Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory

Shabuer, Gulimila; Ishida, Keishi; Pidot, Sacha J.; Roth, Martin; Dahse, Hans‐Martin; Hertweck, Christian

doi:10.1126/science.aac9990

Cited by 58 publications

(47 citation statements)

References 41 publications

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“…This hypothesis is supported by our [unpublished] observations, that nifH gene libraries prepared from the same plants as used in the current study are dominated by Clostridium -type genes in the (high) Arctic. Although Clostridium has been described as a strictly anaerobic genus, members of this genus have been shown to fix nitrogen in rice roots (Minamisawa et al, 2004), and survive in the potato endosphere in aerobic conditions (Shabuer et al, 2015). Interestingly, nifH genes of Clostridium spp.…”

Section: Discussionmentioning

confidence: 99%

Plants Assemble Species Specific Bacterial Communities from Common Core Taxa in Three Arcto-Alpine Climate Zones

et al. 2017

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Evidence for the pivotal role of plant-associated bacteria to plant health and productivity has accumulated rapidly in the last years. However, key questions related to what drives plant bacteriomes remain unanswered, among which is the impact of climate zones on plant-associated microbiota. This is particularly true for wild plants in arcto-alpine biomes. Here, we hypothesized that the bacterial communities associated with pioneer plants in these regions have major roles in plant health support, and this is reflected in the formation of climate and host plant specific endophytic communities. We thus compared the bacteriomes associated with the native perennial plants Oxyria digyna and Saxifraga oppositifolia in three arcto-alpine regions (alpine, low Arctic and high Arctic) with those in the corresponding bulk soils. As expected, the bulk soil bacterial communities in the three regions were significantly different. The relative abundances of Proteobacteria decreased progressively from the alpine to the high-arctic soils, whereas those of Actinobacteria increased. The candidate division AD3 and Acidobacteria abounded in the low Arctic soils. Furthermore, plant species and geographic region were the major determinants of the structures of the endophere communities. The plants in the alpine region had higher relative abundances of Proteobacteria, while plants from the low- and high-arctic regions were dominated by Firmicutes. A highly-conserved shared set of ubiquitous bacterial taxa (core bacteriome) was found to occur in the two plant species. Burkholderiales, Actinomycetales and Rhizobiales were the main taxa in this core, and they were also the main contributors to the differences in the endosphere bacterial community structures across compartments as well as regions. We postulate that the composition of this core is driven by selection by the two plants.

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Section: Discussionmentioning

confidence: 99%

Plants Assemble Species Specific Bacterial Communities from Common Core Taxa in Three Arcto-Alpine Climate Zones

et al. 2017

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“…This shows that also non‐actinomycetal bacteria can be promising sources for novel antimicrobials. This is also exemplified by the production of several new antibiotics by anaerobiers, such as Clostridium beijerinckii , which recently has been shown to produce the pentacyclic polyphenol clostrubin, which is a highly active substance against diverse pathogenic bacteria (Letzel et al ., 2013; Pidot et al ., 2014; Shabuer et al ., 2015). …”

Section: Novel Approaches For Drug Discoverymentioning

confidence: 99%

Antibiotic drug discovery

Wohlleben

Mast

Stegmann

et al. 2016

Microbial Biotechnology

143

113

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SummaryDue to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the consequence of several new and revolutionizing drug discovery and development techniques, which is initiating a ‘New Age of Antibiotic Discovery’. In this review, we concentrate on the most significant discovery approaches during the last and present years and comment on the challenges facing the community in the coming years.

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“…This shows that also non-actinomycetal bacteria can be promising sources for novel antimicrobials. This is also exemplified by the production of several new antibiotics by anaerobiers, such as Clostridium beijerinckii, which recently has been shown to produce the pentacyclic polyphenol clostrubin, which is a highly active substance against diverse pathogenic bacteria ( Letzel et al, 2013;Pidot et al, 2014;Shabuer et al, 2015).…”

Section: Novel Approaches For Drug Discoverymentioning

confidence: 99%

Antibiotic Drug Discovery

Firestine¹,

Lister²

2017

Drug Discovery

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SummaryDue to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the consequence of several new and revolutionizing drug discovery and development techniques, which is initiating a 'New Age of Antibiotic Discovery'. In this review, we concentrate on the most significant discovery approaches during the last and present years and comment on the challenges facing the community in the coming years.

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Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory

Cited by 58 publications

References 41 publications

Plants Assemble Species Specific Bacterial Communities from Common Core Taxa in Three Arcto-Alpine Climate Zones

Plants Assemble Species Specific Bacterial Communities from Common Core Taxa in Three Arcto-Alpine Climate Zones

Antibiotic drug discovery

Antibiotic Drug Discovery

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