To survive in today's healthcare climate, stakeholders across all mental health disciplines must work to produce empirical evidence that earns their fields' regard by educators, providers, and policy makers. As the field of Medical Family Therapy (MedFT) answers this call, it will be important for researchers to clearly define, characterize, and assess MedFT practice across clinical, operational, and financial arenas of care. In this account, we propose a common lexicon from which to do this, highlighting the following core tenets of MedFT: systems theory, biopsychosocial-spiritual sensitivity in practice, agency, communion, interdisciplinary collaboration, and the three-world model of healthcare. We conclude by offering concrete ways to advance the MedFT research agenda using qualitative, quantitative, and mixed-method approaches.Keywords Collaborative family healthcare Á Integrated healthcare Á Medical Family Therapy Á Research agenda Á Research methods Over the past two decades, Medical Family Therapy (MedFT) has emerged as a distinctive subspecialty of Marriage and Family Therapy. Since its foundation, MedFT has adapted and evolved in response to the dynamic and ever-changing landscapes of healthcare, including the advent of healthcare maintenance organizations, the Patient Protection and Affordable Care Act, and recent calls for patient-centered medical homes. These shifts in care contexts have presented both challenges and opportunities for the development of innovative disciplines with practitioners who specialize in collaborative care. To survive in today's healthcare climate, all mental health disciplines must work harder to produce empirical evidence that contributes to the body of knowledge about the respective and overlapping effectiveness of treatment approaches to earn favor by educators, providers, and policy makers. As we work to answer this call, researchers must clearly define, characterize, and assess MedFT across clinical, operational, and financial arenas of practice. To this end, the two-fold purpose of this paper is: (1) to establish/confirm a lexicon for MedFT research, and (2) to identify research methods (qualitative, quantitative, and mixedmethods) that bear promise to advance the field of MedFT.