Plant-based meat analogues aggravated lipid accumulation by regulating lipid metabolism homeostasis in mice

Xie, Yunting; Cai, Liuyang; Huang, Zhiji; Shan, Kai; Xu, Xinglian; Zhou, Guanghong; Li, Chunbao

doi:10.26599/fshw.2022.9250081

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…253 An in vivo animal (mice) feeding study reported that consumption of plant-based meat analogs promoted an increase in body weight, lipid deposition, and inflammation relative to consumption of real beef or pork, which was attributed to upregulation of specific genes. 254 Another animal study suggested that consumption of plant-based meat analogs promoted increased food consumption compared to real meat by increasing the levels of appetite-stimulating factors, 255 which could lead to overeating and obesity.…”

Section: Alternative Protein Sourcesmentioning

confidence: 99%

Designing a More Sustainable and Environmentally Friendly Food Supply: A Roadmap for Future Food and Agricultural Research

McClements

2024

ACS Sustainable Resour. Manage.

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There is an urgent need to change the way we produce, distribute, and consume foods due to several adverse effects the modern food supply is having on the environment, including greenhouse gas emissions, pollution, freshwater use, land use, and biodiversity loss. Concerted efforts are therefore required by food scientists around the world to generate the scientific knowledge and technological advances needed to develop a more sustainable global food supply chain. The purpose of this article is to highlight some of the most critical areas where research is needed to improve the sustainability and reduce the adverse environmental impact of food production. These areas include enhanced agricultural crops and livestock animals, improved fertilizers, pesticides, and antibiotics, reduced food and agricultural waste, conversion of waste streams into energy and valuable materials, alternative protein sources, and advanced food packaging materials, as well as many others. A range of advanced technologies is leading to important advances in many areas of food science and technology, including gene editing, nanotechnology, precision fermentation, biotechnology, and food architecture. An important objective of this article is to stimulate research and development in this important area so as to create a more sustainable and environmentally friendly global food supply system.

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Section: Alternative Protein Sourcesmentioning

confidence: 99%

Designing a More Sustainable and Environmentally Friendly Food Supply: A Roadmap for Future Food and Agricultural Research

McClements

2024

ACS Sustainable Resour. Manage.

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Real meat shows good performance in maintaining colonic barrier function at a recommended amount of intake in mice

Xie,

Cai,

Ibeogu

et al. 2024

Food Frontiers

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This study aimed to investigate the effects and underlying mechanisms of real meat and plant‐based meat analogs on intestinal barrier function. Methods including PacBio sequencing, HPLC, histological observation, western blotting, and RT‐qPCR were jointly applied. The results indicated that the 20‐day intake of real meat and plant‐based meat analogs did not induce pathological changes in the colon of mice. However, when the feeding period was extended to 68 days, inflammatory infiltration was observed in the colon tissue of mice fed plant‐based meat analogs. In contrast, the intake of real meat for 68 days performed better in maintaining colonic barrier function by reducing cell apoptosis, increasing the number of goblet cells and mucin secretion, and upregulating the expression of tight junction proteins. High‐throughput sequencing revealed that the intake of real meat significantly altered the composition of the gut microbiota, reducing pro‐inflammatory bacteria (such as Bacteroides, Desulfovibrio, or Colidextribacter) or pathogenic bacteria (such as Mucispirillum and Helicobacter) while increasing beneficial bacteria (such as Lactobacillus, Bifidobacterium, or Roseburia). Additionally, the consumption of real meat markedly decreased protein fermentation in the colon, leading to lower levels of cadaverine, putrescine, and spermine. These changes associated with real meat consumption reduced the activation of the pro‐inflammatory pathway (lipopolysaccharide/Toll‐like receptor 4/nuclear factor kappa B), ultimately maintaining colonic homeostasis in mice. Collectively, the findings suggest that the proper intake of real meat is more beneficial for colon health in mice compared to plant‐based meat analogs.

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Comparison of nutritional profile between plant-based meat analogues and real meat: A review focusing on ingredients, nutrient contents, bioavailability, and health impacts

Xie,

Cai,

Zhou

et al. 2024

Food Research International

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Plant-based meat analogues aggravated lipid accumulation by regulating lipid metabolism homeostasis in mice

Cited by 6 publications

References 42 publications

Designing a More Sustainable and Environmentally Friendly Food Supply: A Roadmap for Future Food and Agricultural Research

Designing a More Sustainable and Environmentally Friendly Food Supply: A Roadmap for Future Food and Agricultural Research

Real meat shows good performance in maintaining colonic barrier function at a recommended amount of intake in mice

Comparison of nutritional profile between plant-based meat analogues and real meat: A review focusing on ingredients, nutrient contents, bioavailability, and health impacts

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