Plant-based Rasayana drugs from Ayurveda

Balasubramani, Subramani Paranthaman; Venkatasubramanian, Padma; Kukkupuni, Subrahmanya Kumar; Patwardhan, Bhushan

doi:10.1007/s11655-011-0659-5

Cited by 109 publications

(66 citation statements)

References 26 publications

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“…In recent years, traditional medicines have been playing more and more important roles in the maintenance of health, the prevention and treatment of diseases, and plant-based drug discovery [4–8]. Chinese herbal medicine or its products have been administered widely for treating CHD in China.…”

Section: Introductionmentioning

confidence: 99%

OralPanax notoginsengPreparation for Coronary Heart Disease: A Systematic Review of Randomized Controlled Trials

Shang

Liu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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This systematic review aims to evaluate current evidence for the benefit and side effect of oral Panax notoginseng preparation for coronary heart disease (CHD). We included 17 randomized clinical trials (17 papers and 1747 participants). Comparing with no intervention on the basis of conventional therapy, oral Panax notoginseng did not show significant effect on reducing cardiovascular events, but it could alleviate angina pectoris (including improving the symptoms of angina pectoris [RR 1.20; 95% CI 1.12 to 1.28; 7 trials, n = 791], improving electrocardiogram [RR 1.35; 95% CI 1.19 to 1.53; 8 trials, n = 727], decreasing the recurrence of angina pectoris [RR 0.38; 95% CI 0.16 to 0.94; 1 trials, n = 60], duration of angina pectoris [RR −1.88; 95% CI −2.08 to −1.69; 2 trials, n = 292], and dosage of nitroglycerin [MD −1.13; 95% CI −1.70 to −0.56; 2 trials, n = 212]); oral Panax notoginseng had no significant difference compared with isosorbide dinitrate on immediate effect for angina pectoris [RR 0.96; 95% CI 0.81 to 1.15; 1 trial, n = 80]. In conclusion, oral Panax notoginseng preparation could relieve angina pectoris related symptoms. However, the small sample size and potential bias of most trials influence the convincingness of this conclusion. More rigorous trials with high quality are needed to give high level of evidence, especially for the potential benefit of cardiovascular events.

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Section: Introductionmentioning

confidence: 99%

OralPanax notoginsengPreparation for Coronary Heart Disease: A Systematic Review of Randomized Controlled Trials

Shang

Liu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…For example, it is indicated that Rasayana drugs act through nutrition dynamics, for example, improving the quality of plasma (Rasa enhancing), normalizing the digestion and metabolism ( Agni ), and improving tissue perfusion of nutrients ( Srotas ) at molecular level. [37] This gap provides an opportunity for further research on Rasayanas at Dhatu level using stem cells.…”

Section: Ayurveda and Translational Stem Cells Research: Experimentalmentioning

confidence: 99%

Insights from Ayurveda for translational stem cell research

Joshi¹,

Bhonde²

2014

J Ayurveda Integr Med

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Ayurveda, the traditional Indian system of medicine has given great emphasis to the promotion of health. Ayurveda therapies are based on restoration of body balance and nourishment of dhatus or tissues. Rasayana concept of Ayurveda explains tissue regeneration and cell renewal. The drugs and therapies explained as rasayana provide research opportunities for biology of regeneration. Specific rasayana stimulate and nourish respective dhatus. Interpretation of this description offers clues for specific differentiation of stem cells with appropriate extract. The preliminary experiments on Medhya drugs suggest neuronal stem cells differentiation. Authors highlight the potential of Ayurveda and its possible contributions in regenerative medicine. Authors propose a protocol based on integrative approach derived from Ayurveda concepts and current understanding of regenerative medicine. The advanced understanding about adult and embryonic stem cells along with concepts of regeneration in Ayurveda has immense potential in the development of regenerative medicine.

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“…Traditional literature describes Rasayanas as interventions that reverse naturally occurring senility and improve mental competence, increase immunity against diseases, provide vitality and luster to the body and increase longevity [2]. As Ayurveda, Rasayanas are supposed to act holistically on the body by (i) improving the process of digestion and metabolism (Agni), increasing bio-availability of nutrients, (ii) optimizing the micro-circulation of nutrients through the body channels (Srotas), and (iii) enhancing the nutritive value of the plasma that becomes re-generated (Rasadhatu) [3,4]. Natural products and herbal medicines are promising sources of new agents and interesting candidates for the development of complementary and alternative treatments to conventional drug regimens.…”

Section: Introductionmentioning

confidence: 99%

Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae

et al. 2017

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The traditional Indian medicine, Ayurveda, provides insights and practical solutions towards a healthy life style. Rasayana is a branch of Ayurveda known for preserving and promoting health, enhancing the quality of life and delaying the aging process. In the traditional knowledge, the Rasayana herb, Chlorophytum borivilianum (C. borivilanum) is regarded as a general health promoting tonic that delays aging and increases lifespan, cognitive function and physical strength. Aging is a complex and multifactorial physiological phenomenon that manifests itself over a wide range of biological systems, tissues, and functions. Longevity is an obvious marker of physiological aging. Simple model systems such as the single-cell budding yeast Saccharomyces cerevisiae (S. cerevisiae) and the nematode, Caenorhabditis elegans (C. elegans) are widely used to study the aging process and longevity. Here, we show that a polysaccharide fraction obtained from C. borivilianum increases the lifespan of S. cerevisiae and C. elegans, using an automated screening platform (ChronoscreenTM). Chemical analysis of this extract revealed a low molecular weight polysaccharide of 1000 Da, predominantly comprising Glu1→6Glu linkage. This polysaccharide showed significant dose-dependent extension of the median lifespan of S. cerevisiae by up to 41% and of the median lifespan of C. elegans by up to 10%. Taking cue from these results and the traditionally described benefits of Rasayanas on skin rejuvenation, we tested in vitro the polysaccharide for potential skin benefits. In a keratinocyte culture, we observed that this polysaccharide increased cell proliferation significantly, and induced synthesis of hyaluronic acid (HA), a well-known extracellular matrix component. Furthermore, when added to culture medium of human reconstructed epidermis, we observed an enhanced production of epidermal markers, e.g. CD44 and HA that are otherwise diminished in aged skin. Together, these results suggest that in addition to life-span extension of S. cerevisiae and C. elegans, a polysaccharide from the Rasayana herb, C. borivilianum may have beneficial effects on skin aging parameters.

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Plant-based Rasayana drugs from Ayurveda

Cited by 109 publications

References 26 publications

OralPanax notoginsengPreparation for Coronary Heart Disease: A Systematic Review of Randomized Controlled Trials

OralPanax notoginsengPreparation for Coronary Heart Disease: A Systematic Review of Randomized Controlled Trials

Insights from Ayurveda for translational stem cell research

Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae

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