Plant lipid transfer proteins' ligand enhances allergic sensitization to non‐related proteins in murine models

Abstract

To the Editor, Allergic sensitization is a complex process, characterized by the development of a heightened immune response to harmless substances, known as allergens. Identifying contributors to this response is crucial to understand its mechanisms and to develop effective prevention and treatment strategies. In this context, protein ligands have gained attention since the ligand carried by some plant pathogenesis-related proteins (PRs) are implicated in allergic sensitization. 1,2 Plant lipid transfer proteins (Plant-LTPs), main food allergens, transport a specific lipid ligand (LTPs' ligand) consisting of a polar head derived from camptothecin, linked through an amide bond to aThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.