk of asthma, while an increase in ADAM19 was found to be protective. The corresponding odds ratios were 1.03 (95% CI, 1.02–1.04), 1.00 (95% CI, 1.00–1.01), and 0.99 (95% CI, 0.98–0.99), respectively. In the brain, per 10-fold increase in ECM1 (OR, 1.05; 95% CI, 1.03–1.08) and PDLIM4 (OR, 1.05; 95% CI, 1.04–1.07) increased the risk of asthma. Bayesian co-localization found that ECM1 in the plasma (coloc.abf-PPH4 = 0.965) and in the brain (coloc.abf-PPH4 = 0.931) shared the same mutation with asthma. The target proteins of current asthma medications were found to interact with IL1R1. IL1R1 and PDLIM4 were validated in two replication cohorts.ConclusionOur integrative analysis revealed that asthma risk is causally affected by the levels of IL1R1, ECM1, and PDLIM4. The results suggest that these three proteins have the potential to be used as drug targets for asthma, and further investigation through clinical trials is needed.

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How should good lung health be defined at the population and individual levels?

Soriano,

Jenkins

2023

Eur Respir J

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Planetary respiratory health for asthma, rhinoconjunctivitis and eczema

Abstract: More descriptive and analytical epidemiology on asthma, hay fever and eczema are welcome https://bit.ly/3ISD1RQ

Cited by 3 publications

References 17 publications

Suffocation in asthma and COVID-19: Supplementation of inhaled corticosteroids with alkaline hydrogen peroxide as an alternative to ECMO

Suffocation in asthma and COVID-19: Supplementation of inhaled corticosteroids with alkaline hydrogen peroxide as an alternative to ECMO

Potential drug targets for asthma identified in the plasma and brain through Mendelian randomization analysis

How should good lung health be defined at the population and individual levels?

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