Plant LysM proteins: modules mediating symbiosis and immunity

Gust, Andrea A.; Willmann, Roland; Desaki, Yoshitake; Grabherr, Heini M; Nürnberger, Thorsten

doi:10.1016/j.tplants.2012.04.003

Cited by 199 publications

(173 citation statements)

References 94 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…LysM-RPs and LysM-RKs represent a major class of receptors for microbial N-acetylglucosamine-containing glycans, including fungal chitin and bacterial peptidoglycan (PGN), which trigger defenses, and Rhizobium-and arbuscular mycorrhiza-derived lipochitooligosaccharides (LCOs), which trigger symbioses (Gust et al, 2012). Three Arabidopsis LysM-RLKs, CHITIN ELICITOR RECEPTOR KINASE1 (CERK1), LysM-CONTAINING RECEPTOR KINASE4 (LYK4), and LYK5, are required for chitin signaling (Miya et al, 2007;Wan et al, 2008Wan et al, , 2012Petutschnig et al, 2010;Cao et al, 2014), whereas CERK1 and two Arabidopsis LysM-RLPs, LysM DOMAIN-CONTAINING GPI-ANCHORED PROTEIN1 (LYM1) and LYM3, are required for response to PGN (Willmann et al, 2011).…”

Section: Rlks and Rpls Involved In Plant Immunitymentioning

confidence: 99%

Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition

2017

View full text Add to dashboard Cite

Section: Rlks and Rpls Involved In Plant Immunitymentioning

confidence: 99%

Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition

2017

View full text Add to dashboard Cite

“…PD1764 is annotated as a hypothetical protein that is present in other X. fastidiosa genomes. LysM (for lysin motif, Pfam PF01476) domains are well-known for their role in plant immune responses, in which they may serve as receptors for the recognition of common microbe-associated molecular patterns (MAMPs) (Gust et al 2012). Interestingly, MAMPs recognized by LysM are generally composed of GlcNAc-containing molecules, such as chitin on the surface of pathogenic fungi (Ohnuma et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Blocking the Transmission of a Noncirculative Vector-Borne Plant Pathogenic Bacterium

Labroussaa

Zeilinger

Almeida

2016

MPMI

View full text Add to dashboard Cite

The successful control of insect-borne plant pathogens is often difficult to achieve due to the ecologically complex interactions among pathogens, vectors, and host plants. Disease management often relies on pesticides and other approaches that have limited long-term sustainability. To add a new tool to control vector-borne diseases, we attempted to block the transmission of a bacterial insect-transmitted pathogen, the bacterium Xylella fastidiosa, by disrupting bacteria-insect vector interactions. X. fastidiosa is known to attach to and colonize the cuticular surface of the mouthparts of vectors; a set of recombinant peptides was generated and the chemical affinities of these peptides to chitin and related carbohydrates was assayed in vitro. Two candidates, the X. fastidiosa hypothetical protein PD1764 and an N-terminal region of the hemagglutinin-like protein B (HxfB) showed affinity for these substrates. These proteins were provided to vectors via an artificial diet system in which insects acquire X. fastidiosa, followed by an inoculation access period on plants under greenhouse conditions. Both PD1764 and HxfAD1-3 significantly blocked transmission. Furthermore, bacterial populations within insects over a 10-day period demonstrated that these peptides inhibited cell adhesion to vectors but not bacterial multiplication, indicating that the mode of action of these peptides is restricted to limiting cell adhesion to insects, likely via competition for adhesion sites. These results open a new venue in the search for sustainable disease-control strategies that are pathogen specific and may have limited nontarget effects.Vector-borne plant pathogens are among the most important threats to agriculture. Despite their economic importance, management of such diseases relies heavily on pesticide applications, primarily due to a poor understanding of their biology and how these pathogens are transmitted from plant to plant. Insect-borne pathogens have a complex lifestyle requiring the successive colonization of or interactions with two independent hosts, the plant and the vector. Numerous strategies developed to control these pathogens have independently targeted the insect or plant hosts, but the impact of these diseases continues to be significant. Alternatively, more selective approaches must be developed. A novel strategy that has been recently pursued, primarily with viral pathogens, is the disruption of vector-pathogen molecular interactions (Whitfield and Rotenberg 2015). Although the specific approaches that have been used to disrupt intricate vector-virus interactions vary, the general concept is based on providing insects with an excess of virus-encoded proteins or peptides required for interactions so that virions are outcompeted and cannot bind to putative receptors; in other words, insect receptors are masked so that virions are not retained (e.g., Guoying et al. 1999;Montero-Astúa et al. 2014). There is one example that used a proof-of-concept approach to demonstrate that transmission of a plant-pathogenic...

show abstract

“…In addition to pathogen defence, lysine motif-containing receptor kinases are involved in symbiotic plant-pathogen interactions, in which ROP GTPases also play a role [73]. The 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 expression of the Lotus japonicus ljrop6 gene is elevated after the inoculation of roots with…”

Section: The Lysin Motif Domain Receptor-like Kinasesmentioning

confidence: 99%

“…Mesorhizobium loti, the symbiotic bacterial partner of Lotus japonicus [73]. Moreover, the loss of ROP6 function due to RNA-interference inhibits the growth of the infection thread, resulting in fewer root nodules [73].…”

Section: The Lysin Motif Domain Receptor-like Kinasesmentioning

confidence: 99%

See 1 more Smart Citation

Signals fly when kinases meet Rho-of-plants (ROP) small G-proteins

Fehér

Lajkó

2015

Plant Science

View full text Add to dashboard Cite

Rho-type small GTP-binding plant proteins function as two-state molecular switches in cellular signalling. There is accumulating evidence that RHO-OF-PLANTS (ROP) signalling is positively controlled by plant receptor kinases, through the ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR proteins. These signalling modules regulate cell polarity, cell shape, hormone responses, and pathogen defence, among other things. Other ROP-regulatory proteins might also be subjected to protein phosphorylation by cellular HighlightsVarious types of receptor-like kinases positively regulate ROP signalling.The receptor kinase-RopGEF-ROP signalling module is used in a wide variety of cellular processes. 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 ROPs and their regulators are likely to be subjected to regulation by protein phosphorylation.ROPs might play a role in directly and indirectly activating downstream kinase signalling.

show abstract

Plant LysM proteins: modules mediating symbiosis and immunity

Cited by 199 publications

References 94 publications

Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition

Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition

Blocking the Transmission of a Noncirculative Vector-Borne Plant Pathogenic Bacterium

Signals fly when kinases meet Rho-of-plants (ROP) small G-proteins

Contact Info

Product

Resources

About