Plant Alkaloids: Production, Extraction, and Potential Therapeutic Properties

Pereira, Antía G.; Cassani, Lucía; García-Oliveira, Paula; Otero, Paz; Mansoor, Sepidar; Echave, Javier; Xiao, Jianbo; Simal‐Gándara, Jesús; Prieto, Miguel A.

doi:10.1007/978-3-031-18587-8_6

Cited by 10 publications

(6 citation statements)

References 179 publications

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“…They are predominantly solid compounds and possess antioxidant potential, which can be induced in response to both abiotic and biotic stress conditions ( Huang et al., 2020 ; Tan et al., 2021 ). Alkaloids can be categorized into subgroups based on the basic heterocyclic nucleus in their structure which includes pyridine, tropane, isoquinoline, phenanthrene, phenylethylamine, indole, purine, imidazole and terpenoids ( Pereira et al., 2023 ). Despite their biological significance in abiotic stress responses in other plants, alkaloids were relatively understudied in Brassica crops possibly due to their low availability in brassica vegetables.…”

Section: Alkaloidsmentioning

confidence: 99%

Abiotic stress-induced secondary metabolite production in Brassica: opportunities and challenges

Muthusamy,

Lee

2024

Front. Plant Sci.

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Over the decades, extensive research efforts have been undertaken to understand how secondary plant metabolites are affected by genetic, environmental, and agronomic factors. Understanding the genetic basis of stress-response metabolite biosynthesis is crucial for sustainable agriculture production amidst frequent occurrence of climatic anomalies. Although it is known that environmental factors influence phytochemical profiles and their content, studies of plant compounds in relation to stress mitigation are only emerging and largely hindered by phytochemical diversities and technical shortcomings in measurement techniques. Despite these challenges, considerable success has been achieved in profiling of secondary metabolites such as glucosinolates, flavonoids, carotenoids, phenolic acids and alkaloids. In this study, we aimed to understand the roles of glucosinolates, flavonoids, carotenoids, phenolic acids and alkaloids in relation to their abiotic stress response, with a focus on the developing of stress-resilient crops. The focal genus is the Brassica since it (i) possesses variety of specialized phytochemicals that are important for its plant defense against major abiotic stresses, and (ii) hosts many economically important crops that are sensitive to adverse growth conditions. We summarize that augmented levels of specialized metabolites in Brassica primarily function as stress mitigators against oxidative stress, which is a secondary stressor in many abiotic stresses. Furthermore, it is clear that functional characterization of stress-response metabolites or their genetic pathways describing biosynthesis is essential for developing stress-resilient Brassica crops.

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Section: Alkaloidsmentioning

confidence: 99%

Abiotic stress-induced secondary metabolite production in Brassica: opportunities and challenges

Muthusamy,

Lee

2024

Front. Plant Sci.

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“…Most of these compounds were recognised for their anti-inflammatory, antitumor, antibacterial, antifungal, and antiviral activities. [83][84][85] Seven carboxylic acids and derivatives have been tentatively identified and sub-classified into di-carboxylic (mesaconic acid 19), tri-carboxylic (citric acid isomers 2/32/50, 2-hydroxy-2-(2-methoxy-2-oxoethyl) butanedioic acid 14, 2-methylcitric acid 23, 3-(carboxymethyl)-2-hydroxypentanedioic acid 28, dimethyl citrate 37) and hexa-carboxylic (loganin pentaacetate 49) acids and derivatives. Specifically, di-methyl citrate 37 was observed in both ionisation modes with a log 2 fold change value of 7.8 (most abundant in ethanol extract) and was the most discriminatory metabolite of NC-Et (Fig.…”

Section: Papermentioning

confidence: 99%

“…Previous research has extensively underlined on the role played by cinnamic acid derivatives in treating cancer, diabetes, bacterial infections, and neurological disorders. [88][89][90] Of all the tentatively identified metabolites, NC-Et was enriched with 21 compounds (90,37,83,72,71,101,98,102,103,100,104,35,38,94,95,69,65,64,55,96,76), whereas NC-W was enriched with 15 compounds (7,17,99,5,88,22,40,24,10,63,68,4,11,20,26) depending on their polarities.…”

Section: Papermentioning

confidence: 99%

Exploring the broad-spectrum pharmacological activity of two less studied Australian native fruits: chemical characterisation using LCMS-driven metabolomics

Dissanayake,

Alsherbiny,

Stack

et al. 2024

Food Funct.

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“…Alkaloids, a diverse class of secondary metabolites, are widely distributed in nature, with more than 27,000 species identified to date, predominantly originating from the plant kingdom, though relatively few are found in the animal and microbial kingdoms [1]. They typically exhibit strong biological activities, including antitumor, antibacterial, insecticidal, and analgesic effects [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…TeAs are classified as pseudo alkaloids primarily because their biosynthetic origins do not involve the amino acid pathway. Instead, terpenoid moieties in TeAs are biosynthesized from isoprene through the methylerythritol phosphate (MEP) pathway, while nitrogen atoms are typically introduced into the structures of terpenoids in the form of β-aminoethanol, ethylamine, or methylamine [1].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities

Wang,

Xin,

Sun

et al. 2024

Molecules

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Terpenoid alkaloids are recognized as a class of compounds with limited numbers but potent biological activities, primarily derived from plants, with a minor proportion originating from animals and microorganisms. These alkaloids are synthesized from the same prenyl unit that forms the terpene skeleton, with the nitrogen atom introduced through β-aminoethanol, ethylamine, or methylamine, leading to a range of complex and diverse structures. Based on their skeleton type, they can be categorized into monoterpenes, sesquiterpenes, diterpenes, and triterpene alkaloids. To date, 289 natural terpenoid alkaloids, excluding triterpene alkaloids, have been identified in studies published between 2019 and 2024. These compounds demonstrate a spectrum of biological activities, including anti-inflammatory, antitumor, antibacterial, analgesic, and cardioprotective effects, making them promising candidates for further development. This review provides an overview of the sources, chemical structures, and biological activities of natural terpenoid alkaloids, serving as a reference for future research and applications in this area.

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Plant Alkaloids: Production, Extraction, and Potential Therapeutic Properties

Cited by 10 publications

References 179 publications

Abiotic stress-induced secondary metabolite production in Brassica: opportunities and challenges

Abiotic stress-induced secondary metabolite production in Brassica: opportunities and challenges

Exploring the broad-spectrum pharmacological activity of two less studied Australian native fruits: chemical characterisation using LCMS-driven metabolomics

Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities

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