Plant-derived selenium nanoparticles: investigating unique morphologies, enhancing therapeutic uses, and leading the way in tailored medical treatments

Puri, Abhijeet; Mohite, Popat; Ansari, Yunus; Mukerjee, Nobendu; Alharbi, Hanan M.; Upaganlawar, Aman; Thorat, Nanasaheb

doi:10.1039/d3ma01126g

Cited by 8 publications

References 133 publications

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Theranostic scope of monometallic selenium and titanium dioxide nanoparticles in biomedicine: A review

Nagarajan,

Jayaraman,

Ramakrishnan

2024

Health Care Science

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The nanoparticles (NPs) of metals and metal oxides constitute significant components of technology in terms of monometallic NPs (MNPs). Over the last decade, the most fascinating and in‐depth uses of NPs have been found in the biomedical field, which has demonstrated the therapeutic potential of these particles. Significant strides have been made in the application of nanotechnology across various industries, including biomedical sciences. In biomedicine, two of the most important applications of NPs are in the diagnosis and treatment of disease. Given their ability to deliver specific drugs, these next‐generation NPs provide safe and effective pharmacotherapies for a wide range of disorders. Selenium nanoparticles (SeNPs) and titanium dioxide (TiO2) NPs offer potential treatments for various applications, including hair care and cancer treatment. SeNPs help with abiotic stress, plant disease, and growth, while TiO2 NPs enhance bio‐imaging and drug delivery. This comprehensive review focuses on MNPs like Se (metal‐based) and TiO2 (metal‐oxide based). It covers their synthesis methods, nanoscale physicochemical properties, and the definition of specific industrial applications in various fields of applied nanotechnology, including biomedicine.

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Theranostic scope of monometallic selenium and titanium dioxide nanoparticles in biomedicine: A review

Nagarajan,

Jayaraman,

Ramakrishnan

2024

Health Care Science

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Green Synthesis of Selenium Nanoparticles Utilizing Drimia indica: Insights Into Anticancer and Antimicrobial Activities

Ameen,

Almalki,

Alshalan

et al. 2024

Microscopy Res & Technique

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Selenium nanoparticles (SeNPs) have garnered significant interest as anticancer and antimicrobial agents. The aqueous extract of medicinal plant Drimia indica leaves (DI‐LAE) was used to synthesize SeNPs (DI‐SeNPs) that were extensively characterized by UV–visible absorbance, TEM, EDX, XRD, zeta potential measurements, and FTIR. DI‐SeNPs exhibited dose‐dependent toxicity against the human lung adenocarcinoma cell line (A549; IC50 of 43.21 μg/mL). DI‐SeNPs increased reactive oxygen species (ROS) generation in A549 cells. DI‐SeNPs caused cell cycle arrest in the G2/M phase and increased DNA damage in A549 cells, ultimately driving these cells toward apoptosis. DI‐SeNPs significantly increased p53 levels, decreasing Akt levels and elevating cleaved caspase 3 levels in A549 cells. Additionally, DI‐SeNPs exhibited antimicrobial activity against various bacteria and fungi. These findings suggest that DI‐SeNPs possess significant anticancer and antimicrobial properties, mediated through mechanisms involving ROS generation, cell cycle arrest, and apoptosis induction.

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Journey Through Nanometals: From the Synthesis Lab to Utilization

Sharon,

Höfer

2024

Reference Module in Materials Science and Materials Engineering

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Plant-derived selenium nanoparticles: investigating unique morphologies, enhancing therapeutic uses, and leading the way in tailored medical treatments

Abstract: Selenium (Se) stands as a paramount micronutrient, indispensable for the holistic health of humans, animals, and microorganisms. At its core, Se is instrumental for the genesis of selenocysteine, an exclusive...

Cited by 8 publications

References 133 publications

Theranostic scope of monometallic selenium and titanium dioxide nanoparticles in biomedicine: A review

Theranostic scope of monometallic selenium and titanium dioxide nanoparticles in biomedicine: A review

Green Synthesis of Selenium Nanoparticles Utilizing Drimia indica: Insights Into Anticancer and Antimicrobial Activities

Journey Through Nanometals: From the Synthesis Lab to Utilization

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