Plant Based Natural Products and Breast Cancer: Considering Multi-Faceted Disease Aspects, Past Successes, and Promising Future Interventions

Tobin, Gailene; Kalupahana, Ruwani; Kulka, Marianna

doi:10.5772/55794

Cited by 4 publications

(2 citation statements)

References 404 publications

(393 reference statements)

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“…Menurut Mohanakumara et al, ( 2010) rohitukin pada Dysoxylum adalah prekursor flavopiridol, senyawa antikanker yang potensial. Flavopiridol pada D.binectariferum merupakan inhibitor dari MMP-2 dan MMP-9 pada sel kanker payudara MCF-7 (Tobin et al 2012). Kulit batang D. binectariferum menghasilkan rohitukin yang sangat efektif terhadap ovarium dan kanker payudara (Lakshmi et al 2007).…”

Section: Pendahuluanunclassified

SENYAWA STEROID DARI KULIT BATANG Dysoxylum alliaceum DAN AKTIVITASNYA TERHADAP SEL KANKER PAYUDARA MCF-7

2015

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Dysoxylum merupakan salah satu genus yang memiliki metabolit sekunder dan aktivitas yang beragam, salah satu aktivitas yang menarik adalah mampu bertindak sebagai agen P-gp pada sel kanker payudara MCF-7. Kulit batang D.alliaceum dimaserasi berturut-turut dengan n-heksana, etil asetat dan metanol. Ekstrak n-heksan dipisahkan dan dimurnikan dengan berbagai teknik kromatografi dipandu dengan analisis kromatografi lapis tipis diperoleh dua senyawa stigmast-5-en-3β-ol (1), stigmasterol (2). Struktur kimia senyawa tersebut telah ditetapkan berdasarkan intrepretasi data-data spektroskopi dan dibandingkan dengan data spektra dari penelitian sebelumnya. Semua isolat senyawa dievaluasi aktivitas sitotoksiknya terhadap sel kanker payudara MCF-7. Senyawa 1 dan 2 dirujuk dari literatur menunjukkan aktivitas kuat dengan IC 50 8,65 µg/mL.

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Section: Pendahuluanunclassified

SENYAWA STEROID DARI KULIT BATANG Dysoxylum alliaceum DAN AKTIVITASNYA TERHADAP SEL KANKER PAYUDARA MCF-7

2015

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“…Kumingianol triterpenoid isolated from D. cumingianum can inhibit P-gp in MCF-7 cancer cells so that it can be used as an agent for chemotherapy [8]. According to [9] rohitukin in Dysoxylum is a precursor to flavopiridol, a potential anticancer compound [9]. Flavopiridol in D. binectariferum is an inhibitor of MMP-2 and MMP-9 in MCF-7 breast cancer cells [10].…”

Section: Introductionmentioning

confidence: 99%

6,7-dimethoxydihydrocoumarin Compound from Ethyl Acetate Extracts from Steambarks Dysoxylum Alliaceum and Cytotoxic Activity Against P-388

Nurcahyanti¹,

Rahma

2022

J. Trop. Pharm. Chem.

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Dysoxylum is a genus that has a variety of secondary metabolites. Research on various species of this genus is always growing and producing compounds that have interesting structures and activities, until now many compounds of the terpenoid group, chroman alkaloids, limonoids, sesquiterpenes, flavonoids, steroids, protolimonoids and sulfur have been reported. which is very interesting. One of the Dysoxylum species that has a variety of secondary metabolites is D. alliaceum. The purpose of this study was to obtain secondary metabolites of D. alliaceum bark. The bark of D. alliaceum was macerated successively with n-hexane, ethyl acetate and methanol. The ethyl acetate extract was separated and purified by various chromatographic techniques and was characterized using spectroscopic methods including, ultraviolet, infrared, NMR and mass spectroscopy and guided by thin layer chromatographic analysis to obtain the compound 6,7-dimethoxydyhidrocoumarin and the proposed biogenesis. The chemical structure of these compounds has been determined based on the interpretation of spectroscopic data and compared with spectral data from previous studies. Cytotoxic activity test against P-388 MTT leukemia cells obtained an IC50 of 39.210 g/mL and was declared inactive.

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Molecular Mechanisms Underlying Breast Cancer and Role of Plant Products in Targeted Therapy

Singhal

Singh

et al. 2021

Discovery and Development of Anti-Breast Cancer Agents From Natural Products

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Plant Based Natural Products and Breast Cancer: Considering Multi-Faceted Disease Aspects, Past Successes, and Promising Future Interventions

Cited by 4 publications

References 404 publications

SENYAWA STEROID DARI KULIT BATANG Dysoxylum alliaceum DAN AKTIVITASNYA TERHADAP SEL KANKER PAYUDARA MCF-7

SENYAWA STEROID DARI KULIT BATANG Dysoxylum alliaceum DAN AKTIVITASNYA TERHADAP SEL KANKER PAYUDARA MCF-7

6,7-dimethoxydihydrocoumarin Compound from Ethyl Acetate Extracts from Steambarks Dysoxylum Alliaceum and Cytotoxic Activity Against P-388

Molecular Mechanisms Underlying Breast Cancer and Role of Plant Products in Targeted Therapy

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