Plant-based biomaterials in tissue engineering

Indurkar, Abhishek; Pandit, Ashish; Jain, Ratnesh; Dandekar, Prajakta

doi:10.1016/j.bprint.2020.e00127

Cited by 54 publications

(31 citation statements)

References 97 publications

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“…Tissue engineering is an interdisciplinary field integrating principles of regenerative medicine and biology to develop biological substitutes that aid in repairing and reinstating organ function [59]. Tissue engineering plays a significant role in regenerative medicine, which holds the ideologies of biocompatible, bio-mimic materials science and engineering to develop native tissue substitutes in order to restore and maintain the homeostasis of damaged skin.…”

Section: Advancement In Tissue Engineeringmentioning

confidence: 99%

Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies

Mazlan

2021

Polymers

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Immediate treatment for cutaneous injuries is a realistic approach to improve the healing rate and minimise the risk of complications. Multifunctional biomaterials have been proven to be a potential strategy for chronic skin wound management, especially for future advancements in precision medicine. Hence, antioxidant incorporated biomaterials play a vital role in the new era of tissue engineering. A bibliographic investigation was conducted on articles focusing on in vitro, in vivo, and clinical studies that evaluate the effect and the antioxidants mechanism exerted by epigallocatechin gallate (EGCG) in wound healing and its ability to act as reactive oxygen species (ROS) scavengers. Over the years, EGCG has been proven to be a potent antioxidant efficient for wound healing purposes. Therefore, several novel studies were included in this article to shed light on EGCG incorporated biomaterials over five years of research. However, the related papers under this review’s scope are limited in number. All the studies showed that biomaterials with scavenging ability have a great potential to combat chronic wounds and assist the wound healing process against oxidative damage. However, the promising concept has faced challenges extending beyond the trial phase, whereby the implementation of these biomaterials, when exposed to an oxidative stress environment, may disrupt cell proliferation and tissue regeneration after transplantation. Therefore, thorough research should be executed to ensure a successful therapy.

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Section: Advancement In Tissue Engineeringmentioning

confidence: 99%

Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies

Mazlan

2021

Polymers

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“…Depending on the esterification degree, pectin can be classified as high or low methoxy pectin [ 21 ]. Pectin is highly available, biodegradable, and non-toxic, which makes it a potential material for biomedical applications [ 22 , 23 ]. Moreover, the mixture of chitosan and pectin forms a polyelectrolyte complex mainly conformed by electrostatic interactions between the amino groups of chitosan and the carboxylic groups of pectin [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Zarandona

Bengoechea

Álvarez‐Castillo

et al. 2021

Gels

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Chitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccharides, as observed by FTIR analysis. Since systems with high concentration of pectin showed aggregations, the system composed of 2 wt% chitosan and 2 wt% pectin (CHI2PEC2) was selected for 3D printing. 3D printed scaffolds showed good shape accuracy, and SEM and XRD analyses revealed a homogeneous and amorphous structure. Moreover, scaffolds were stable and kept their shape and size after a cycle of compression sweeps. Their integrity was also maintained after immersion in PBS at 37 °C, showing a high swelling capacity, suitable for exudate absorption in wound healing applications.

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“…Em relação aos óleos essenciais, seu uso associado ao polímero de quitosana já vem sendo amplamente estudado (El-Tarabily et al, 2021;Hadidi et al, 2020;Râpă et al, 2021;Santos et al, 2019), demonstrando preferência na utilização de materiais vegetais naturais considerados biocompatíveis e biodegradáveis (Indurkar et al, 2021). As inúmeras propriedades farmacológicas que os óleos essenciais possuem os promovem para ser amplamente utilizados na medicina regenerativa, uma vez que são capazes de acelerar o processo de cicatrização de feridas, reduzir os processos infecciosos e inflamatórios, além de apresentar potencial anticancerígeno, antidiabético, antioxidante e cardiovascular (Jugreet et al, 2020).…”

Section: Discussionunclassified

Atividade antimicrobiana da quitosana associada a óleos essenciais na aplicação biomédica: uma revisão integrativa

Brixner

Silva²,

Pollo³

et al. 2022

RSD

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Atualmente o uso de biomateriais voltados à área da saúde está em constante evolução. Sabe-se que o desenvolvimento de materiais utilizando a quitosana, um polímero biocompatível e com ação antimicrobiana, associados aos óleos essenciais, substância natural com inúmeras propriedades biológicas e antimicrobiana, vêm sendo estudado. Diante disso, buscou-se verificar na literatura estudos relacionados à atividade antimicrobiana de biomateriais à base de quitosana associados a diferentes óleos essenciais, voltados a área da saúde. Foi realizada uma revisão de literatura nas bases de dados PubMed e Science Direct, no período de 2018 a 2022, utilizando os descritores "Chitosan" AND "Essential Oil" AND "Antimicrobial Activity" AND "Dressing". Foram encontrados 305 artigos na pesquisa do banco de dados, destes, foram incluídos no estudo oito artigos, em que foi possível dividi-los conforme o produto final em: (1) filme; (2) criogel e; (3) scaffolds nanofibrosos. As técnicas de análise antimicrobiana incluíram o teste de difusão em ágar e concentração inibitória/microbicida mínima. Foi possível verificar que os biomateriais à base de quitosana por si só já apresentaram inibição das cepas microbianas testadas e, quando associados aos óleos essenciais, houve aumento da ação frente às cepas, os tornando promissores para a aplicabilidade biomédica.

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Plant-based biomaterials in tissue engineering

Cited by 54 publications

References 97 publications

Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies

Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Atividade antimicrobiana da quitosana associada a óleos essenciais na aplicação biomédica: uma revisão integrativa

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