Plant-derived polyphenols in sow nutrition: An update

Micro-environment triple-responsive hyaluronic acid hydrogel dressings to promote antibacterial activity, collagen deposition, and angiogenesis for diabetic wound healing

“…TA captures and stabilizes the free radicals. 53 Moreover, TA diffuses into cells and reduces intracellular ROS. This was evaluated using an in situ formed ROS probe inside the cell.…”

Effects of a Phytogenic Feed Additive on Redox Status, Blood Haematology, and Piglet Mortality in Primiparous Sows

“…PFAs are based on plants that are rich in antioxidants, and among them, polyphenol is the most common substance [2,46]. Plant-derived polyphenols have beneficial effects for gestating and lactating sows, as they can beneficially regulate the placenta and mammary glands of sows, thus resulting in better growth, development, and physiological functions of offspring piglets [47]. The tested commercial PFA in our study contains 60% pure herbal compounds with a specific high natural content of polyphenols (>6.0%), which may explain its high antioxidant properties in sows.…”

“…PFA is based on plants that are rich in antioxidants, including phenols, flavonoids, flavanols, vitamins C and E, betacarotene, zinc, and selenium, which have been shown to have antioxidant potential [45]. Polyphenols are the most common substance [14,46] with beneficial effects for gestating and lactating sows, as they can beneficially regulate the placenta and mammary glands of sows, thus resulting in improved growth performance of offspring piglets [47]. Even if the beneficial effects of PFA administration in pigs have been previously reported, the study of their effect on stress in farrowing sows is limited [2,48].…”

Plant-Derived Polyphenols as Nrf2 Activators to Counteract Oxidative Stress and Intestinal Toxicity Induced by Deoxynivalenol in Swine: An Emerging Research Direction

“…Oxidative stress is a phenomenon in which the overproduction of ROS exceeds the ROS-scavenging ability or antioxidant capacity of cells [ 18 ]. In both in vivo and in vitro porcine studies, DON exposure has been demonstrated to generate free radicals, including ROSs that induce intestinal oxidative damage, which results in alterations in membrane integrity, cellular redox signaling, and changes in the antioxidant status of the intestinal cells [ 9 , 17 , 27 , 28 ]. Normally, DON exposure compromises the physiological functions of mitochondria and results in the overproduction of free radicals (including ROS), which further induce oxidative damage, including lipid peroxidation, DNA injury, and protein oxidation [ 18 ].…”

“…In this regard, antioxidants should be the best candidates to counteract oxidative stress and gut toxicity caused by DON-contaminated feed. Polyphenols are a large group of plant secondary metabolites with strong antioxidant abilities, which is attributed to their special chemical structure (aromatic rings with multiple hydrogen hydroxyl groups) [ 27 ]. Recently, increasing attention has been focused on polyphenols to detoxify gut toxicity by DON exposure [ 10 , 29 , 31 , 32 , 33 ].…”