Plant polyphenols can directly affect ovarian cell functions and modify toluene effects

Sirotkin, Alexander V.; Záhoranska, Zuzana; Tarko, Adam; Fabová, Zuzana; Alwasel, Saleh; Harrath, Abdel Halim

doi:10.1111/jpn.13461

Cited by 20 publications

(28 citation statements)

References 26 publications

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“…The comparison of the effects of elderberry extract and rutin showed the similar effects for the extracts and its major component. In experiments of Sirotkin et al [8,89], the addition of rutin was found to increase the viability of cultured porcine ovarian granulosa cells, although this effect was not associated with changes in the accumulation of markers of proliferation (accumulation of PCNA) and cytoplasmic apoptosis (Bax). In vivo experiments, like in vitro ones, demonstrated the stimulatory action of rutin on rat ovarian cell health and ovarian folliculogenesis [90,91].…”

Section: Effect Of Elderberry and Its Constituents On Ovarian Cell Vi...mentioning

confidence: 88%

“…Oxidative stress can be prevented by antioxidants [4]. The most natural, accessible and inexpensive sources of antioxidants, which can affect reproductive processes and prevent numerous reproductive disorders, are plants [6,8]. Additionally, because of implications on health, there is a growing interest in the use of plant-based antioxidants in the food industry.…”

Section: Introductionmentioning

confidence: 99%

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Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction

et al. 2022

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The present review summarizes the current knowledge concerning provenance, properties, physiological and therapeutic actions of elderberry and the bioactive molecules present in the plant, with emphasis on their action on female reproduction. Elderberry or black elder (Sambucus nigra L.) attracts attention due to its easy cultivation and high availability of bioactive compounds. Most of the available data concerning black elder’s therapeutic action are focused on its effects such as activation of immune processes and anti-inflammatory processes (cytokine production, etc.) and regulation of hormones and their receptors in cancer cells. The effects of elderberry on reproduction have been poorly investigated so far. Nevertheless, conducted studies so far demonstrate the stimulatory influence of black elder extract and its constituents, such as rutin, anthocyanins and agglutinins, on the viability and steroidogenesis of healthy ovarian cells as well as their ability to promote apoptosis and reduce the viability and proliferation of ovarian cancer cells. Furthermore, the action of black elder extract and its constituent biomolecules, such as anthocyanins and lectins, on embryogenesis and the embryonal estradiol-estradiol receptor system have also been reported. The available information, despite limitations, suggest the applicability of black elder constituents for improvement of reproductive processes in animal biotechnology, animal production and assisted reproduction, as well as for prevention and treatment of reproductive disorders (including cancer) in veterinary and human medicine.

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Section: Effect Of Elderberry and Its Constituents On Ovarian Cell Vi...mentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction

et al. 2022

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“…However, studies reporting its effects on ovarian function are still limited. In our previous in vitro studies, we demonstrated that toluene inhibited ovarian cell viability, proliferation and estrogen release [ 38 , 44 ]. In this study, we investigated the in vivo effect of toluene using female Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

Toluene Can Disrupt Rat Ovarian Follicullogenesis and Steroidogenesis and Induce Both Autophagy and Apoptosis

Alrezaki

Aldawood

Mansour

et al. 2021

Biology

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Toluene has been shown to be highly toxic to humans and animals and can cause damage to various tissues. However, studies reporting its effects on ovarian function are still limited. In this study, we investigated the in vivo effect of toluene using female Wistar rats. We found that toluene exposure decreased ovarian weight and affected ovarian structure by increasing the number of abnormally growing follicles. Moreover, it significantly increased progesterone and testosterone levels. We also showed that toluene exposure decreased GDF-9 protein and its encoding gene. In addition, it inhibited the expression of most of the genes involved in granulosa cell proliferation and differentiation, such as Insl3, ccnd2 and actb. The TUNEL assay showed that apoptosis occurred at the middle and high doses only (4000 and 8000 ppm, respectively), whereas no effect was observed at the low dose (2000 ppm). Interestingly, we showed that toluene exposure induced autophagy as LC3 protein and its encoding gene significantly increased for all doses of treatment. These results may suggest that the activation of autophagy at a low dose of exposure was to protect ovarian cells against death by inhibiting apoptosis, whereas its activation at high doses of exposure triggered apoptosis leading to cell death.

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“…Other phytoestrogens, such as quercetin (QUE) [62][63][64][65][66][67][68], apigenin (APE) [69][70][71][72][73][74], resveratrol (RES) [75][76][77][78][79], myricetin (MYR) [80][81][82][83][84][85], and are found in many berries, leafy greens, and wine. Although their relative binding affinity differences between ERα and ERβ are not as great as in GEN and DAI, these compounds have been investigated due to their widespread presence in plants and extensive human consumption.…”

Section: Phytoestrogens: Plant-derived Chemicalsmentioning

confidence: 99%

“…Although their relative binding affinity differences between ERα and ERβ are not as great as in GEN and DAI, these compounds have been investigated due to their widespread presence in plants and extensive human consumption. More specifically, QUE, APE, and even RES have been noted to exhibit a biphasic effect; at low concentrations, these phytoestrogens display estrogenic activity, whereas, at higher concentrations, they display more protective anti-estrogenic activity [62][63][64][65][66][67][68][69][70][71][72][73]. Like GEN, RES has been extensively studied in many clinical trials.…”

Section: Phytoestrogens: Plant-derived Chemicalsmentioning

confidence: 99%

Exploring the Biological Activity and Mechanism of Xenoestrogens and Phytoestrogens in Cancers: Emerging Methods and Concepts

Wang

Yoshitake

et al. 2021

IJMS

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Xenoestrogens and phytoestrogens are referred to as “foreign estrogens” that are produced outside of the human body and have been shown to exert estrogen-like activity. Xenoestrogens are synthetic industrial chemicals, whereas phytoestrogens are chemicals present in the plant. Considering that these environmental estrogen mimics potentially promote hormone-related cancers, an understanding of how they interact with estrogenic pathways in human cells is crucial to resolve their possible impacts in cancer. Here, we conducted an extensive literature evaluation on the origins of these chemicals, emerging research techniques, updated molecular mechanisms, and ongoing clinical studies of estrogen mimics in human cancers. In this review, we describe new applications of patient-derived xenograft (PDX) models and single-cell RNA sequencing (scRNA-seq) techniques in shaping the current knowledge. At the molecular and cellular levels, we provide comprehensive and up-to-date insights into the mechanism of xenoestrogens and phytoestrogens in modulating the hallmarks of cancer. At the systemic level, we bring the emerging concept of window of susceptibility (WOS) into focus. WOS is the critical timing during the female lifespan that includes the prenatal, pubertal, pregnancy, and menopausal transition periods, during which the mammary glands are more sensitive to environmental exposures. Lastly, we reviewed 18 clinical trials on the application of phytoestrogens in the prevention or treatment of different cancers, conducted from 2002 to the present, and provide evidence-based perspectives on the clinical applications of phytoestrogens in cancers. Further research with carefully thought-through concepts and advanced methods on environmental estrogens will help to improve understanding for the identification of environmental influences, as well as provide novel mechanisms to guide the development of prevention and therapeutic approaches for human cancers.

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Plant polyphenols can directly affect ovarian cell functions and modify toluene effects

Cited by 20 publications

References 26 publications

Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction

Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction

Toluene Can Disrupt Rat Ovarian Follicullogenesis and Steroidogenesis and Induce Both Autophagy and Apoptosis

Exploring the Biological Activity and Mechanism of Xenoestrogens and Phytoestrogens in Cancers: Emerging Methods and Concepts

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