Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment

Yi, Chun; Lu, Linzhu; Li, Zhaosheng; Guo, Qianqian; Ou, Longyun; Wang, Ruoyu; Tian, Xuefei

doi:10.1007/s13346-024-01621-x

Drug Deliv. and Transl. Res.

2024

DOI: 10.1007/s13346-024-01621-x

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Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment

Chun Yi,

Linzhu Lu,

Zhaosheng Li

et al.

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2024

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Cited by 3 publications

References 150 publications

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Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance

Yang,

Cui,

Sun

et al. 2024

Cell Commun Signal

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Anti-programmed death 1/programmed death ligand 1 (anti-PD-1/PD-L1) antibodies exert significant antitumor effects by overcoming tumor cell immune evasion and reversing T-cell exhaustion. However, the emergence of drug resistance causes most patients to respond poorly to these immune checkpoint inhibitors (ICIs). Studies have shown that insufficient T-cell infiltration, lack of PD-1 expression, deficient interferon signaling, loss of tumor antigen presentation, and abnormal lipid metabolism are all considered to be closely associated with immunotherapy resistance. To address drug resistance in tumor immunotherapy, a lot of research has concentrated on developing combination therapy strategies. Currently, ICIs such as anti-PD-1 /PD-L1 antibody combined with chemotherapy and targeted therapy have been approved for clinical treatment. In this review, we analyze the mechanisms of resistance to anti-PD-1/PD-L1 therapy in terms of the tumor microenvironment, gut microbiota, epigenetic regulation, and co-inhibitory immune checkpoint receptors. We also discuss various promising combination therapeutic strategies to address resistance to anti-PD-1/PD-L1 drugs, including combining these therapies with traditional Chinese medicine, non-coding RNAs, targeted therapy, other ICIs, and personalized cancer vaccines. Moreover, we focus on biomarkers that predict resistance to anti-PD-1/PD-L1 therapy as well as combination therapy efficacy. Finally, we suggest ways to further expand the application of immunotherapy through personalized combination strategies using biomarker systems.

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Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance

Yang,

Cui,

Sun

et al. 2024

Cell Commun Signal

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Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma

Wang,

Zhang,

Kong

et al. 2024

IJN

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Osteosarcoma is the predominant primary malignant bone tumor that poses a significant global health challenge. MicroRNAs (miRNAs) that regulate gene expression are associated with osteosarcoma pathogenesis. Thus, miRNAs are potential therapeutic targets for osteosarcoma. Nanoparticles, widely used for targeted drug delivery, facilitate miRNA-based osteosarcoma treatment. Numerous studies have focused on miRNA delivery using nanoparticles to inhibit the progress of osteosarcoma. Polymer-based, lipid-based, inorganic-based nanoparticles and extracellular vesicles were used to deliver miRNAs for the treatment of osteosarcoma. They can be modified to enhance drug loading and delivery capabilities. Also, miRNA delivery was combined with traditional therapies, for example chemotherapy, to treat osteosarcoma. Consequently, miRNA delivery offers promising therapeutic avenues for osteosarcoma, providing renewed hope for patients. This review emphasizes the studies utilizing nanoparticles for miRNA delivery in osteosarcoma treatment, then introduced and summarized the nanoparticles in detail. And it also discusses the prospects for clinical applications.

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Exosome-Integrated Hydrogels for Bone Tissue Engineering

Hwang,

Lee

2024

Gels

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Exosome-integrated hydrogels represent a promising frontier in bone tissue engineering, leveraging the unique biological properties of exosomes to enhance the regenerative capabilities of hydrogels. Exosomes, as naturally occurring extracellular vesicles, carry a diverse array of bioactive molecules that play critical roles in intercellular communication and tissue regeneration. When combined with hydrogels, these exosomes can be spatiotemporally delivered to target sites, offering a controlled and sustained release of therapeutic agents. This review aims to provide a comprehensive overview of the recent advancements in the development, engineering, and application of exosome-integrated hydrogels for bone tissue engineering, highlighting their potential to overcome current challenges in tissue regeneration. Furthermore, the review explores the mechanistic pathways by which exosomes embedded within hydrogels facilitate bone repair, encompassing the regulation of inflammatory pathways, enhancement of angiogenic processes, and induction of osteogenic differentiation. Finally, the review addresses the existing challenges, such as scalability, reproducibility, and regulatory considerations, while also suggesting future directions for research in this rapidly evolving field. Thus, we hope this review contributes to advancing the development of next-generation biomaterials that synergistically integrate exosome and hydrogel technologies, thereby enhancing the efficacy of bone tissue regeneration.

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Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment

Cited by 3 publications

References 150 publications

Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance

Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance

Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma

Exosome-Integrated Hydrogels for Bone Tissue Engineering

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