Plant Metabolites as Immunomodulators

Jayaraman, Sony; Variyar, Jayadevi

doi:10.1007/978-981-15-5136-9_18

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…The immune system plays a vital role in well-being by increasing immune response and providing protection [ 124 ]. Polyphenols have well demonstrated immunomodulatory effects as they regulate the immune cells, macrophages, cytokines, signalling pathways and influence dendritic cells and lymphocytes (B and T), suppress T cell activation and natural killer cells, and suppress tumour-associated macrophages ( Figure 3 ) [ 125 , 126 , 127 , 128 , 129 , 130 ].…”

Section: Impacts Of Polyphenols On Human Healthmentioning

confidence: 99%

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Rathod

Abed

Punia³

et al. 2023

Plants

108

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Polyphenol has been used in treatment for some health disorders due to their diverse health promoting properties. These compounds can reduce the impacts of oxidation on the human body, prevent the organs and cell structure against deterioration and protect their functional integrity. The health promoting abilities are attributed to their high bioactivity imparting them high antioxidative, antihypertensive, immunomodulatory, antimicrobial, and antiviral activity, as well as anticancer properties. The application of polyphenols such as flavonoids, catechin, tannins, and phenolic acids in the food industry as bio-preservative substances for foods and beverages can exert a superb activity on the inhibition of oxidative stress via different types of mechanisms. In this review, the detailed classification of polyphenolic compunds and their important bioactivity with special focus on human health are addressed. Additionally, their ability to inhibit SARS-CoV-2 could be used as alternative therapy to treat COVID patients. Inclusions of polyphenolic compounds in various foods have demonstrated their ability to extend shelf life and they positive impacts on human health (antioxidative, antihypertensive, immunomodulatory, antimicrobial, anticancer). Additionally, their ability to inhibit the SARS-CoV-2 virus has been reported. Considering their natural occurrence and GRAS status they are highly recommended in food.

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Section: Impacts Of Polyphenols On Human Healthmentioning

confidence: 99%

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Rathod

Abed

Punia³

et al. 2023

Plants

108

View full text Add to dashboard Cite

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Phytocompounds and their molecular targets in immunomodulation: a review

Cherian

Velmurugan

Thiruganasambandham

et al. 2021

Journal of Basic and Clinical Physiology and Pharmacology

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Immune cells are important for the healthy function of every organ. The homeostasis of the immune system is selfregulated by T-cells, B-cells, and natural killer cells. The immunomodulation process of immune cells is part of the immunotherapy. According to therapeutic methods of immune responses are categorized as inducing (immunostimulant), amplification (immune booster), attenuation (immunomodulation), and prevention (immunosuppressive) actions. The prevalence of chronic immunological diseases like viral infections, allergies, and cancer is mainly due to the over-activation of the immune system. Further, immunomodulators are reported to manage the severity of chronic immunological disorders. Moreover, these immunomodulator-acting proteins are identified as potential molecular targets for the regulation of the immune system. Moreover, natural compound like phytocompounds are known to bind these targets and modulates the immune system. The specialized phytocompounds like curcumin, quercetin, stilbenes, flavonoids, and lignans are shown the immunomodulatory actions and ameliorate the immunological disorders. The present scenario of a COVID-19 pandemic situation has taught us the need to focus on strengthening the immune system and the development of the most promising immunotherapeutics. This review is focused on an overview of various phytocompounds and their molecular targets for the management of immunological disorders via immunosuppressants and immunostimulants actions.

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Plant Metabolites as Immunomodulators

Cited by 2 publications

References 48 publications

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Phytocompounds and their molecular targets in immunomodulation: a review

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