Plant derived and dietary phenolic antioxidants: Anticancer properties

Roleira, Fernanda M.F.; Silva, E. J. Tavares da; Varela, Carla; Costa, Saul C.; Silva, Tiago; Garrido, Jorge; Borges, Fernanda

doi:10.1016/j.foodchem.2015.03.039

Cited by 370 publications

(218 citation statements)

References 83 publications

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“…The anti-proliferative activity has been positively correlated with the antioxidant potential in many studies and generally, the oxidative mechanisms are involved in carcinogenesis (Roleira et al, 2015). Our results indicate the possible relationship between antioxidants, inflammation and cytotoxicity in tumor cell lines as the M. charantia extracts were active in all assays.…”

Section: Cytotoxic Propertiessupporting

confidence: 66%

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Svobodová

Barros

Calhelha

et al. 2017

Industrial Crops and Products

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a b s t r a c tA wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, ␤-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC 50 = 10-0.625 g/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant.

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Section: Cytotoxic Propertiessupporting

confidence: 66%

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Svobodová

Barros

Calhelha

et al. 2017

Industrial Crops and Products

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“…Another group found in subfractions is benzoic acid derivatives. Benzoic acid derivatives are known to be effective due to their radical scavenging effects, antimutagenic, anticarcinogenic, anti-inflammatory effects have been identified from natural sources [31].…”

Section: Lc/ms-ms Resultsmentioning

confidence: 99%

“…Flavonoid derivatives are known to have antiproliferative effect in various cancer cell lines and to prevent tumor growth with some animal models [31]. In subfractions, puerarin, vitexin and apigenin-6,8-C-pentoside-hexoside and a flavonoid derivative have been identified by interpreting spectra information.…”

Section: Lc/ms-ms Resultsmentioning

confidence: 99%

Activity Guided Fractionation of Arum italicum Miller Tubers and the LC/MS-MS Profiles

Ağalar¹,

Çiftçi²,

Göğer³

et al. 2017

Rec. Nat. Prod.

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Abstract:In this study, the polar extract of Arum italicum Miller tubers was fractionated by 'biological activity guided fractionation' method. MCF-7 (human breast adenocarcinoma) and A549 (non-small lung cancer) cancer cell lines were used to screen cytotoxic activity. Possible antiproliferative and apoptotic effects of each subfraction were evaluated by in vitro. As a result, E2 were cytotoxic against A549 cell lines while E3 and E6 showed good cytotoxic activities against both cancer cell lines. These three subfractions showed apoptotic and antiproliferative effects comparable with positive control. The chemical composition of each subfraction was determined by LC/MS-MS. Hydroxycinnamic acid derivatives, lignans and glycosides, hydroxycinnamic acidspermidine conjugates and oxylipins identified in subfractions were major secondary metabolites.

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“…The most important feature of these compounds is their antibacterial and antioxidant activity [1][2][3][4][5]. Dietary studies have clearly shown a correlation between the content of phenolic compounds in plant foods and a decrease in the incidence of lifestyle diseases [6,7]. From a wide variety of honeys, consumers frequently choose unifloral honeys because their specific medicinal properties are well defined.…”

Section: Introductionmentioning

confidence: 99%

Chemical Profiling of Polyfloral Belgian Honey: Ellagic Acid and Pinocembrin as Antioxidants and Chemical Markers

Jasicka-Misiak

Gruyaert

Poliwoda

et al. 2017

Journal of Chemistry

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Chemical profiling of northern Belgian polyfloral honeys was performed to analyse their phenolic compound content (flavonoids and phenolic acids). First, samples were subjected to a standard analysis of their physicochemical properties, and then, the phenolic fraction was isolated and analysed using a HPLC/PAD method. All of the tested honeys showed a common and specific phenolic profile that could be the basis for the differentiation of polyfloral honeys of the Antwerp region from other polyfloral honeys. Chromatographic data indicated a high content of ellagic acid (9.13-13.66 mg/100 g honey), as well as the flavonoid pinocembrin (1.60-1.85 mg/100 g honey) in these honeys. Ellagic acid, a compound with well-defined prohealth activities, might be used as a chemical marker for these honeys. With respect to total phenolic and flavonoid contents, 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays were determined spectrophotometrically. The honey exhibited a moderate antioxidant activity, typical for light honeys.

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Plant derived and dietary phenolic antioxidants: Anticancer properties

Cited by 370 publications

References 83 publications

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Activity Guided Fractionation of Arum italicum Miller Tubers and the LC/MS-MS Profiles

Chemical Profiling of Polyfloral Belgian Honey: Ellagic Acid and Pinocembrin as Antioxidants and Chemical Markers

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