Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry

Abstract

Adhesive hydrogels have gained popularity in biomedical applications, however, traditional adhesive hydrogels often exhibit short-term adhesiveness, poor mechanical properties and lack of antibacterial ability. Here, a plant-inspired adhesive hydrogel has been developed based on Ag-Lignin nanoparticles (NPs)triggered dynamic redox catechol chemistry. Ag-Lignin NPs construct the dynamic catechol redox system, which creates long-lasting reductive-oxidative environment inner hydrogel networks. This redox system, generating catechol groups continuously, endows the hydrogel with long-term and repeatable adhesiveness. Furthermore, Ag-Lignin NPs generate free radicals and trigger self-gelation of the hydrogel under ambient environment. This hydrogel presents high toughness for the existence of covalent and non-covalent interaction in the hydrogel networks. The hydrogel also possesses good cell affinity and high antibacterial activity due to the catechol groups and bactericidal ability of Ag-Lignin NPs. This study proposes a strategy to design tough and adhesive hydrogels based on dynamic plant catechol chemistry.

A Novel Double‐Crosslinking‐Double‐Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment

“…These explain the superior antibacterial performance of the present deign which combines the germ‐killing capability of the quinone group and the protonated amino group. On the other hand, unlike previous antibacterial hydrogels that were generally cell repellent, the hydrogel simultaneously exhibited good cytocompatibility due to catechol groups (cell affinity) on surface of the adhesive hydrogels 2b,26…”

Bioinspired Mineral–Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

“…The frequency sweep results showed that storage modulus ( G ′) was greater than loss modulus ( G ″) over the entire frequency range (Figure S7A, Supporting Information), which is indicative of elastic‐like behavior. The increasing trend in the G ′ value is characteristic for SF@TA@HA composed entirely of intermolecular non‐covalent interactions . The dynamic nature of these bonding structures contributed to properties associated with shear‐thinning and subsequent recovery, which are important parameters for designing materials for minimally invasive tissue engineering.…”

“…Phenolic compounds have a strong chelating ability with metal ions to form metal‐phenolic coordination bonds that endow metal‐phenolic materials with improved overall mechanical properties . In addition, phenolic compounds can also cross‐link with polymers such as proteins to assemble into hierarchical networks with appropriate water‐resistant adhesion performance, which mimics the adhesion mechanism of mussels . Thus, the collaborative self‐assembly mechanism of phenolic compounds offers the possibility to prepare a promising bone adhesive.…”

Ultra-fast self-gelling powder mediate robust wet adhesion to promote healing of gastrointestinal perforations

“…Adhesive hydrogels that can strongly adhere to wet tissues have been widely used in wound dressings, [1][2][3][4][5] hemostatic agents, [6][7][8][9][10] wearable devices, [11][12][13] drug delivery systems, 14,15 and tissue engineering, [16][17][18][19][20][21] owing to their strong adhesion, excellent biocompatibility, good permeability, high deformability, and tunable mechanical properties. Two main hydrogel design strategies have been adopted to achieve adhesion on wet tissues: adhering prefabricated adhesive hydrogels [22][23][24][25][26][27][28][29] on wet tissues and forming adhesive hydrogels on wet tissues in situ from precursor solutions.…”