Plant‐Derived Products for Treatment of Vascular Intima Hyperplasia Selectively Inhibit Vascular Smooth Muscle Cell Functions

Xu, Kang; Al-ani, Mohanad Kh; Pan, Xuran; Chi, Qingjia; Dong, Nianguo; Qiu, Xuefeng

doi:10.1155/2018/3549312

Cited by 21 publications

(12 citation statements)

References 123 publications

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“…Some natural compounds have been verified to have inhibitory effects on the abnormal proliferation and migration of VSMCs, including polyphenols, flavonoids, terpenes, and alkaloids [ 40 ]. In the treatment of cardiovascular diseases, research on flavonoids and polyphenols has mainly focused on reducing the risk of hypertension, atherosclerosis, vascular inflammation, and oxidative stress, as well as the impact on related signaling pathways [ 40 , 41 , 42 ]. The flavonoid compounds of CGA, lut, and lut-7-g have been reported as the main active compounds of GT [ 20 , 21 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells

Hsuan

Tsai

et al. 2020

Molecules

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The proliferation and migration of vascular smooth muscle cells (VSMCs) are essential in the pathogenesis of various vascular diseases, such as atherosclerosis and restenosis. Among the mediators of VSMC during atherosclerosis development, platelet-derived growth factor (PDGF)-BB is a potent mitogen for VSMCs and greatly contributes to the intimal accumulation of VSMCs. Glossogyne tenuifolia (GT, Xiang-Ru) is a traditional antipyretic and hepatoprotective herb from Penghu Island, Taiwan. This study evaluated the inhibitory effect of GT ethanol extract (GTE) and GT water extract (GTW) on proliferative and migratory activities in PDGF-BB-induced VSMCs. The experimental results demonstrated that GTE significantly inhibited the PDGF-BB-stimulated VSMC proliferation and migration, as shown by MTT, wound healing, and Boyden chamber assays. GTE was found to have a much more potent inhibitory activity than GTW. Based on the Western blot analysis, GTE significantly blocked the PDGF-BB-induced phosphorylation of NF-κB and mitogen-activated protein kinase (MAPK) pathways, including extracellular signal-regulated kinase (ERK), p38, and JNK, in VSMCs. In addition, GTE retarded the PDGF-BB-mediated migration through the suppression of matrix metalloproteinase (MMP)-2 and MMP-9 expression in VSMCs. Three main ingredients of GT—chlorogenic acid, luteolin-7-glucoside, and luteolin—all showed significant anti-proliferative effects on PDGF-BB-induced VSMCs. As a whole, our findings indicated that GTE has the potential to be a therapeutic agent to prevent or treat restenosis or atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells

Hsuan

Tsai

et al. 2020

Molecules

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“…Various herbal plant-based components were studied for their cardiovascular protection effect (Barnard et al, 2019;Kim et al, 2019;Tuso et al, 2015). Xu et al compiled a list of natural plant derived compounds such as flavonoids, polyphenols, alkaloids, and terpenes that were found to efficiently suppress VSMCs migration and proliferation (Xu et al, 2018). They further elucidated the involvement of typical cell regulatory and inflammatory pathways including MAPKs, PI3K/Akt, JAK-STAT, FAK, and NF-κB in VSMCs migration.…”

Section: Plant-based Approach For Ihmentioning

confidence: 99%

“…HT is a well-studied phytochemical for its vascular protection (Hernáez et al, 2017;Nemzer et al, 2019), antioxidant (Adawiyah Razali et al, 2019Soler-Cantero et al, 2012;Tejada et al, 2016), anti-inflammatory (Chin and Pang, 2017;Ng et al, 2017;Vilaplana-Pérez et al, 2014;Li et al, 2017), anti-atherogenic properties including the inhibition of LDL oxidation (Storniolo et al, 2019); and anti-platelet aggregation (De Roos et al, 2011). A couple of independent research elucidated HT potential in the attenuation of IH development (Xu et al, 2018;Man et al, 2020) However, HT has not been employed in any in vivo model to treat IH. Therefore, we aim to collect the scientific evidence of HT in the suppression of IH.…”

