Plant derived estrogens relax rat mesenteric artery in vitro

Nevala, Riikka; Korpela, Riitta; Vapaatalo, Heikki

doi:10.1016/s0024-3205(98)00300-2

Cited by 53 publications

(32 citation statements)

References 15 publications

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“…In the present work, incubation with PCRC inhibited KCl concentration-dependent contractile response in thoracic aortic strips of SHRs. This result is consistent with the effect of 17-β estradiol on a large elastic aorta as in previous report (Li et al, 2002; and is also supported by another study (Nevala et al, 1998). These fi ndings suggest that PCRC may have Ca 2+ antagonistic properties and can inhibit extracellular Ca 2+ infl ux through VDCCs, which are similar to those of 17-β estradiol or resveratrol.…”

Section: Fig 8 Upper: Influence Of Chaps On Pcrc-induced Inhibitionsupporting

confidence: 92%

Inhibitory Effects of Polyphenol-Rich Fraction Extracted from Rubus coreanum M on Thoracic Aortic Contractility of Spontaneously Hypertensive Rats

Lim¹,

Min²,

Woo³

et al. 2011

Biomolecules and Therapeutics

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Abstractprotection as well as inhibitory activities on xanthine oxidase, pancreatin, α-amylase, and angiotensin converting enzyme (Cho, 2005). Recently, it has been demonstrated that polyphenol compounds (PCRC), isolated from Bokboonja liquor, inhibits the CA secretory responses evoked by cholinergic (both muscarinic and nicotinic) stimulation as well as by direct membrane-depolarization from the isolated perfused adrenal gland of the normotensive rats (Kee and Lim, 2007) and spontaneously hypertensive rats (Yu et al., 2009). It seems that this inhibitory effect of PCRC is exerted by inhibiting both the Ca 2+ infl ux into the rat adrenal medullary chromaffi n cells and the uptake of Ca 2+ into the cytoplasmic calcium store partly through the increased NO production due to the activation of nitric oxide synthase (Kee and Lim, 2007;Yu et al., 2009).Generally, the presence of polyphenolic compounds isOriginal Article

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Section: Fig 8 Upper: Influence Of Chaps On Pcrc-induced Inhibitionsupporting

confidence: 92%

Inhibitory Effects of Polyphenol-Rich Fraction Extracted from Rubus coreanum M on Thoracic Aortic Contractility of Spontaneously Hypertensive Rats

Lim¹,

Min²,

Woo³

et al. 2011

Biomolecules and Therapeutics

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“…Nevala et al [23] and Herrera et al [24] have reported that GST ( 6 10 -5 mol/l) relaxed Phe-contracted rat aortic rings. In the present study, we confirmed the vascular relaxant effects of GST using a range of GST concentrations.…”

Section: Discussionmentioning

confidence: 96%

The Role of Peroxisome Proliferator-Activated Receptor-γ and Estrogen Receptors in Genistein-Induced Regulation of Vascular Tone in Female Rat Aortas

Xiang

Lin

et al. 2010

Pharmacology

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Background: Genistein (GST) is a phytoestrogen that binds estrogen receptors (ER) to produce a protective cardiovascular effect. It also has been shown binding peroxisome proliferator-activated receptor-γ (PPAR-γ). Methods: In the present study, we assessed the role of PPAR-γ and ER in GST-mediated regulation of vascular tone in female rat aortas by in vitro tension measurement, immunohistochemistry, immunofluorescence, immunoprecipitation and Western blot analysis. Results: In aortas pretreated with GW9662 (inhibitor of PPAR-γ), ICI182780 (inhibitor of ER) and a combination of GW9662 and ICI182780, the magnitudes of GST-induced dilatation were attenuated. N(G)-nitro-L-arginine methyl ester had a similar effect. ER-β and PPAR-γ colocalized in all 3 layers of the aortas, while ER-α and PPAR-γ colocalized only in the vascular endothelium and adventitia. In GST-treated whole-cell protein samples, we demonstrated coimmunoprecipitation of ER-β (not ER-α) and PPAR-γ. The expression of ER-β and PPAR-γ in nuclear protein from GST-treated samples increased, which was partially reversed by either GW9662 or ICI182780 and more efficiently reversed using a combination of GW9662 and ICI182780. Conclusion: Our findings suggest that GST can relax phenylephrine-induced vascular contraction in female rat aortas, which is mediated by PPAR-γ and ER-β.

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“…Wu et al (2010) determined that formononetin, identified to have a similar magnitude of vasorelaxation as biochanin A, may possess a nitric-oxidedependent and endothelium-independent relaxation effect on vasculature unrelated to progesterone or estrogen receptor activation. It has been reported that when exposed to isoflavones, the vasculature will relax (Nevala et al 1998;Simoncini et al 2005), whereas when ergovaline from tall fescue is consumed vasculature will constrict due to binding on amide receptors (Rhodes et al 1991;Aiken et al 2001). Due to the isoflavones found in red clover, it has been suggested that red clover may contribute to an antimicrobial effect within ruminal bacteria communities (Flythe and Kagan 2010) and reduce production of ammonia from ruminal bacteria at a concentration of 30 ppm (Flythe et al 2013).…”

Section: Isoflavonesmentioning

confidence: 99%

Fescue toxicosis and its influence on the rumen microbiome: mitigation of production losses through clover isoflavones

Melchior

Myer

2018

Journal of Applied Animal Research

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This review highlights concerns with endophyte-infected tall fescue as a primary forage base in the southeastern United States and discusses specific physiological and ruminal effects caused by consumption of ergot alkaloids. Additionally, in an effort to promote various mitigation strategies to abate production limitations caused by fescue toxicosis, this review discusses the use of cool-season legumes, specifically red clover, with the already established forage base. Clovers are often mixed into pastures and help improve animal performance. Clovers contain phytoestrogenic compounds known as isoflavones that may be beneficial in reducing physiological limitations with consumption of endophyte-infected tall fescue. ARTICLE HISTORY

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Plant derived estrogens relax rat mesenteric artery in vitro

Cited by 53 publications

References 15 publications

Inhibitory Effects of Polyphenol-Rich Fraction Extracted from Rubus coreanum M on Thoracic Aortic Contractility of Spontaneously Hypertensive Rats

Inhibitory Effects of Polyphenol-Rich Fraction Extracted from Rubus coreanum M on Thoracic Aortic Contractility of Spontaneously Hypertensive Rats

The Role of Peroxisome Proliferator-Activated Receptor-γ and Estrogen Receptors in Genistein-Induced Regulation of Vascular Tone in Female Rat Aortas

Fescue toxicosis and its influence on the rumen microbiome: mitigation of production losses through clover isoflavones

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