Plant Food Residues as a Source of Nutraceuticals and Functional Foods

Varzakas, Theodoros; Zakynthinos, G.; Verpoort, Francis

doi:10.3390/foods5040088

Cited by 160 publications

(106 citation statements)

References 202 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Phenolic compounds (PC) exert several medicinal and health benefits (Varzakas, Zakynthinos, & Verpoort, ). Studies have shown that PC possess physiological properties favoring antidiabetes, vasodilatory, antimicrobial, antithrombotic, antiinflammatory, antihypertensive, and especially antioxidant effects (Conforti et al, ; Dai, Chen, Johnson, Szeto, & Rabinovitch, ; Hanhineva et al, ; Khurana et al, ).…”

Section: Introductionmentioning

confidence: 99%

Long‐term intake of phenolic compounds attenuates age‐related cardiac remodeling

et al. 2019

View full text Add to dashboard Cite

With the onset of advanced age, cardiac‐associated pathologies have increased in prevalence. The hallmarks of cardiac aging include cardiomyocyte senescence, fibroblast proliferation, inflammation, and hypertrophy. The imbalance between levels of reactive oxygen species (ROS) and antioxidant enzymes is greatly enhanced in aging cells, promoting cardiac remodeling. In this work, we studied the long‐term impact of phenolic compounds (PC) on age‐associated cardiac remodeling. Three‐month‐old Wistar rats were treated for 14 months till middle‐age with either 2.5, 5, 10, or 20 mg kg−1 day−1 of PC. PC treatment showed a dose‐dependent preservation of cardiac ejection fraction and fractional shortening as well as decreased hypertrophy reflected by left ventricular chamber diameter and posterior wall thickness as compared to untreated middle‐aged control animals. Analyses of proteins from cardiac tissue showed that PC attenuated several hypertrophic pathways including calcineurin/nuclear factor of activated T cells (NFATc3), calcium/calmodulin‐dependent kinase II (CAMKII), extracellular regulated kinase 1/2 (ERK1/2), and glycogen synthase kinase 3ß (GSK 3ß). PC‐treated groups exhibited reduced plasma inflammatory and fibrotic markers and revealed as well ameliorated extracellular matrix remodeling and interstitial inflammation by a downregulated p38 pathway. Myocardia from PC‐treated middle‐aged rats presented less fibrosis with suppression of profibrotic transforming growth factor‐ß1 (TGF‐ß1) Smad pathway. Additionally, reduction of apoptosis and oxidative damage in the PC‐treated groups was reflected by elevated antioxidant enzymes and reduced RNA/DNA damage markers. Our findings pinpoint that a daily consumption of phenolic compounds could preserve the heart from the detrimental effects of aging storm.

show abstract

Section: Introductionmentioning

confidence: 99%

Long‐term intake of phenolic compounds attenuates age‐related cardiac remodeling

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Consequently, metabolites with biological activities are produced (van Duynhoven and others ). Along with the intensive ongoing researches, the polyphenol‐rich matrices were classified as nutraceutical food, because of their medicinal and health benefits (Varzakas and others ). Structurally, the PC, also known as active molecules, belong to various categories based on the chemical nature of their functional groups (Balasundram and others ).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Long‐Term Intake of Phenolic Compounds‐Rich Grape Pomace on Rat Gut Microbiota

