Plant-Based Drugs and Vaccines for COVID-19

Abstract

The coronavirus SARS-CoV-2 has turned our own health and the world economy upside down. While several vaccine candidates are currently under development, antivirals with the potential to limit virus transmission or block infection are also being explored. Plant production platforms are being used to generate vaccines and antiviral proteins inexpensively and at mass scale. The following review discusses the biology and origins of the current coronavirus pandemic, and describes some of the conventional, synthetic, and plant-based approaches to address the challenge that it presents to our way of life.

Modern World Applications for Nano-Bio Materials: Tissue Engineering and COVID-19

“…Despite all the alternatives shown from 2020 to the present, currently, treatments that have proven to have a real effect in controlling COVID-19 symptoms are Dexamethasone, Remdesivir, Baricitinib in combination with Remdesivir, and Anticoagulation drugs (as heparin or enoxaparin) (Lammers et al, 2020). Other alternatives to treat patients have been convalescent plasma from people who have recovered from COVID-19; Monoclonal antibodies as bamlanivimab (LY-CoV555) and REGN-COV2 developed from the companies Eli Lilly and Regeneron, respectively, and AZD7442 from AstraZeneca (Mahmood et al, 2021). The novel panorama of variants impulses the necessity for specialized tools to test the effects of infection, immune system response, and therapeutic use of drugs and vaccines.…”

Covid-19 ile mücadelede bitkilerin rolü

“…Genomik RNA'sı, tüm RNA virüsleri içerisinde en uzun olanıdır (yaklaşık olarak 26.2-31.7 kb) [9]. Özellikle üst solunum yolu enfeksiyonlarına sebep olan koronavirüs (CoV), genetik materyali tek zincirli RNA olan zarflı virüs grubu olarak tanımlanmaktadır [10]. Yaklaşık 30kb uzunluğundadır.…”

“…Bir koronavirüs partikülü yüzeyinde ortalama 74 adet S proteini bulundurmaktadır [9]. Koronavirüsler ilk olarak 1960'larda tanımlanmış, bu gruba ait farklı virüsler toplumlarda ölümlere neden olan virüs türleri olmuşlardır [10]. Virüsler bu isimlerini, latince taç anlamına gelen "corona" kelimesine benzeyen yuvarlak güneş tacı yapısından almaktadır [12].…”

A review on Effectivity of Plant based vaccines in the treatment of viral diseases

“…The pre-clinical trials of vaccine have shown a positive immune response and will be into Phase-1 human clinical trials very soon 102 . BAT has a production capacity of approximately 1-3 million doses per week of COVID-19 vaccines (they prepared 10M flu vaccines in a month and Ebola vaccine utilizing the same plant based approach 103,104…”