Climate change is resulting in significant transformations in mountain areas all over the world, causing the melting of glacier ice, reduction in snow accumulation, and permafrost loss. Changes in the mountain cryosphere are not only modifying flora and fauna distributions but also affecting the stability of slopes in those regions. For all these reasons, and because of the risks these phenomena pose to the population, the dentification of dangerous areas is a crucial step in the development of risk reduction strategies. While several methods and examples exist that cover the assessment and computation of single sub-components, there is still a lack of application of risk assessment due to glacier melting over large areas in which the final result can be directly employed in the design of risk mitigation policies at regional and municipal levels. This research is focused on landslides and gravitational movements on slopes resulting from rapid glacier melting phenomena in the Valle d’Aosta region in Italy, with the aim of providing a tool that can support spatial planning in response to climate change in Alpine environments. Through the conceptualization and development of a GIS-based and multi-criteria approach, risk is then estimated by defining hazard indices that consider different aspects, combining the experience acquired from studies carried out in various disciplinary fields, to obtain a framework at the regional level. This first assessment is then deepened for the Lys River Valley, where the mapping of hazardous areas was implemented, obtaining a classification of buildings according to their hazard score to estimate the potential damage and total risk relating to possible slope instability events due to ice melt at the local scale.