Chacar

Itani

Hajal

et al. 2017

Journal of Food Science

View full text Add to dashboard Cite

The aim of this work is to evaluate the impact on the rat microbiota of long-term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty, 2-mo-old rats, were divided into 5 groups. Four groups were treated with different concentrations of PC (2.5, 5, 10, and 20 mg/kg/d diluted in 0.1% DMSO), and 1 group received 0.1% Dimethyl Sulfoxide (DMSO) alone (control group). The daily treatment lasted 14 mo. Major phenolic compounds constituents were characterized by the high-performance liquid chromatography and free radical scavenging capacity was measured by means of the DPPH assay. Fecal samples from young rats (2-mo old), and rats daily fed with PC or DMSO were collected at 6 and 14 mo posttreatment. The gut microbiota composition was analyzed by quantitative polymerase chain reaction. Bifidobacterium was significantly higher in the groups PC 2.5 and PC 5 than in control and young rats. Lactobacillus decreased with time in all treated and untreated groups. Bacteroides, Clostridium leptum subgroup (Clostridium cluster IV), and Enterococcus were not significantly changed by PC at any concentration when compared to control; nevertheless, after 14 mo of treatment all concentrations of PC abolished the increase of Clostridium sensu stricto (cluster I) (Clostridium Cluster I) observed in the control group when compared to young rats. PC do modulate selectively rat gut microbiome to a healthier phenotype in long-term feeding rats, and could counteract the adverse outcomes of aging on gut bacterial population.Keywords: aging, gut microbiota, phenolic compoundsPractical Application: This research shows that phenolic-rich grape pomace extracts exhibiting a high antioxidant activity, selectively modulate rat gut microbiota to a healthier phenotype within age in a long-term feeding rats.

show abstract

“…Nowadays, many by-products (BP) are transformed into useful ingredients, and some of these ingredients have been commercialized and widely used in food, nutraceutical, cosmetic, and other industries [1]. However, vegetables and some fruits yield between 25% and 30% of nonedible products, and the BP of fruits and vegetables are made up of skins and seeds of di erent shapes and sizes that normally have no further usage and are commonly wasted or discarded [2].…”

Section: Introductionmentioning

confidence: 99%

Sea Buckthorn (Hippophae rhamnoides L.) and Quince (Cydonia oblonga L.) Juices and Their By-Products as Ingredients Showing Antimicrobial and Antioxidant Properties for Chewing Candy: Nutraceutical Formulations

Lėlė

Monstaviciute

Varinauskaite

et al. 2018

Journal of Food Quality

View full text Add to dashboard Cite

Sustainable and environmentally friendly approaches to the production of health foods have become very popular. e concept of this study was to develop chewing candy (CC)-nutraceutical formulations based on sea buckthorn (Hippophae rhamnoides L.) and quince (Cydonia oblonga L.) juice and juice by-products (BuJ, QuJ, BuBP, and QuBP, resp.), as ingredients showing antimicrobial properties against Klebsiella pneumoniae, Salmonella enterica, Pseudomonas aeruginosa, Acinetobacter baumannii, Proteus mirabilis, methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, E. faecium, and Bacillus cereus. Two texture-forming agents (agar and gelatin) were tested for CC formulation. BuJ, QuJ, BuBP, and QuBP showed antimicrobial activity against all the pathogens tested, and the largest inhibition zones against Bacillus and Proteus mirabilis were observed for BuJ and QuJ, respectively. Agar and/or gelatin selection has a signi cant in uence on CC texture (p 0.0001), and interactions of agar and/or gelatin selection × juice or juice by-products and sea buckthorn or quince × juice or juice by-products were also signi cant (p 0.0001). e best acceptability was shown for CC prepared with agar and BuBP (131.7) and with gelatin and QuJ (132.0). e addition of BuJ, QuJ, BuBP, and QuBP increases the antioxidant activity of CC by ve times. Finally, not just juice, but also juice by-products, have great potential as desirable antimicrobial ingredients for the food industry.

show abstract

Plant Food Residues as a Source of Nutraceuticals and Functional Foods

Abstract: This chapter describes the use of different plant and vegetable food residues as nutraceuticals and functional foods. Different nutraceuticals are mentioned and explained. Their uses are well addressed along with their disease management and their action as nutraceutical delivery vehicles.

Cited by 160 publications

References 202 publications

Long‐term intake of phenolic compounds attenuates age‐related cardiac remodeling

Long‐term intake of phenolic compounds attenuates age‐related cardiac remodeling

The Impact of Long‐Term Intake of Phenolic Compounds‐Rich Grape Pomace on Rat Gut Microbiota

Sea Buckthorn (Hippophae rhamnoides L.) and Quince (Cydonia oblonga L.) Juices and Their By-Products as Ingredients Showing Antimicrobial and Antioxidant Properties for Chewing Candy: Nutraceutical Formulations

Contact Info

Product

Resources

About