Plant Extracts Antiviral Activity against Herpes simplex Virus Type 1 and African Swine Fever Virus

Silva, Olga; Barbosa, Sheyla Fernanda da Costa; Diniz, Ana Rita; Valdeira, Maria Luísa; Gomes, Eduardo

doi:10.1076/phbi.35.1.12.13264

Cited by 59 publications

(49 citation statements)

References 7 publications

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“…The aerial have virucidal activity against a clinical strain of Herpes simplex virus type I (SHV-1) and African swine fever virus (ASFV) (Silva et al, 1997). The leaves and the roots have a purgative effect attributed to their content of anthraquinones.…”

Section: Biological Activity and Toxicologymentioning

confidence: 99%

A survey of toxic plants on the market in the district of Bamako, Mali: traditional knowledge compared with a literature search of modern pharmacology and toxicology

Maiga

Diallo

Seydou

et al. 2005

Journal of Ethnopharmacology

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Section: Biological Activity and Toxicologymentioning

confidence: 99%

A survey of toxic plants on the market in the district of Bamako, Mali: traditional knowledge compared with a literature search of modern pharmacology and toxicology

Maiga

Diallo

Seydou

et al. 2005

Journal of Ethnopharmacology

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“…The method described by Silva et al (1997) was used where, a 6-well plate was cultivated with Vero cell (HSV) and another plate containing HepG2 (HAV) culture (10 5 cell/ml) and incubated for 2 days at 37°C. Virus was diluted to give 10 7 PFU/ml as final concentrations and mixed with the algal extract at the previous concentration and incubated overnight at 4°C.…”

Section: Plaque Infectivity Reduction Assaymentioning

confidence: 99%

Salt stress enhancement of antioxidant and antiviral efficiency of Spirulina platensis

Shalaby¹,

Shanab²,

Singh³

2010

J. Med. Plants Res.

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Cultivation of Spirulina platensis under salt stress conditions (0.02 M as control), 0.04 and 0.08 M NaCl led to a remarkable alteration of algal metabolism as well as an enhancement or induction of biologically active compounds. Concerning algal growth, salt stress caused a decrease in dry weight, chlorophyll a content as well as certain xanthophylls (neoxanthin and violaxanthin) while β-carotene production was stimulated especially at higher salt concentrations. Biochemical analysis of salt stressed algal revealed that lipid content was slightly increased together with certain saturated and unsaturated fatty acids especially the polyunsaturated ones (γ-inolenic acid, omega 3 fatty acid). Electrophoretic analysis of soluble protein pointed out that certain high molecular weight protein bands were not detected comparing with the protein marker. Five new protein bands of molecular weights 190, 158, 113, 77 and 28 KDa were recorded, in addition to an increase in the intensity of 6 already existing bands. Phosphate buffer and water extracts of the algal exhibited antiviral activities against both Hepatitis-A-virus-type-MBB (HAV-MBB strain, RNA virus) and Herpes simplex-virus-type-1 (HSV-1, DNA virus). Water extracts were found to be more effective than phosphate buffer extracts in inducing antiviral activities (98%) especially against HSV-1 virus. The same water extract of the salt stressed algal demonstrated higher anticoagulating activity compared with those of heparin and the positive control measured by clotting time assay. Antioxidant activity of the algal successive extracts against 2, 2 diphenyl-1-picrylhydrazyl and 2,2'-azino-bis (ethylbenzthiazoline-6-sulfonic acid) radical methods revealed moderate antioxidant activity of the non-polar algal extracts (petroleum ether) which were doubled with increasing extract concentration. The lowest activity was recorded by the partially polar (ethyl acetate) algal extract of both concentrations at all salinity levels. While the polar extracts (ethanol and water) showed higher antioxidant activities which were doubled with increasing extract concentration. Ethanolic algal extract (100 µg/ ml at 0.08 M NaCl) exhibited the highest antioxidant activity compared with those of the synthetic antioxidant butylated hydroxy anisol as standard (85.0, 89.9 and 86.0, 91.8% respectively).Key words: Spirulina platensis, antioxidant-antivirus, biochemical studies, salt stress. INTRODUCTIONMany cyanobacteria and micro algae were considered as a natural source of various biologically and pharmacologically active compounds with structurally complex molecules which are difficult or impossible to be *Corresponding author. E-mail: dremad2009@yahoo.com.produced by chemical synthesis (Smith and Doan, 1999). Genus Spirulina has gained an importance and international demand for its high phytonutrients value and pigments which have applications in healthy foods, animal feed, therapeutics and diagnostics (Becker, 1994;Vonshak and Tomaselli, 2000). Spirulina has been used as food and nutritional ...

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“…All the prepared compounds were submitted to test for antiviral activity against HBV (hepatitis B viruses). The test was carried out according to the method [22].…”

Section: -(4-(2-oxoindolin-3-ylideneamino)arylsulfonyl)isoindoline-1mentioning

confidence: 99%

Synthesis, antiviral and antimicrobial screening of some new 2-oxoindoline derivatives

Farghaly

Abdel‐Wahab

Ahmed

2009

Chem Heterocycl Comp

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Plant Extracts Antiviral Activity against Herpes simplex Virus Type 1 and African Swine Fever Virus

Cited by 59 publications

References 7 publications

A survey of toxic plants on the market in the district of Bamako, Mali: traditional knowledge compared with a literature search of modern pharmacology and toxicology

A survey of toxic plants on the market in the district of Bamako, Mali: traditional knowledge compared with a literature search of modern pharmacology and toxicology

Salt stress enhancement of antioxidant and antiviral efficiency of Spirulina platensis

Synthesis, antiviral and antimicrobial screening of some new 2-oxoindoline derivatives

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