Planning impairments in frontal lobe dementia and frontal lobe lesion patients

Carlin, Danielle J.; Bonerba, Joy; Phipps, Michael; Alexander, Gene E.; Shapiro, Mark B.; Grafman, Jordan

doi:10.1016/s0028-3932(99)00102-5

Cited by 120 publications

(85 citation statements)

References 24 publications

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“…However, it is now doubtful that the reasons for task failure in frontal lobe patients could be characterised as a planning impairment (e.g., Goel & Grafman, 1995;Morris et al, 1997;see Burgess et al, 2005a for review). Moreover, the task is multicomponential (Carlin et al, 2000;Hodgson et al, 2000), psychometrically complex (Welsh et al, 1999(Welsh et al, , 2000 and the frontal lobe contribution to the task may be better characterised as mental imagery (Rowe et al, 2001) and goal conflict resolution (Morris et al, 1997) rather than planning-specific functions. Moreover, what the Tower of London measures may in any case have little relevance to "real-world" planning Goel et al, 1997).…”

Section: Further Examples Of the Problemmentioning

confidence: 99%

The case for the development and use of “ecologically valid” measures of executive function in experimental and clinical neuropsychology

Burgess

Alderman

Forbes

et al. 2006

J Int Neuropsychol Soc

556

416

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This article considers the scientific process whereby new and better clinical tests of executive function might be developed, and what form they might take. We argue that many of the traditional tests of executive function most commonly in use (e.g., the Wisconsin Card Sorting Test; Stroop) are adaptations of procedures that emerged almost coincidentally from conceptual and experimental frameworks far removed from those currently in favour, and that the prolongation of their use has been encouraged by a sustained period of concentration on "construct-driven" experimentation in neuropsychology. This resulted from the special theoretical demands made by the field of executive function, but was not a necessary consequence, and may not even have been a useful one. Whilst useful, these tests may not therefore be optimal for their purpose. We consider as an alternative approach a function-led development programme which in principle could yield tasks better suited to the concerns of the clinician because of the transparency afforded by increased "representativeness" and "generalisability." We further argue that the requirement of such a programme to represent the interaction between the individual and situational context might also provide useful constraints for purely experimental investigations. We provide an example of such a programme with reference to the Multiple Errands and Six Element tests. (JINS, 2006, 12, 194-209.)

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Section: Further Examples Of the Problemmentioning

confidence: 99%

The case for the development and use of “ecologically valid” measures of executive function in experimental and clinical neuropsychology

Burgess

Alderman

Forbes

et al. 2006

J Int Neuropsychol Soc

556

416

View full text Add to dashboard Cite

show abstract

“…Several studies suggest that ToL performance relies heavily on frontal cortex functioning, and left frontal cortex functioning in particular (Baker et al, 1996;Carlin et al, 2000;Dagher, Owen, Boecker, & Brooks, 1999;Elliott, Frith, & Dolan, 1997;Levin et al, 1993Levin et al, , 1994Morris, Ahmed, Syed, & Toone, 1993;Owen, Downes, Sahakian, Polkey, & Robbins, 1990;Rezai et al, 1993;Rowe, Owen, Johnsrude, & Passingham, 2001;Shallice, 1982). These studies employed patients with well-defined brain lesions and normal controls performing the ToL, while using single-positron emission computerized tomography and positron emission tomography.…”

Section: Tower Of Londonmentioning

confidence: 99%

Which Executive Functioning Deficits Are Associated With AD/HD, ODD/CD and Comorbid AD/HD+ODD/CD?

Oosterlaan

Scheres

Sergeant

2005

J Abnorm Child Psychol

169

104

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“…Historically, the role of the prefrontal cortex in complex cognition has been assessed using a small number of problem-solving tasks, including the Tower of London (Carlin et al, 2000;Morris, Ahmed, Syed, & Toone, 1993;Shallice, 1982), Tower of Hanoi (Morris, Miotto, Feigenbaum, Bullock, & Polkey, 1997;Goel & Grafman, 1995), and Wisconsin Card Sorting Task (WCST) (Milner, 1963(Milner, , 1964. Studies of frontal lobe lesion patients' (FLL) performance have demonstrated that each of these tasks emphasizes particular higher-level cognitive functions dependent upon intact frontal lobe function and necessary for successful problem-solving.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Frontal Lobe Lesions on Goal Achievement in the Water Jug Task

Colvin¹,

Dunbar

Grafman

2001

Journal of Cognitive Neuroscience

Self Cite

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Patients with prefrontal cortex lesions are impaired on a variety of planning and problem-solving tasks. We examined the problem-solving performance of 27 patients with focal frontal lobe damage on the Water Jug task. The Water Jug task has never been used to assess problem-solving ability in neurologically impaired patients nor in functional neuroimaging studies, despite sharing structural similarities with other tasks sensitive to prefrontal cortex function, including the Tower of Hanoi, Tower of London, and Wisconsin Card Sorting Task (WCST). Our results demonstrate that the Water Jug task invokes a unique combination of problem-solving and planning strategies, allowing a more precise identification of frontal lobe lesion patients' cognitive deficits. All participants (patients and matched controls) appear to be utilizing a hill-climbing strategy that does not require sophisticated planning; however, frontal lobe lesion patients (FLLs) struggled to make required “counterintuitive moves” not predicted by this strategy and found within both solution paths. Left and bilateral FLLs were more impaired than right FLLs. Analysis of the left hemisphere brain regions encompassed by the lesions of these patients found that poor performance was linked to left dorsolateral prefrontal cortex damage. We propose that patients with left dorsolateral prefrontal cortex lesions have difficulty making a decision requiring the conceptual comparison of nonverbal stimuli, manipulation of select representations of potential solutions, and are unable to appropriately inhibit a response in keeping with the final goal.

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Planning impairments in frontal lobe dementia and frontal lobe lesion patients

Cited by 120 publications

References 24 publications

The case for the development and use of “ecologically valid” measures of executive function in experimental and clinical neuropsychology

The case for the development and use of “ecologically valid” measures of executive function in experimental and clinical neuropsychology

Which Executive Functioning Deficits Are Associated With AD/HD, ODD/CD and Comorbid AD/HD+ODD/CD?

The Effects of Frontal Lobe Lesions on Goal Achievement in the Water Jug Task

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