Plant-mediated green synthesis of metal-based nanoparticles for dermopharmaceutical and cosmetic applications

Paiva‐Santos, Ana Cláudia; Herdade, Ana Margarida; Guerra, Catarina; Peixoto, Diana; Pereira-Silva, Miguel; Zeinali, Mahdi; Mascarenhas-Melo, Filipa; Paranhos, António; Veiga, Francisco

doi:10.1016/j.ijpharm.2021.120311

Cited by 144 publications

(66 citation statements)

References 48 publications

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“…AuNPs Biosynthesised AuNPs are highly biocompatible and have less side effects [53] Reduction of inflammation, promotion of granulation tissue formation [46]. Antimicrobial activity [54].…”

Section: Nanoparticle Description Function/usementioning

confidence: 99%

“…Its introduction in clinics dates back to the early 1960s to treat burn wounds, but it was also marginally used to heal skin wounds in general. Its current formulation in the therapy of second-and third-degree burns is a 1% cream for topical administration [53]. The clinical application of silver sulfadiazine has been controversial since two Cochrane systematic studies (2010 and 2013) questioned its efficacy in burn wounds treatment and concluded that the evidence collected was not sufficient to establish it.…”

Section: Silver Sulfadiazine Nanomaterialsmentioning

confidence: 99%

“…Moreover, SSD exhibits delayed wound healing due to fibroblast toxicity. Nevertheless, silver sulfadiazine is still considered by many clinicians as a crucial topical drug in the management of burn patients [53]. To improve its efficacy and optimize its administration, nanotechnology has been exploited.…”

Section: Silver Sulfadiazine Nanomaterialsmentioning

confidence: 99%

“…In fact, bacteria can grow in two ways: the planktonic and the sessile forms. In the former, single bacterial cells are free to move, while in the latter they aggregate in colonies that can adhere to both living and non-living surfaces [53]. This may happen also in chronic wounds, and the occurrence of biofilms on damaged skin is always a concern, since such colonies are surrounded by a matrix of extracellular polymeric substances (mainly polysaccharides, but also small amounts of proteins, enzymes, DNA, and RNA) that shields the bacterial cells from the outer environment and prevents antibiotics from reaching them.…”

Section: Silver Sulfadiazine Nanomaterialsmentioning

confidence: 99%

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Nanomaterials in Skin Regeneration and Rejuvenation

Bellu

Medici

Coradduzza

et al. 2021

IJMS

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Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

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“…AuNPs Biosynthesised AuNPs are highly biocompatible and have less side effects [53] Reduction of inflammation, promotion of granulation tissue formation [46]. Antimicrobial activity [54].…”

Section: Nanoparticle Description Function/usementioning

confidence: 99%

Section: Silver Sulfadiazine Nanomaterialsmentioning

confidence: 99%

Section: Silver Sulfadiazine Nanomaterialsmentioning

confidence: 99%

Section: Silver Sulfadiazine Nanomaterialsmentioning

confidence: 99%

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Nanomaterials in Skin Regeneration and Rejuvenation

Bellu

Medici

Coradduzza

et al. 2021

IJMS

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“…Cancer is one of the serious human health problems globally, and its treatment is always associated with a variety of challenges 1 . Skin is the important and largest organ in the human body 2 which, undergoes the most exposure to the environment, including ultraviolet (UV) radiation from sunlight. Consequently, skin cancer is the most common cancer diagnosed in Caucasians in the United States and Australia 3 .…”

Section: Introductionmentioning

confidence: 99%

Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes

et al. 2021

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Cutaneous Wound‐Healing Activity of Quercetin‐Functionalized Bimetallic Nanoparticles

Yadav,

Neupane,

Otuechere

et al. 2024

Chemistry & Biodiversity

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Quercetin, a natural flavonol, is reported to have significant antioxidant and anti‐inflammatory activity, which further aids in its good wound healing properties via acting on acute as well as chronic inflammatory phases. The current study is focused on understanding the potential of the green synthesized iron and zinc oxide bimetallic (i.e., zinc ferrite) nanoparticles of quercetin (ZFQNP) on wound healing by in vivo study model. Bimetallic quercetin nanoparticles were prepared by co‐precipitation method and characterized by UV‐visible spectroscopy, scanning electron microscopy (SEM) and dynamic light scattering (DLS) analyses. Synthesized ZFQNP was utilized to prepare the ointment for topical application and wound healing activity was evaluated by using excisional wound method in Wistar rats. The binding affinity of quercetin was ascertained against various wound‐healing protein targets by molecular docking. Characterization data confirmed the synthesis of bimetallic ZFQNP of an irregular shape. Molecular docking studies showed satisfactory binding potential of quercetin with selected molecular targets. The study results of various parameters corroborated significant wound‐healing properties of ZFQNP, possibly attributed to the promising binding potential of quercetin with vital wound‐healing targets. The study demonstrated that the quercetin bimetallic nanoparticles could provide a promising wound‐healing effect.

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Plant-mediated green synthesis of metal-based nanoparticles for dermopharmaceutical and cosmetic applications

Cited by 144 publications

References 48 publications

Nanomaterials in Skin Regeneration and Rejuvenation

Nanomaterials in Skin Regeneration and Rejuvenation

Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes

Cutaneous Wound‐Healing Activity of Quercetin‐Functionalized Bimetallic Nanoparticles

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