Planned oocyte cryopreservation: the state of the ART

Cascante, Sarah Druckenmiller; Berkeley, Alan S.; Licciardi, Frederick; McCaffrey, Caroline; Grifo, James A.

doi:10.1016/j.rbmo.2023.103367

Cited by 11 publications

(3 citation statements)

References 87 publications

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“…A successful vitrification program heavily relies on the operators' experience and expertise, therefore, it is critical for the clinics and Lab managers to ensure that a proper and active total quality management system is in place, and the whole program from stimulation, oocyte vitrification, warming and performance of the embryos produced from the vitrified oocytes, is intensely monitored and optimized as a whole and as per operator basis. Every fertility clinic offering oocyte vitrification to their patients should be able to present their patients with their own KPIs in relation to the international standards and make sure that the prospective patients are fully aware of what to expect after warming before they proceed with the treatment for oocyte preservation (11)(12)(13).…”

Section: Vitrification: a Game-changermentioning

confidence: 99%

“…The widespread tendency towards delaying motherhood and the advances in laboratory technologies and cryobiology are encouraging women to consider oocyte vitrification and, by doing so, increase their reproductive autonomy. However, elective oocyte vitrification in relation to the expected prognosis for a life birth is still not clear as the confounding parameters are many and only a limited number of cases after oocyte warming have been reported (27)(28). Moreover, despite the well-documented decrease in fecundity that occurs as a woman ages, reproductive-aged women frequently overestimate the age at which a significant decline in fertility occurs and overestimate the success of assisted reproductive technologies (ART) to circumvent infertility.…”

Section: Oocyte Vitrification For Advanced Maternal Age: Shaping Real...mentioning

confidence: 99%

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Improving Oocyte Freezing for Advanced Maternal Age

CHATZIPARASIDOU

2024

Journal of Reproductive Medicine and Embryology

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Recent advancements in reproductive medicine, specifically in cryobiology and oocyte freezing, have opened new possibilities for women seeking fertility preservation to overcome age-related infertility. This Mini Review aims to outline the expected benefits fertility preservation for non-medical reasons offers to women of advanced maternal age. The review will address current challenges, including determining the optimal number of vitrified oocytes for successful outcomes in planned oocyte cryopreservation, and the need for standardization in the vitrification process. Furthermore, this mini-review will explore concerns and ethical dilemmas arising from the increasing trend of women postponing motherhood, emphasizing the importance of aligning women's expectations with available scientific data to prevent misconceptions and false expectations. Additionally, it will touch upon the welfare of parents and children in light of the increasing age gap among them. Lastly, future developments aiming to enhance the efficiency and accessibility of fertility preservation via automation and the use of AI will be presented.

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Section: Vitrification: a Game-changermentioning

confidence: 99%

Section: Oocyte Vitrification For Advanced Maternal Age: Shaping Real...mentioning

confidence: 99%

Improving Oocyte Freezing for Advanced Maternal Age

CHATZIPARASIDOU

2024

Journal of Reproductive Medicine and Embryology

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“…Since the 2012 committee opinion characterizing oocyte cryopreservation as non-experimental [ 1 ], patients undergoing fertility preservation, either for medical or planning purposes, are among the fastest growing patient populations pursuing assisted reproduction [ 2 ]. Guidance regarding how many oocytes to cryopreserve is usually provided based on extrapolations from large database studies on aneuploidy rates and maternal age [ 3 ] combined with anticipated attrition during fertilization, in vitro embryo development, and transfer success rates after euploid blastocyst transfer [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of a usable blastocyst predictive model using the biomechanical properties of human oocytes

Meyer,

Kort,

Chen

et al. 2024

PLoS ONE

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Purpose The purposes of this study were to determine whether biomechanical properties of mature oocytes could predict usable blastocyst formation better than morphological information or maternal factors, and to demonstrate the safety of the aspiration measurement procedure used to determine the biomechanical properties of oocytes. Methods A prospective split cohort study was conducted with patients from two IVF clinics who underwent in vitro fertilization. Each patient’s oocytes were randomly divided into a measurement group and a control group. The aspiration depth into a micropipette was measured, and the biomechanical properties were derived. Oocyte fertilization, day 3 morphology, and blastocyst development were observed and compared between measured and unmeasured cohorts. A predictive classifier was trained to predict usable blastocyst formation and compared to the predictions of four experienced embryologists. Results 68 patients and their corresponding 1252 oocytes were included in the study. In the safety analyses, there was no significant difference between the cohorts for fertilization, while the day 3 and 5 embryo development were not negatively affected. Four embryologists predicted usable blastocyst development based on oocyte morphology with an average accuracy of 44% while the predictive classifier achieved an accuracy of 71%. Retaining the variables necessary for normal fertilization, only data from successfully fertilized oocytes were used, resulting in a classifier an accuracy of 81%. Conclusions To date, there is no standard guideline or technique to aid in the selection of oocytes that have a higher likelihood of developing into usable blastocysts, which are chosen for transfer or vitrification. This study provides a comprehensive workflow of extracting biomechanical properties and building a predictive classifier using these properties to predict mature oocytes’ developmental potential. The classifier has greater accuracy in predicting the formation of usable blastocysts than the predictions provided by morphological information or maternal factors. The measurement procedure did not negatively affect embryo culture outcomes. While further analysis is necessary, this study shows the potential of using biomechanical properties of oocytes to predict embryo developmental outcomes.

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No guarantees: planned oocyte cryopreservation, not quite an insurance policy

Klipstein,

Kelly,

Lalwani

2024

Arch Gynecol Obstet

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Planned oocyte cryopreservation (OC) has the potential to address the burden of the biological clock, giving women and individuals with ovaries more autonomy in choosing when to have children and with whom. In the United States, the annual number of OC cycles has grown significantly, yet many questions remain regarding planned OC. The field is starting to gather data on the clinical practice and social perspectives around planned oocyte cryopreservation, including the optimal age range at which to offer planned OC, what factors are most predictive of a successful outcome, and the optimal number of oocytes and ovarian stimulation cycles to achieve a live birth. There is a clear need for setting realistic expectations about the chance of success with OC; however, most patients have yet to return to thaw their oocytes, and outcomes data are limited. Clinical models have been developed to predict OC success based on surrogate markers such as age, number of oocytes retrieved, and anti-Müllerian hormone level. Patient education should emphasize the age-related decline in fertility, that eggs do not equal embryos, and that more than one cycle may be needed to obtain sufficient oocytes to have a reasonable chance of future success. While planned OC is not quite an insurance policy against future reproductive challenges, it provides the best option to date for expanding the reproductive window and maximizing reproductive options while navigating individual life circumstances in the context of family building.

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Planned oocyte cryopreservation: the state of the ART

Cited by 11 publications

References 87 publications

Improving Oocyte Freezing for Advanced Maternal Age

Improving Oocyte Freezing for Advanced Maternal Age

Development and evaluation of a usable blastocyst predictive model using the biomechanical properties of human oocytes

No guarantees: planned oocyte cryopreservation, not quite an insurance policy

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