Aerodynamically alleviated marine vehicle (AAMV) is a high speed craft equipped with aerodynamic surfaces that operating in ground effect zone provides this craft with the ability to achieve much higher cruising speeds. Reducing the take-off mode of an AAMV is highly desirable. Additionally, it is seen where there is a considerable reserve thrust take-off can occur in the lower get-away speeds that shorten the take-off run and, therefore, is favourable. Accordingly, in this study an attempt has been made to develop a nonlinear mathematical model for an AAMV to simulate accelerations in take-off and landing phases, using semi-empirical equations mainly proposed for mono-hull high-speed craft, which concurrently take into account the hydrostatic, hydrodynamic, aerodynamic and thrust forces. The developed model of dynamics has been well validated against the existing experimental data of an AAMV model test calm water resistance. Finally, the effects of various hydrodynamic and aerodynamic parameters on accelerations and thus total resistance and get-away speed of an AAMV in take-off phase have been investigated. This model has the ability to provide the designers with the valuable data on influence of various hydrodynamic and aerodynamic factors on accelerations of an AAMV in take-off phase, which can be usefully employed to lessen the get-away speed and take-off run.