Section: Plant-based Approach For Ihmentioning

confidence: 99%

Molecular Action of Hydroxytyrosol in Attenuation of Intimal Hyperplasia: A Scoping Review

et al. 2021

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Objective: Hydroxytyrosol (HT), a polyphenol of olive plant is well known for its antioxidant, anti-inflammatory and anti-atherogenic properties. The aim of this systematic search is to highlight the scientific evidence evaluating molecular efficiency of HT in halting the progression of intimal hyperplasia (IH), which is a clinical condition arises from endothelial inflammation.Methods: A systematic search was performed through PubMed, Web of Science and Scopus, based on pre-set keywords which are Hydroxytyrosol OR 3,4-dihydroxyphenylethanol, AND Intimal hyperplasia OR Neointimal hyperplasia OR Endothelial OR Smooth muscles. Eighteen in vitro and three in vitro and in vivo studies were selected based on a pre-set inclusion and exclusion criteria.Results: Based on evidence gathered, HT was found to upregulate PI3K/AKT/mTOR pathways and supresses inflammatory factors and mediators such as IL-1β, IL-6, E-selectin, P-selectin, VCAM-1, and ICAM-1 in endothelial vascularization and functioning. Two studies revealed HT disrupted vascular smooth muscle cells (SMC) cell cycle by dephosphorylating ERK1/2 and AKT pathways. Therefore, HT was proven to promote endothelization and inhibit vascular SMCs migration thus hampering IH development. However, none of these studies described the effect of HT collectively in both vascular endothelial cells (EC) and SMCs in IH ex vivo model.Conclusions: Evidence from this concise review provides an insight on HT regulation of molecular pathways in reendothelization and inhibition of VSMCs migration. Henceforth, we propose effect of HT on IH prevention could be further elucidated through in vivo and ex vivo model.

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“…Current guidelines also recommend the use of lipid-lowering drugs, including statins (Okopień et al, 2016), to treat restenosis, but they all have varying degrees of side effects, such as gastrointestinal reaction, liver function damage, and rhabdomyolysis. Recently, natural products have been widely used to prevent intimal hyperplasia in common cardiovascular diseases (Xu et al, 2018). Propolis is a kind of resinous substance produced by worker bees of Apis mellifera, it is formed by combining the secretions of propolis source plants and resins with the secretions of mandibular glands and wax glands.…”

Section: Introductionmentioning

confidence: 99%

Propolis ameliorates restenosis in hypercholesterolemia rabbits with carotid balloon injury by inhibiting lipid accumulation, oxidative stress, and TLR4/NF‐κB pathway

Ji¹,

Pan

et al. 2021

J. Food Biochem.

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Neointima formation and atherosclerosis are the main complications after the endovascular intervention and vascular surgery, and there are no effective drugs.Propolis is a kind of resin substance produced by honeybees and has numerous health-beneficial effects. In this study, we evaluated the effects of propolis (125 and 250 mg•kg -1 •day -1 , 6 weeks) on carotid restenosis in hypercholesterolemia rabbits.Propolis significantly ameliorated the degree of carotid restenosis, inhibited neointima hyperplasia, reduced serum lipids profile, and enhanced the anti-oxidative activities in hypercholesterolemia rabbits. Furthermore, propolis reduced the plasma levels of C-reactive protein, interleukin-6, and tumor necrosis factorα (TNFα), and inhibited the expression of CD68, TLR4, NF-κB p65, MMP-9, and TNFα in the carotid arteries. The results indicate that propolis has a protective effect on carotid restenosis in rabbits, which is associated with regulating blood lipids, inhibiting oxidative stress and inflammation, and its anti-inflammatory activity may be related to inhibit TLR4-mediated NF-κB signaling pathway. Practical applicationsRestenosis is a primary challenge in angioplasty and atherosclerotic treatment.Hyperlipidemia can induce inflammation and accelerate the formation of restenosis.Recently, natural products have been widely used to prevent intimal hyperplasia of common cardiovascular diseases. Propolis is currently a popular functional food, but the role of propolis on carotid restenosis after angioplasty and its underlying mechanism remains unclear. This study showed that propolis inhibits the effect of carotid restenosis in hypercholesterolemia rabbits. The results of this study may provide a basis for propolis to prevent and treat vascular restenosis.

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Plant‐Derived Products for Treatment of Vascular Intima Hyperplasia Selectively Inhibit Vascular Smooth Muscle Cell Functions

Cited by 21 publications

References 123 publications

Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells

Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells

Molecular Action of Hydroxytyrosol in Attenuation of Intimal Hyperplasia: A Scoping Review

Propolis ameliorates restenosis in hypercholesterolemia rabbits with carotid balloon injury by inhibiting lipid accumulation, oxidative stress, and TLR4/NF‐κB pathway

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