Plant innate immunity against human bacterial pathogens

Melotto, Maeli; Panchal, Shweta; Roy, Daipayan

doi:10.3389/fmicb.2014.00411

Cited by 52 publications

(53 citation statements)

References 84 publications

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“…A recent study shows that SL1344, like Pst DC3000, causes a transient stomatal closure (Roy et al, 2013). The mechanisms underlying stomatal closure and reopening mediated by SL1344 are not understood, but it appears that not only plant pathogens, but also some human pathogens may have evolved mechanisms to modulate plant stomatal movements as part of their colonization strategy of the phyllosphere (Roy et al, 2013;Melotto et al, 2014). As such, the study of stomatal defense may have implications beyond plant diseases.…”

Section: Unknown Bacterial Factorsmentioning

confidence: 99%

Stomatal Defense a Decade Later

et al. 2017

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Section: Unknown Bacterial Factorsmentioning

confidence: 99%

Stomatal Defense a Decade Later

et al. 2017

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“…SpvC interacts actively with the MPK6 and dephosphorylates this kinase, consequently abolishing the signal transduction [95]. A comprehensive overview of the reports regarding the plant immune responses to HPs was published only recently and is an excellent compendium of the current knowledge [98].…”

Section: The Function Of T3ss and The Role Of Plant Immune System Durmentioning

confidence: 99%

Interaction between Salmonella and Plants: Potential Hosts and Vectors for Human Infection

Fornefeld¹,

Schierstaedt²,

Jechalke³

et al. 2017

Current Topics in Salmonella and Salmonellosis

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Fruits and vegetables are important for a healthy diet. However, when eaten raw and contaminated with human pathogens (HPs) they may cause a disease outbreak. Contamination with HPs can occur along the entire farm-to-fork production chain and Salmonella enterica is one of the most common foodborne pathogens. A range of biotic and abiotic environmental factors can inluence the complex interactions between Salmonella and plants. Moreover, the outcome of experiments largely depends on the experimental design and parameters or methods employed, and on top, on the accompanying plant microbiome and the genetic equipment of the plant and the Salmonella strain. Particularly mobile genetic elements contribute to the diversiication and adaptation of Salmonella to the plant environment. So far, litle is known about the key processes and factors inluencing the atachment and potential internalization of Salmonella in plants and the plant speciic responses. It is therefore important to beter understand the ecology of Salmonella in the soil and plant environment, in order to propose practicable recommendations for prevention of foodborne diseases. This also requires improved sensitivity and speciicity of detection methods. In this chapter, we present the current knowledge, research needs, and methodology regarding the complex interactions between Salmonella and plants.

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“…Endophytic survival of bacterial pathogens of humans seems to be regulated by the plant immune system reviewed by [32][33][34]. Microbe-associated molecular patterns (MAMPs), such as the motor protein flagellin in bacteria [35], can induce plant basal defenses known as MAMP-Triggered Immunity (MTI) [36].…”

Section: Introductionmentioning

confidence: 99%

Novel molecular components involved in callose-mediated Arabidopsis defense against Salmonella enterica and Escherichia coli O157:H7

2020

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Background: Food contamination with Salmonella enterica and enterohemorrhagic Escherichia coli is among the leading causes of foodborne illnesses worldwide and crop plants are associated with > 50% of the disease outbreaks. However, the mechanisms underlying the interaction of these human pathogens with plants remain elusive. In this study, we have explored plant resistance mechanisms against these enterobacteria and the plant pathogen Pseudomonas syringae pv. tomato (Pst) DC3118, as an opportunity to improve food safety. Results: We found that S. enterica serovar Typhimurium (STm) transcriptionally modulates stress responses in Arabidopsis leaves, including induction of two hallmark processes of plant defense: ROS burst and cell wall modifications. Analyses of plants with a mutation in the potentially STm-induced gene EXO70H4 revealed that its encoded protein is required for stomatal defense against STm and E. coli O157:H7, but not against Pst DC3118. In the apoplast however, EXO70H4 is required for defense against STm and Pst DC3118, but not against E. coli O157: H7. Moreover, EXO70H4 is required for callose deposition, but had no function in ROS burst, triggered by all three bacteria. The salicylic acid (SA) signaling and biosynthesis proteins NPR1 and ICS1, respectively, were involved in stomatal and apoplastic defense, as well as callose deposition, against human and plant pathogens. Conclusions: The results show that EXO70H4 is involved in stomatal and apoplastic defenses in Arabidopsis and suggest that EXO70H4-mediated defense play a distinct role in guard cells and leaf mesophyll cells in a bacteriadependent manner. Nonetheless, EXO70H4 contributes to callose deposition in response to both human and plant pathogens. NPR1 and ICS1, two proteins involved in the SA signaling pathway, are important to inhibit leaf internalization and apoplastic persistence of enterobacteria and proliferation of phytopathogens. These findings highlight the existence of unique and shared plant genetic components to fight off diverse bacterial pathogens providing specific targets for the prevention of foodborne diseases.

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Plant innate immunity against human bacterial pathogens

Cited by 52 publications

References 84 publications

Stomatal Defense a Decade Later

Stomatal Defense a Decade Later

Interaction between Salmonella and Plants: Potential Hosts and Vectors for Human Infection

Novel molecular components involved in callose-mediated Arabidopsis defense against Salmonella enterica and Escherichia coli O157:H7

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