Plant-Derived Medicines with Potential Use in Wound Treatment

Maver, Tina; Kurečič, Manja; Smrke, Dragica; Stana‐Kleinschek, Karin; Maver, Uroš

doi:10.5772/intechopen.72813

Cited by 29 publications

(26 citation statements)

References 119 publications

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“…1,[12][13][14]17 Many plants and various preparations thereof have been used traditionally concerning wound treatment, especially due to their immense potential to affect the wound healing process. 18 To mention some, Vernonia amygdalina Del, 19 Brucea antidysenterica J.F.Mill, 20 Achyranthes aspera, 21 Croton macrostachyus, 22 Datura stramonium, 23 Bersama abyssinica, 24 Rumexa byssinicus, 1 Cordial africana, 25 Aloe spp, 26 and many others.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Lambebo¹,

Kifle²,

Gurji³

et al. 2021

JEP

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Background Medicinal plants play an important role in treating various diseases. Vernonia auriculifera Hiern is one of the medicinal plants used traditionally for the management of wounds. However, there were no scientific reports documented so far on the wound healing activities to substantiate the claim. Thus, the present study provides a scientific evaluation for the wound healing potential of the crude extract as well as solvent fractions of the leaves of Vernonia auriculifera Hiern. Methods Extraction was carried out by maceration using 80% methanol and part of the crude extract fractionated with chloroform, ethyl acetate, and aqueous solvents. Simple ointment bases were prepared using hard paraffin, cetostearyl alcohol, white soft paraffin and wool fat according to British Pharmacopoeia. Then, two types of ointment formulations were prepared from the extract, ie, 5% w/w and 10% w/w. Mice and rats were employed for wound healing study and dermal toxicity test, respectively. Wound healing effects were evaluated by percent of wound contraction, period of epithelialization, tensile strength, and histological analysis as parameters in excision, incision, and burn wound models. Finally, the data were expressed as mean ± SEM, and the results were analyzed using one-way ANOVA followed by post hoc Tukey-test. Results In the excision wound model, the 10% w/w crude extract ointment showed significant wound contraction ( P < 0.001) from day 4 to day 18 as compared to the negative control. Both the 5% w/w ( P < 0.001) and 10% w/w ( P < 0.05) crude extract ointments have showed statistically significant difference in epithelialization period as compared to the negative control. Groups treated with the ethyl acetate and aqueous fractions ointments in incision wound model showed a statistically significant ( P < 0.001) increase in tensile. The 10% w/w and 5% w/w ointments of the crude extract showed a significant ( P < 0.001) increase in breaking strength compared to simple ointment and the untreated control groups. In burn wound model, significant reduction in epithelialization period was observed in 5% w/w ( P < 0.05) and 10% w/w ( P < 0.001), and the percentage of wound contraction was significantly increased in most of post wounding days by 10% w/w ( P < 0.001) and 5% w/w ( P < 0.05) crude extract ointments and compared to the negative control. Conclusion The crude, aqueous, and ethyl acetate fraction of Vernonia auriculifera leaves possess wound healing activities. This finding justifies the use of the leaves of this plant for wound healing as claimed in the traditional medicine literature.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Lambebo¹,

Kifle²,

Gurji³

et al. 2021

JEP

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“…The structural diversity of diterpenes enables a wide array of biological activities, including antioxidant, anti-inflammatory, antimicrobial, wound-healing, antihypertensive, analgesic, neuropharmacological, and antineoplastic activities. [122][123][124] Diterpenoids are significant components of E. fischeriana Steud. and exhibit various pharmacological properties, such as antiviral, immune-enhancing, sedative, analgesic, and anticancer.…”

Section: Diterpene Biological Activitymentioning

confidence: 99%

The Role of Ingenane Diterpenes in Cancer Therapy: From Bioactive Secondary Compounds to Small Molecules

Silva

Faleiros

Silva

et al. 2022

Natural Product Communications

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Diterpenes are a class of critical taxonomic markers of the Euphorbiaceae family, representing small compounds (eg, molecules) with a wide range of biological activities and multi-target therapeutic potential. Diterpenes can exert different activities, including antitumor and multi-drug resistance-reversing activities, and antiviral, immunomodulatory, and anti-inflammatory effects, mainly due to their great structural diversity. In particular, one polycyclic skeleton has been highlighted: ingenane. Besides this natural diterpene, promising polycyclic skeletons may be submitted to chemical modification—by in silico approaches, chemical reactions, or biotransformation—putatively providing more active analogs (eg, ingenol derivatives), which are currently under pre-clinical investigation. This review outlines the current mechanisms of action and potential therapeutic implications of ingenol diterpenes as small cancer molecules.

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“…Regarding antimicrobial action, promising compounds extracted from plants include alkaloids, polyphenols, saponins, tannins, terpenoids, glucosinolates and sulfides [ 91 , 92 ]. Moreover, lectins, together with polyacetylenes, can have the same antimicrobial activity as the aforementioned substances [ 93 ].…”

Section: Alternatives To Conventional Antibiotics Used To Treat Bacterial Skin Infections In Animalsmentioning

confidence: 99%

Bacterial Skin Infections in Livestock and Plant-Based Alternatives to Their Antibiotic Treatment

Malá

Laloučková

Skřivanová

2021

Animals

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Due to its large surface area, the skin is susceptible to various injuries, possibly accompanied by the entrance of infective agents into the body. Commensal organisms that constitute the skin microbiota play important roles in the orchestration of cutaneous homeostasis and immune competence. The opportunistic pathogen Staphylococcus aureus is present as part of the normal biota of the skin and mucous membranes in both humans and animals, but can cause disease when it invades the body either due to trauma or because of the impaired immune response of the host. Colonization of livestock skin by S. aureus is a precursor for majority of bacterial skin infections, which range from boils to sepsis, with the best-characterized being bovine mastitis. Antibiotic treatment of these infections can contribute to the promotion of resistant bacterial strains and even to multidrug resistance. The development of antibiotic resistance to currently available antibiotics is a worldwide problem. Considering the increasing ability of bacteria to effectively resist antibacterial agents, it is important to reduce the livestock consumption of antibiotics to preserve antibiotic effectiveness in the future. Plants are recognized as sources of various bioactive substances, including antibacterial activity towards clinically important microorganisms. This review provides an overview of the current knowledge on the major groups of phytochemicals with antibacterial activity and their modes of action. It also provides a list of currently known and used plant species aimed at treating or preventing bacterial skin infections in livestock.

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Plant-Derived Medicines with Potential Use in Wound Treatment

Cited by 29 publications

References 119 publications

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

The Role of Ingenane Diterpenes in Cancer Therapy: From Bioactive Secondary Compounds to Small Molecules

Bacterial Skin Infections in Livestock and Plant-Based Alternatives to Their Antibiotic Treatment

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