“…Relative to their batch counterparts, continuous processes have drawn less attention in the literature (Shaik et al , 2009). However, a number of modeling approaches have been developed over the years including linear programming (Bertoletti, 1960), differential and integral calculus (Odi and Karimi, 1988), mixed integer and global optimization (Kallrath, 2002, 2005), discrete‐ and continuous‐time formulations (Floudas and Lin, 2004; Neumann et al , 2005), heuristic hierarchical decomposition (Herrmann and Schwindt, 2007), and stochastic process analysis (Tan and Gershwin, 2009). Yet, none of the reviewed works explore the essential features of the formulated research problems.…”