Plant-based diets, mediating biomarkers, and mortality risk among adults with diabetes or prediabetes

Tao, Hao-Wei; Han, Wen-Wen; Fang, Fei; Miao, Meng-Yuan; Du, Hong-Zhen; Li, Zeng-Ning; Chen, Jing-Si; Qin, Li-Qiang; Chen, Guo-Chong

doi:10.1039/d3fo04793h

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2024

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Cited by 2 publications

References 34 publications

(45 reference statements)

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Dietary patterns in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study: comparisons across methodologies

Beasley,

Hussain,

Gadgil

et al. 2024

BMJNPH

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Dietary patterns in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study: comparisons across methodologies

Beasley,

Hussain,

Gadgil

et al. 2024

BMJNPH

View full text Add to dashboard Cite

Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

Guo,

Liu,

Liu

et al. 2024

Preprint

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Background Oxidative stress may be relevant in the progression and cardiovascular complications of prediabetes. The oxidative balance score (OBS) is an emerging metric for assessing dietary and lifestyle oxidative stress exposure. The objective of this prospective cohort study from NHANES 1999–2018 was to explore the association of OBS with all-cause and cardiovascular disease (CVD) mortality in people with prediabetes. Methods OBS was composed of 16 dietary components and 4 lifestyle components based on previous research. Prediabetes was diagnosed based on self-reported history or laboratory criteria. Multivariate Cox proportional hazards regression analyses were used to explore these associations and calculate hazard ratios [HR] and 95% confidence intervals [CI]. Results A total of 8256 adult participants with prediabetes were included. Kaplan-Meier survival analysis showed significantly higher all-cause and CVD-related survival in people with prediabetes at higher OBS. After adjusting for all confounders, OBS, dietary OBS, and lifestyle OBS were all inversely associated with all-cause mortality in people with prediabetes (HR and 95% CI 0.959 (0.946,0.973), 0.965 (0.950,0.980), and 0.847 (0.798,0.899), respectively; all p < 0.0001). Higher OBS was associated with significantly lower all-cause mortality (p for trend all < 0.0001). Similar results were observed for CVD mortality. Most associations were linear, whereas the associations of OBS and dietary OBS with CVD mortality were nonlinear. Mediation analyses suggested that several oxidative stress and systemic inflammatory markers mediated these associations. Stratified and sensitivity analyses demonstrated the stability of the findings. Conclusions Adherence to antioxidant dietary and lifestyle patterns assessed by OBS may help prevent excess mortality in population with prediabetes. These effects may be achieved indirectly by influencing oxidative stress and systemic inflammatory markers.

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Plant-based diets, mediating biomarkers, and mortality risk among adults with diabetes or prediabetes

Abstract: Guidelines and interventions highlighting the importance of the increasing intake of minimally-processed, fiber-rich plant foods may promote health and longevity across diverse glycemic groups.

Cited by 2 publications

References 34 publications

Dietary patterns in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study: comparisons across methodologies

Dietary patterns in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study: comparisons across methodologies

Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

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